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The San Francisco 49ers head to Louisiana this week to face the New Orleans Saints in a matchup featuring two teams that had very different endings to their season openers. For more game previews and betting breakdowns, check the NFL picks page. San Francisco earned a 17-13 comeback win over Seattle in Week 1 but lost quarterback Brock Purdy to shoulder and toe injuries. With Purdy listed as doubtful, Mac Jones is expected to start. Jones has 49 career NFL starts, with previous stints in New England and Jacksonville. Without George Kittle, who is on injured reserve with a hamstring injury, the 49ers will lean even more on Christian McCaffrey. The All-Pro back had 141 scrimmage yards in Week 1

The New York Giants head to Texas to face the Dallas Cowboys in a divisional matchup that could quickly define their 2025 season. Both teams lost in Week 1 and now risk falling into a dangerous 0-2 hole in the NFC East standings. For full coverage and betting analysis, visit the NFL picks hub. Dallas dropped its opener to the Eagles 24-20 but now returns home. Dak Prescott has dominated the Giants in his career, winning 13 straight starts against New York. Coach Brian Schottenheimer emphasized home-field advantage and explosive plays as key areas of focus, particularly with Micah Parsons no longer in the fold after his trade to Green Bay. The Giants are already fighting quarterback controversy. Russell Wilson

The Buffalo Bills and New York Jets collide Sunday in an AFC East matchup that already carries weight after both teams experienced nail-biting Week 1 finishes. The Bills escaped with a 41-40 win over Baltimore, while the Jets suffered a heartbreaking 34-32 loss to Pittsburgh. With only one AFC East team posting a win in the opening week, Buffalo enters atop the division. For more insights and betting breakdowns, check the NFL picks page. Bills coach Sean McDermott didn’t sugarcoat things. He pushed his team into full pads Wednesday, insisting that good enough is not enough. Buffalo surrendered 238 rushing yards to the Ravens, including three rushing touchdowns, and knows the Jets will attempt to pound the ball with Justin

The Cleveland Browns and Baltimore Ravens both enter Week 2 at 0-1, but the biggest headline is Joe Flacco’s return to Baltimore. The 40-year-old quarterback, who spent 11 seasons with the Ravens and won Super Bowl MVP in 2013, will step back into M&T Bank Stadium for the first time as a visitor. Flacco remains the Ravens’ all-time leader in passing yards (38,245) and touchdowns (212). Baltimore coach John Harbaugh reflected on that era fondly, calling it “iconic in Baltimore football history.” Lamar Jackson also reminisced about their time together, remembering Flacco’s humor and leadership. The Ravens dropped their opener in stunning fashion, losing 41-40 to the Buffalo Bills after allowing 16 unanswered points in the final 3:56. Lamar Jackson