Ohio State Buckeyes vs Indiana Hoosiers Picks and Predictions December 6th 2025

Last Updated on

The Ohio State Buckeyes face the Indiana Hoosiers in the Big Ten Championship Game at Lucas Oil Stadium in Indianapolis. Both teams enter undefeated at 12-0, making this matchup historic with the No. 1 College Football Playoff seed on the line. Bettors must weigh Ohio State’s defensive dominance against Indiana’s explosive offense led by Fernando Mendoza.

Line Movement and Odds

  • Ohio State MoneyLine: -202
  • Indiana MoneyLine: +168
  • Ohio State Spread: -4.5 (-111)
  • Indiana Spread: +4.5 (-109)
  • Total Over 48.5 (-105)
  • Total Under 48.5 (-116)

Ohio State opened as favorites in this neutral-site clash. See full NCAAF odds for market movement.

sas logo

Every Pick. Every Sport. All Verified

Follow sharp cappers across NFL, NBA, MLB, and more.

Matchup Breakdown

Ohio State Buckeyes Outlook

Ohio State defeated Michigan 27-9 behind Julian Sayin’s 233 passing yards and three touchdowns. Sayin leads the nation in completion percentage (78.9%) with 3,065 yards and 30 touchdowns. Jeremiah Smith (942 receiving yards, 11 TDs) and Bo Jackson (952 rushing yards) provide balance. Defensively, the Buckeyes rank first nationally in scoring defense (7.8 ppg) and total defense (203.0 ypg), anchored by All-American safety Caleb Downs.

Indiana Hoosiers Outlook

Indiana routed Purdue 56-3 with 355 rushing yards. Fernando Mendoza has thrown for 2,758 yards and 32 touchdowns, guiding the Hoosiers to the nation’s second-best scoring offense (44.3 ppg). Roman Hemby adds 866 rushing yards and six scores. Indiana ranks 9th in rushing yards and 5th in total offense (483.8 ypg). Their defense contributes with 34 sacks, ranking 8th nationally, making them a formidable opponent.

Key Matchup / Path to Victory

Ohio State’s elite defense vs Indiana’s high-powered offense. The Buckeyes must pressure Mendoza and limit explosive plays, while Indiana needs Mendoza and Hemby to sustain drives against the toughest defense they’ve faced.

Football
2025-12-18 21:00
Open
Missouri State Bears
Arkansas State Red Wolves
Football
2025-12-20 12:00
Open
Miami Hurricanes
Texas A&M Aggies
Football
2025-12-27 17:45
Open
North Texas Mean Green
San Diego State Aztecs

Injuries / Availability

Ohio State: Mason Maggs (QB), Malik Hartford (S), Logan George (DL), Ahmed Tounkara (DL), Quincy Porter (WR), De’Zie Jones (WR), Maxwell Roy (DT) are questionable.
Indiana: E.J. Williams Jr. (WR), Brendan Franke (K), Drew Evans (OL) are questionable. Bryson Bonds (DB), Tyler Morris (WR), Kellan Wyatt (DL), Lee Beebe Jr. (RB) are out.

  • Ohio State is 28-2 straight up as a favorite in their last 30 games.
  • Ohio State is 8-1 ATS as a favorite in their last 9 games.
  • Ohio State is 6-0 ATS in games with totals ≥ 50 in their last 6 games.
  • Indiana is 22-0 straight up as a favorite in their last 22 games.
  • Indiana is 15-0 straight up in home games in their last 15 games.
  • Indiana is 5-1 ATS as an underdog in their last 6 games.
sas logo

Your Shortcut to the Sharp Side

Watch every verified capper’s move unfold across all major sports

Best Bets and Prediction

Projected Final Score: Ohio State 31, Indiana 24

  • Ohio State -4.5 (-111) → Best Bet. Buckeyes’ defensive dominance and track record as favorites suggest they cover.
  • Over 48.5 (-105) → Total. Our model projects 55 points, leaning over given Indiana’s offensive pace.

Ohio State’s defense should secure the win, but Indiana’s offense makes this a compelling battle. Expect the Buckeyes to cover with the total trending over.

Handicappers and Service Plays

For sharper betting insights, explore our Best Handicappers, track performance streaks on the Leaderboard, and review premium selections in Buy Picks. These resources provide expert context to refine your wagering strategy.

Yesterday
Pro Picks – James
$1,251
2. Scott’s Picks
$722
3. Tyler Williams
$500
4. Sports Central
$454
5. Madjack Sports
$382
This Week
Pro Picks – James
$1,220
2. Freudy Hockey
$1,133
3. Al Grant
$978
4. Jacob Hoffman
$882
5. Bobby Conn
$700
This Month
Sas Insider
$2,539
2. Evan Lewis
$1,704
3. Scott’s Picks
$1,345
4. Oskeim Sports
$1,180
5. Bobby Conn
$1,127