New York Mets vs Minnesota Twins Picks and Predictions April 22nd 2026

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Minnesota heads to Citi Field on Wednesday night for the middle game of this series, with first pitch set for 7:10 p.m. ET on SNY. The Twins are 12-11 and second in the AL Central after Tuesday’s 5-3 comeback win, while the Mets have fallen to 7-16, fifth in the NL East, and are now carrying a 12-game losing streak into this matchup. That contrast is the whole handicap right now. One team has been uneven but competitive. The other keeps finding new ways to lose.

The starter situation changed during the day. Minnesota is no longer listed with a TBD arm and will go with Connor Prielipp, while New York sticks with Clay Holmes. That matters because Holmes has been one of the few Mets bright spots, but it also means the market is asking bettors to lay a real price with a team that is 0-10 in its last 10 and has been collapsing late almost every night.

Weather should not be a huge factor. Forecast conditions around first pitch are cool, in the low-to-mid 50s, with clouds and earlier rain clearing out before game time. So this looks more like a standard Citi Field environment than a weather-driven total spot. One other note: Juan Soto is expected to be activated before first pitch, which gives the Mets a needed boost, but it does not suddenly erase the larger form problem.

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Minnesota Twins vs New York Mets Odds

These are the current betting lines, and bettors should always monitor the latest MLB odds before placing a wager because this game is still dealing with pricing around a newly confirmed Twins starter.

TeamMoneylineRun LineTotal
Minnesota Twins+135+1.5 (-163)O 8 (-112)
New York Mets-163-1.5 (+135)U 8 (-108)

Minnesota Twins Betting Form

Minnesota is not an elite offense, but it is clearly the healthier one in this matchup from a production standpoint. The Twins enter with a .228 average, .329 OBP, .378 slugging percentage, and 27 home runs, all better than what the Mets have put up so far. Byron Buxton gives them real extra-base juice, Josh Bell leads the club with 15 RBI, and Tuesday’s rally showed that they can still generate late pressure even when the game starts slowly. For a broader look at the slate, the today’s MLB picks board is useful, but the key point here is simple: Minnesota is getting more from its lineup than New York right now.

Prielipp is the variable. He has no MLB stat line yet, so there is more uncertainty than usual when you handicap the first five innings. That said, the market seems to be treating the Twins like a team with no pitching answer at all, and that feels too aggressive given how shaky the Mets offense has been. If Minnesota gets even a competent debut outing, the rest of the roster profile is good enough to keep this game live deep into the night.

The betting translation is pretty clear. Minnesota makes the most sense as a plus-money side because the price is being driven more by Holmes than by the actual state of the Mets. When one team has the better recent result, the better record, and the better offensive baseline, I am interested if the market is still giving me +135.

New York Mets Betting Form

New York’s case starts and almost ends with Holmes. He is 2-2 with a 1.96 ERA, 1.09 WHIP, 23 innings pitched, and only two home runs allowed. Those are good numbers, and they are the main reason the Mets are still favored despite everything else going wrong around them. You can compare this game with the rest of the card on the MLB preview board, but Holmes is the one element of this matchup that still looks trustworthy on the Mets side.

The problem is the offense and the game state behind him. The Mets are batting .222 with a .285 OBP and .332 slugging percentage, and they have scored just 75 runs while allowing 102. They have now lost 12 straight, and Tuesday’s game was another example of how fragile the full-game profile has become, with a late bullpen collapse turning a winnable spot into another loss. Even with Soto expected back, asking this lineup to justify a price in the -160 range feels expensive.

There is still enough talent here to win, obviously. Francisco Lindor and Francisco Alvarez can change a game with one swing, and Soto’s return could stabilize the lineup quickly. But from a betting perspective, I need more than theoretical upside if I am laying this kind of number. The Mets are not just cold. They are playing like a team that does not trust its own late innings right now.

Minnesota Twins vs New York Mets Matchup Breakdown

This matchup is basically Holmes versus the rest of the board. If you isolate the starting pitchers, the Mets have the cleaner known commodity. If you widen the lens to full-team performance, Minnesota has the edge. The Twins have been the better offense, they come in off a win in this same series, and the Mets have not shown they can protect leads or string together enough quality at-bats to consistently cash favorite tickets. That is why this becomes more of a price argument than a pure talent argument. The MLB betting guide matters in spots like this because it reminds you that a strong starter does not automatically justify a favorite if the full-game environment is working against him.

I also think the total is a little tricky. Citi Field weather looks cool, Holmes has been effective, and Minnesota is sending out a lefty with no big-league track record yet, which can create some uncertainty early. But the Mets bullpen has been unstable, and the Twins have gone over often lately. I can see both sides of that number, which usually means the side is the cleaner angle.

The biggest edge for Minnesota is probably psychological and structural, not just statistical. The Twins do not need to be perfect here. They just need to stay close and let the game get to the later innings, where New York has been unraveling. That is not always the most comfortable handicap, but it matters when the dog price is this playable.

Minnesota Twins vs New York Mets Predictions and Best Bets

I lean to Minnesota on the moneyline. Holmes is good enough that I understand why the Mets opened favored, but the current number is still asking too much from a team on a 12-game losing streak with one of the weaker offensive profiles in the league. If this were closer to a pick’em, maybe I would leave it alone. At +135, I think the value is on the Twins.

I do not love forcing a total play here. Under 8 makes some sense if Holmes controls the game and Prielipp settles in, but the Mets bullpen has become too volatile for me to feel great about needing a clean final third of the game. Over 8 has a path too, especially if New York presses and the late innings get messy again. So I would rather avoid the total than pretend there is a huge edge there.

From a derivative standpoint, Minnesota first five is tougher because of the unknown attached to Prielipp. Full game is better because it lets you bet against the Mets’ full team profile, not just Holmes. That is the difference for me. You are buying the better price against the more unstable club.

Best Bet: Twins Moneyline +135.

MLB Picks and Handicappers on ScoresAndStats

If you are building out a full baseball card instead of betting one game in isolation, it helps to compare different styles and recent form before locking into a pick. The handicapper leaderboard gives you that transparency, which matters in MLB because daily volume can make short-term variance look bigger than it really is.

For bettors who want a wider slate approach, premium MLB picks are the cleaner way to add more board coverage without forcing low-confidence plays. Baseball is a grind, and the best approach is usually to focus on price, consistency, and long-term results rather than chasing one hot narrative.

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