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Boston Red Sox vs New York Yankees Picks and Predictions April 22nd 2026
The Yankees and Red Sox are back at Fenway Park on Wednesday night, with first pitch set for 6:45 p.m. ET. New York comes in at 14-9, leading the AL East and riding a four-game winning streak, while Boston is 9-14, last in the division and five games back after dropping Tuesday’s opener. This is Game 2 of a three-game series, and it already feels important for Boston because the Red Sox are trying to keep this from turning into another stretch where the offense puts them in a hole early. Tuesday’s 4-0 Yankees win fit the broader trend. New York has won five of its last six, and Boston has now scored three runs or fewer in 12 of
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New York Mets vs Minnesota Twins Picks and Predictions April 22nd 2026
Minnesota heads to Citi Field on Wednesday night for the middle game of this series, with first pitch set for 7:10 p.m. ET on SNY. The Twins are 12-11 and second in the AL Central after Tuesday’s 5-3 comeback win, while the Mets have fallen to 7-16, fifth in the NL East, and are now carrying a 12-game losing streak into this matchup. That contrast is the whole handicap right now. One team has been uneven but competitive. The other keeps finding new ways to lose. The starter situation changed during the day. Minnesota is no longer listed with a TBD arm and will go with Connor Prielipp, while New York sticks with Clay Holmes. That matters because Holmes has
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Chicago Cubs vs Philadelphia Phillies Picks and Predictions April 22nd 2026
The Phillies head into Wrigley Field trying to stop a free fall. Philadelphia is 8-15, fourth in the NL East, just 2-8 over its last 10, and riding a seven-game losing streak. Chicago is moving the other direction at 14-9, second in the NL Central, 8-2 over its last 10, and on a seven-game winning streak. First pitch is set for 7:40 p.m. ET, with coverage listed on Marquee Sports Network and NBCSP+, and the weather around game time looks cool in the low 50s with light wind. That recent form matters here because the Cubs are not just squeaking by. They have a +37 run differential and have already taken the first two games of this series, winning 5-1
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Texas Rangers vs Pittsburgh Pirates Picks and Predictions April 22nd 2026
The Pirates and Rangers meet Wednesday night at Globe Life Field in Arlington, with first pitch set for 8:05 p.m. ET. Pittsburgh comes in at 13-10, fifth in the NL Central, while Texas is 12-11 and second in the AL West after opening the series with a 5-1 win on Tuesday. This is a pretty interesting early-season matchup because the records are close, the market is basically flat, and both teams have leaned on pitching more than explosive offense so far. Tuesday’s opener also gave this game a different feel. Texas held Pittsburgh to one run, got six solid innings from Kumar Rocker, and extended its home winning streak to four games, while the Pirates dropped to 5-5 on the
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Colorado Rockies vs San Diego Padres Picks and Predictions April 22nd 2026
The Padres and Rockies are back at Coors Field on Wednesday night, with first pitch set for 8:40 p.m. ET in Denver. San Diego comes in at 16-7 and second in the NL West, while Colorado is 9-15 and fifth after dropping Tuesday’s opener 1-0. The Padres have won three straight, and this is starting to feel like another spot where the better roster is trying to squeeze a divisional opponent before the market fully catches up. San Diego has been much steadier than Colorado in the early season sample, especially away from home. The Padres are 7-3 on the road, and even with an offense that has not fully clicked yet, they keep winning because the run prevention has

Cincinnati Reds vs San Diego Padres Picks and Predictions May 23rd 2024

Cincinnati Reds vs San Diego Padres Picks and Predictions May 23rd 2024

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Luis Arraez Ignites Padres as They Aim for Series Win vs. Reds The San Diego Padres, fueled by a standout performance from … more

Ny Yankees Yankees vs Seattle Mariners Picks and Predictions

Ny Yankees Yankees vs Seattle Mariners Picks and Predictions May 23rd 2024

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Yanks Rookie Luis Gil Eyes Another Impressive Outing vs. M’s New York Yankees rookie pitcher Luis Gil has been turning heads with … more

Boston Celtics vs Indiana Pacers Picks

Boston Celtics vs Indiana Pacers Picks and Predictions May 23rd 2024

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Pacers Determined to Clean Up Play Against Celtics in Game 2 The Indiana Pacers are gearing up for a crucial Game 2 … more

Dallas Stars vs Edmonton Oilers Picks and Predictions May 23rd 2024

Dallas Stars vs Edmonton Oilers Picks and Predictions May 23rd 2024

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Stars vs. Oilers: Epic Showdown in Western Conference Final The stage is set for an electrifying Western Conference finals as the Dallas … more

Philadelphia Phillies vs Texas Rangers Picks and Predictions

Philadelphia Phillies vs Texas Rangers Picks and Predictions May 23rd 2024

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Phillies Poised for Second Straight Series Sweep Against Rangers The Philadelphia Phillies are riding high with their best 50-game start in franchise … more