Pittsburgh Panthers vs Louisville Cardinals Picks and Predictions January 17th 2026

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The Pittsburgh Panthers look to build on their recent win, while the Louisville Cardinals aim to bounce back in this ACC clash at Petersen Events Center.

Line Movement and Odds

Louisville enters as the favorite, but Pittsburgh’s home record makes this line competitive. Current market:

  • Pittsburgh Spread: +7.5 (-113)
  • Louisville Spread: -7.5 (-110)
  • Pittsburgh MoneyLine: +251
  • Louisville MoneyLine: -327
  • Total: 152.5 (-110)

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Matchup Breakdown

Pittsburgh Outlook

The Panthers average 74.1 points per game, with Brandin Cummings, Nojus Indrusaitis, and Cameron Corhen leading the offense. Cummings’ 23 points vs Georgia Tech highlighted his scoring punch, while Indrusaitis’ 16 points and four treys showcased his perimeter shooting. Pittsburgh’s shooting efficiency (45.8% FG) and home record (7-5) underscore their strengths. Their 8-9 record shows inconsistency, but their ability to compete at Petersen Events Center makes them dangerous.

Louisville Outlook

The Cardinals average 87.2 points per game, with Ryan Conwell, Isaac McKneely, and Mikel Brown Jr. (when healthy) driving production. Conwell’s 19.5 points per game lead the team, while McKneely’s 23 points vs Virginia showcased his impact. Louisville’s shooting efficiency (11.7 threes per game, 11th nationally) and rebounding (41.6 per game) underscore their strengths. Their 12-5 record and 10-3 mark as favorites highlight consistency, making them tough even on the road.

Key Factors

This matchup may hinge on perimeter defense and rebounding. Pittsburgh thrives on bench scoring and balanced offense, while Louisville must rely on Conwell’s scoring and three-point shooting to tilt the game. Turnovers and late-game execution will likely decide the margin.

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Injuries / Availability

Pittsburgh: No injuries reported.

Louisville: Mikel Brown Jr. (back) remains questionable; Khani Rooths (illness) could return.

Environment

Petersen Events Center has been a reliable venue for Pittsburgh, where they’ve gone 7-5 this season. Louisville enters with confidence despite recent losses, making this a clash of home strength vs national-ranked resilience.

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Best Bets and Prediction

Projected Final Score: Louisville 85, Pittsburgh 75

  • Louisville -7.5 → Best Bet. Their offensive efficiency and balanced scoring suggest they can cover the spread.
  • Under 152.5 → Total play. Both teams’ slower pace points toward a combined score below the line.

Louisville’s depth and offensive rhythm should carry them to victory, while Pittsburgh’s home-court advantage keeps the game competitive. Expect a moderately high-scoring contest with totals landing just under the posted number.

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