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Jacksonville Jaguars vs Arizona Cardinals Betting Preview
The Jacksonville Jaguars visit the Arizona Cardinals at State Farm Stadium in Week 12 NFL action. Jacksonville enters at 6-4, riding momentum from a dominant win over the Chargers, while Arizona sits at 3-7 after dropping seven of their last eight. Bettors will weigh the Jaguars’ playoff push against the Cardinals’ inconsistency and injury concerns.
Line Movement and Odds
- Jaguars Spread: -2.5 (-110)
- Cardinals Spread: +2.5 (-110)
- Jaguars MoneyLine: -149
- Cardinals MoneyLine: +125
- Total: 47.5 (Over -124, Under +103)
Jacksonville opened as a slight road favorite, reflecting their playoff positioning and Arizona’s struggles at home. See full NFL odds for market movement.
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Matchup Breakdown
Jacksonville Jaguars Outlook
Trevor Lawrence threw for 153 yards and a touchdown in the win over Los Angeles, while Travis Etienne and Bhayshul Tuten combined for 147 rushing yards and three scores. Jacksonville’s defense limited the Chargers to just 135 total yards and eight first downs. The Jaguars rank top-10 in turnover margin (+8) and have shown strength in the ground game. Injuries to Etienne (shoulder), Tuten (ankle), and WR Brian Thomas Jr. (ankle) are worth monitoring, but depth has carried them through.
Arizona Cardinals Outlook
Jacoby Brissett threw for a career-high 452 yards and two touchdowns against San Francisco, but Arizona committed 17 penalties and three turnovers. WR Michael Wilson posted 185 yards on 15 catches, while Marvin Harrison Jr. remains sidelined after appendix surgery. The Cardinals’ passing game has improved, but their defense has struggled to contain opponents. RB Emari Demercado (ankle) is out, while Trey Benson could return from IR. Arizona must cut down on mistakes to stay competitive.
Key Matchup / Path to Victory
The Jaguars must continue leaning on their rushing attack and defensive pressure, with Josh Hines-Allen and Arik Armstead anchoring the front. The Cardinals need Brissett and Wilson to sustain drives while avoiding turnovers. Discipline and ball security will be decisive in this matchup.
Injuries / Availability
Jacksonville lists Brian Thomas Jr. (ankle), Bhayshul Tuten (ankle), and Travis Etienne (shoulder) as questionable, with Eric Murray (neck) and Cooper Hodges (knee) out. For full player status, check the Jaguars injury report.
Arizona lists Marvin Harrison Jr. (appendix), Emari Demercado (ankle), James Conner (foot), and Kyler Murray (foot) out, with Kelvin Beachum (groin) and Jonah Williams (shoulder) questionable. See the Cardinals injury page for latest updates.
Environment
The game kicks off at State Farm Stadium, where Arizona is 1-4 at home. Jacksonville is 2-2 on the road, aiming to solidify their playoff position. Expect the Jaguars’ rushing attack to clash with Arizona’s pass-heavy offense in a high-paced contest.
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Best Bets and Prediction
Projected Final Score: Jaguars 28, Cardinals 24
- Best Bet: Jaguars -2.5
Jacksonville’s balanced offense and defensive edge make them the pick to cover. - Total: Over 47.5 (-124)
Our model projects 52 points, leaning over given both teams’ recent scoring trends.
Jacksonville’s playoff push should carry them to victory, but Arizona’s passing game keeps it close. Expect a competitive, high-scoring matchup trending over the total.
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