Indiana vs Iowa Week 5 Odds, Picks & Preview

Iowa Hawkeyes vs Indiana Hoosiers September 27th 2025

The Indiana Hoosiers will take on the Iowa Hawkeyes in Week 5 of the 2025 regular season. This game will be held at Kinnick Stadium in Iowa City. The game is set for Saturday, September 27, 2025, at 3:30 PM and will be broadcast on PEAC.

The Hoosiers come into this game with a perfect 4-0 record. They are ranked #11 in the AP Poll and #12 in the Coaches Poll. On the other hand, the Hawkeyes have a 3-1 record. They have been strong at home with a 2-0 record at Kinnick Stadium. Both teams are part of the Big Ten Conference and have a 1-0 conference record so far this season.

Indiana vs Iowa CFB Key Information

Sport: College Football
Teams: Indiana Hoosiers vs. Iowa Hawkeyes
Venue: Kinnick Stadium in Iowa City, IA
Date: Saturday, September 27, 2025
Betting Odds: Indiana Moneyline -301, Iowa Moneyline +242, Indiana Spread -7.5 (-110), Iowa Spread +7.5 (-110), Total Over 48.5 (-110), Total Under 48.5 (-111)

Indiana vs Iowa Week 5 Betting Preview

The Indiana Hoosiers head to Iowa City to face the Iowa Hawkeyes Saturday for a crucial Big Ten matchup. Indiana is 4–0 (1–0 Big Ten) and coming off a dominant 63–10 win over Illinois. Iowa is 3–1 (1–0) after a 38–28 win at Rutgers.

Indiana leads the nation in rushing yards and has scored 219 points so far. Their defense is top ranked in sacks and interceptions, giving them a well-rounded formula. Iowa counterbalances with strong run offense, a reliable defense, and the home crowd at Kinnick Stadium.

Line Movement and Odds

Spread / total: Indiana is favored by 7.5 points.
Over/Under: 48.5 points.
Moneyline: Indiana ~ –300, Iowa ~ +240.
Line movement & splits: The line opened at –7.5 and has held steady. Public money heavily favors Indiana; some sharp money teases Indiana at +7.5 when available.
ATS trends: Indiana has covered in 12 of its last 14 games when favored.

Matchup Breakdown

Indiana Hoosiers
They dominate the trenches and press the pace. QB Fernando Mendoza has thrown 14 touchdowns with zero interceptions this season, completing nearly 77% of passes. RBs Kaelon Black and Omar Cooper Jr. drive the ground and aerial balance. Their defense ranks in the top tier in sacks and takeaway metrics.

Iowa Hawkeyes
Iowa counters with a strong run game behind Jaziun Patterson and contributions from Gronowski’s legs. Their defensive front is stout and excels in setting the tone at home. Losing kicker Kyle Konrardy hurts late-game scoring.

Key battle
Indiana’s offensive line vs Iowa’s defensive front. If Indiana can sustain drives and avoid three-and-outs in a loud environment, they’ll control the tempo. But Iowa’s edge in crowd noise and defensive toughness can swing momentum.

Injuries and Conditions

Indiana Hoosiers

RB Lee Beebe Jr.: out for season
WR Tyler Powell: out
OL Chubba Maae, RB Kedrick Reescano: listed as questionable

Iowa Hawkeyes

K Kyle Konrardy: out
DL Tamatoa McDonough: questionable

Clear skies are expected in Iowa City, so weather should not influence play.

Best Bets and Prediction

Projected score: Indiana 30, Iowa 20 (50 total)

Best bet: Indiana –7.5
Secondary lean: Over 48.5

Indiana’s offense and depth give them an edge. Iowa will push with physicality and crowd support, but Indiana should carry the day.

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Iowa Hawkeyes vs Indiana Hoosiers Picks and Predictions September 27th 2025