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Kansas vs Missouri Picks and Predictions — September 6, 2025
The Kansas Jayhawks and Missouri Tigers renew one of college football’s fiercest rivalries Saturday night in Columbia, Mo., marking the first Border War meeting since 2011. Missouri won that game 24-10 before leaving the Big 12 for the SEC, and now the 111th edition carries extra energy with both fan bases eager for bragging rights.
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Kansas (2-0) has rolled through its first two contests, while Missouri (1-0) dominated its opener.
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Kansas Can Win If…
The Jayhawks’ offense has been explosive, led by quarterback Jalon Daniels, who has thrown for 456 yards and seven touchdowns while completing 80% of his passes. He’s also added 65 rushing yards, giving Kansas a true dual-threat presence.
Receivers Emmanuel Henderson Jr. and Cam Pickett have combined for five touchdown receptions, and the run game features Daniel Hishaw Jr. (158 yards) and Leshon Williams, who is expected back from injury.
“We believe in doing things the right way. Compete hard on the field, have it settled there,” head coach Lance Leipold said.
If Daniels continues his efficiency and the Jayhawks control tempo, Kansas has a strong chance to snap the skid in the rivalry.
Missouri Can Win If…
Penn State transfer Beau Pribula wasted no time impressing in his debut, throwing for 283 yards and two touchdowns while rushing for 65 yards and two more scores. His dual-threat ability adds balance alongside running back Ahmad Hardy, who ran for 100 yards on just 10 carries in the opener.
Missouri does face adversity, losing kicker Blake Craig for the season and quarterback Sam Horn to a leg injury. But receivers Marquis Johnson and Kevin Coleman give Pribula explosive options.
“Anything that stirs the passion of your fan base is important,” head coach Eli Drinkwitz said, embracing the renewed rivalry.
If Pribula maintains rhythm and Missouri limits Kansas’ big plays, the Tigers can extend their Border War dominance.
Key College Football Betting Trends
| Category | Kansas Jayhawks | Missouri Tigers |
|---|---|---|
| Record | 2-0 (beat Fresno State, Wagner) | 1-0 (beat Central Arkansas 61-6) |
| QB Outlook | Jalon Daniels: 456 yds, 7 TD, 65 rush yds | Beau Pribula: 283 yds, 2 TD, 65 rush yds, 2 rush TD |
| Offensive Notes | Explosive passing and balanced run | Dual-threat QB, strong receiving corps |
| Defensive Outlook | Allowed just 14 pts across 2 games | Allowed 6 pts in opener |
| Series History | Last meeting: 2011, KU lost 24-10 | Leads series, won last 3 meetings |
The Lean
Model Projection: Missouri 31, Kansas 27
Pick: Missouri Moneyline
Total Lean: Over 58
Both teams have firepower at quarterback, but Missouri’s home-field advantage and Pribula’s dynamic skill set could tilt this rivalry renewal. Expect offensive fireworks in a matchup fueled by over a decade of anticipation. For more breakdowns, visit our NCAAF Betting Predictions hub.
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