NCAA Football Week 5 Point Spread Picks

The 2022 college football season is really starting to heat up now that we are heading into week 5. Conference action has started to take over throughout the country and that means there are bigger games on the schedule.

NCAA Football Betting Sites

With so many different games to look at, you will also find several good ways to bet on the action. Here are five of the best CFB week 5 point spread picks to make. Learn what a point spread bet is in our betting guide.

Illinois Fighting Illini at Wisconsin Badgers

Illinois vs. Wisconsin Picks

Best Bet: Illinois +8.5

The Illinois Fighting Illini are one play away from being a perfect 4-0 on the year. Illinois is giving up just eight points per game and they have a rushing attack that can put up points in a hurry.

Wisconsin was just blown out by Ohio State in week 4 and the Badgers are a team that is struggling to get stops. The Badgers should be able to win this game, but it’s not going to be easy.

Take the 8.5 points and back the Fighting Illini in this one.

NCAA Football ATS Odds

Oklahoma Sooners at TCU Horned Frogs

Oklahoma vs. TCU Picks

Best Bet: Oklahoma -5

Oklahoma might have seen their chances at reaching the CFP end in week 4, as they were stunned by Kansas State. The Sooners will now be looking to bounce back against a TCU team that is a perfect 3-0.

The Horned Frogs are scoring over 46 points per game this season, but they haven’t been facing a very difficult schedule. TCU is not a good defensive team and that’s going to be a problem against the Sooners.

Look for Oklahoma to make a statement in this game as they win and cover the spread.

Texas Tech Red Raiders at Kansas State Wildcats

Texas Tech vs. Kansas State Picks

Best Bet: Texas Tech +7.5

A pair of 3-1 teams meet up, as Kansas State hosts Texas Tech. Both of these programs picked up a huge upset win in week 4 and it’s going to set up a showdown in this one.

Neither team feels like they are one of the best teams in the country, but they have been playing well to begin the year. This game should feature plenty of scoring and it’s one that will likely go back and forth.

The best bet to make in this game is taking the 7.5 points, as the Red Raiders will keep it close on the road.

NCAA Football ATS Predictions

Oklahoma State Cowboys at Baylor Bears

Oklahoma State vs. Baylor Picks

Best Bet: Baylor -2.5

Two of the best offensive teams in the country meet on Saturday as Baylor hosts Oklahoma State. The Cowboys have not been challenged at all this season, but they have also been facing a pretty weak schedule.

Baylor just went on the road and beat a pretty good Iowa State team and that will give them some momentum for this game. Oklahoma State just hasn’t faced a real defense yet and the Cowboys will struggle to keep this one close.

NC State Wolfpack at Clemson Tigers

NC State vs. Clemson Picks

Best Bet: Clemson -6.5

A pair of 4-0 teams meet up for a huge showdown in the ACC when the Clemson Tigers host the NC State Wolfpack. Even though there is still a long season ahead, this game could show who the best team in the conference is.

The Wolfpack have been a great defensive team this season, but trying to stop Clemson is no easy task. The Tigers just survived a huge challenge at Wake Forest and that offense is lighting up the scoreboard.

Take the Tigers -6.5 as they pick up a comfortable win on Saturday.