2021 NFL Thanksgiving Day Odds and Predictions

The 2021 Thanksgiving Day NFL slate is upon us. The traditional opening game in Detroit will be followed by a date in Dallas. The nightcap features two teams looking to secure their spot in their respective division races.

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Bettors looking to capitalize on Week 12 in the NFL can get off to an early start. Her are the 2021 NFL Thanksgiving Day odds and predictions.

Chicago Bears vs. Detroit Lions

Bears vs. Lions Picks

Best Bet: OVER 41.5

So, these are two of the worst offenses in the NFL. The Bears rank 29th in scoring followed by the Lions at No. 30. Neither team scores over 20 points per game and, in fact, the Lions haven’t scored over 20 points in a game since their season opener.

Lions QB Jared Goff is questionable and if he doesn’t play it will be up to backup Tim Boyle to run the show. Bears rookie QB Justin Fields struggles.

Here’s the thing though. The Lions defense is awful (30th in scoring). The Bears defense is mediocre but will probably be worse now that Khalil Mack is out for the season.

In three of the last four Bears-Lions games, the two teams combined for 48 or more points. Both teams will pull out all the stops on Thanksgiving Day. With a total this low, it’s going Over on Turkey Day.

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Las Vegas Raiders vs. Dallas Cowboys

Raiders vs. Cowboys Picks

Best Bet: OVER 50.5

The Cowboys are a seven-point favorite over the Raiders at home on Thanksgiving. With the quick turnaround, laying a touchdown just seems to iffy to back the Cowboys to cover.

Both teams’ offenses are very good. The Raiders have the third-ranked passing offense in the league. Dallas is No. 5 in both rushing and passing offense and sixth in scoring. The Cowboys were held to nine points by the Chiefs last week. They are going to erupt on Thursday against a Raiders defense that is 25th in scoring defense.

The Raiders will put up enough points to push this game total Over the posted total of 50.5.

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Buffalo Bills vs. New Orleans Saints

Bills vs. Saints Picks

Best Bet: BILLS -4.5

The Bills have lost two of their last three games. The Saints are 0-for-3 in their last three games. Trevor Siemian at quarterback has limited the offense and the possibility of not having RB Alvin Kamara on Thursday makes it even worse for the Saints. Kamara is listed as questionable with a knee injury.

Buffalo turned the ball over four times against Indy last week. This is still a Super Bowl-caliber football team. The defense is solid and Josh Allen and the offense have shown they can score on just about anyone.

The Bills are 13-6-1 ATS in their last 20 games. The Saints are 1-2 ATS in their last three and 3-6 ATS in the last nine seasons in Week 12.

This is a spot where Buffalo knows it needs a win. They will rise to the occasion and get the cover.