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NFL Week 2 Picks – Expert Handicappers on Spreads, Totals, and Money Lines
What are the expert predictions for Week 2 in the NFL from Scores and Stats? Which underdog is set to surprise this week? Check out the latest schedules for your favorite teams and log in now to uncover the expert picks that could make all the difference!
Are you prepared to make smart NFL picks? Which three teams should you focus on this week for a guaranteed win? Dive into our up-to-date NFL picks and head to our members’ area to see which teams are primed to cover the spread, supported by insights from our experienced handicappers!
2025 NFL Week 2 Schedule
The 2025 NFL season continues with an exciting Week 2 lineup, filled with intense divisional matchups, high-stakes games, and thrilling opportunities for upsets.
From the NFL Thursday night showdown to Monday Night Football action, fans and bettors are in for another jam-packed weekend. Check out the full Week 2 schedule below, complete with game dates, times, and locations to help you plan your football weekend.
| Date | Matchup | Time | Location |
|---|---|---|---|
| Sunday, Sept 14, 2025 | Washington @ Green Bay | 6:15 PM | Lambeau Field, Green Bay, WI |
| Sunday, Sept 14, 2025 | Jacksonville @ Cincinnati | 11:00 AM | Paycor Stadium, Cincinnati, OH |
| Sunday, Sept 14, 2025 | New York @ Dallas | 11:00 AM | AT&T Stadium, Arlington, TX |
| Sunday, Sept 14, 2025 | Chicago @ Detroit | 11:00 AM | Ford Field, Detroit, MI |
| Sunday, Sept 14, 2025 | Los Angeles @ Tennessee | 11:00 AM | Nissan Stadium, Nashville, TN |
| Sunday, Sept 14, 2025 | New England @ Miami | 11:00 AM | Hard Rock Stadium, Miami Gardens, FL |
| Sunday, Sept 14, 2025 | San Francisco @ New Orleans | 11:00 AM | Caesars Superdome, New Orleans, LA |
| Sunday, Sept 14, 2025 | Buffalo @ New York | 11:00 AM | MetLife Stadium, East Rutherford, NJ |
| Sunday, Sept 14, 2025 | Seattle @ Pittsburgh | 11:00 AM | Acrisure Stadium, Pittsburgh, PA |
| Sunday, Sept 14, 2025 | Cleveland @ Baltimore | 11:00 AM | M&T Bank Stadium, Baltimore, MD |
| Sunday, Sept 14, 2025 | Denver @ Indianapolis | 2:05 PM | Lucas Oil Stadium, Indianapolis, IN |
| Sunday, Sept 14, 2025 | Carolina @ Arizona | 2:05 PM | State Farm Stadium, Glendale, AZ |
| Sunday, Sept 14, 2025 | Philadelphia @ Kansas City | 2:25 PM | GEHA Field at Arrowhead Stadium, Kansas City, MO |
| Sunday, Sept 14, 2025 | Atlanta @ Minnesota | 6:20 PM | U.S. Bank Stadium, Minneapolis, MN |
| Monday, Sept 15, 2025 | Tampa Bay @ Houston | 5:00 PM | NRG Stadium, Houston, TX |
| Monday, Sept 15, 2025 | Los Angeles @ Las Vegas | 8:00 PM | Allegiant Stadium, Las Vegas, NV |
NFL Handicapping Leaderboard
As we move into Week 2 of the 2025 NFL season, excitement continues to build as teams settle into their rhythm. Our Top Handicappers are ready to give you the edge with expert insights and strategies honed over the offseason, ensuring you make informed picks for this week’s slate of games.
This week’s leaderboard reflects a combination of rigorous analysis, in-depth research, and expert intuition. As the season gains momentum, keeping track of top performers will help bettors identify valuable trends and gain a strategic advantage.
NFL Week 2 Picks
Scores and Stats’ seasoned analysts have provided their Week 2 NFL picks, including predictions against the spread, over/under, and money lines. Expect to find a range of profitable betting opportunities that could be placed individually or incorporated into winning parlays and teasers.
Get Ready for Week 2 with Expert Picks from Scores and Stats
Kick off Week 2 of the 2025 NFL season with expert guidance from Scores and Stats. Whether you’re a seasoned pro or new to betting, our comprehensive, data-driven insights will give you the tools to make smarter, more confident decisions as the season progresses.
At Scores and Stats, we’re more than just a betting resource—we’re a community of passionate fans, bettors, and analysts who live and breathe football. Stay up to date by following us on Instagram @scoresandstats, X @scoresand_stats, and YouTube for real-time updates, betting tips, and expert breakdowns of each week’s key matchups.
We are proud to be your go-to source for NFL betting insights. From odds to injury reports and game previews, we provide accurate, actionable content to help you stay ahead of the game. Your feedback shapes our growth, and we’re always here to improve your experience.
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