Arizona Cardinals vs Seattle Seahawks Picks and Predictions September 25th 2025

Arizona Cardinals vs Seattle Seahawks Football Thu, Sep 25, 19:15 pm.
Arizona Cardinals
ML: 110
0
0
Seattle Seahawks
ML: -133
Last Updated on

Cardinals RB Trey Benson Thrust Into Spotlight vs Seahawks — Week 4 Preview

The Arizona Cardinals head into a prime time matchup at home Thursday night vs. the Seattle Seahawks (8:15 PM ET, Glendale), needing to regroup after the loss of their veteran back, James Conner. With Conner placed on injured reserve, second‑year back Trey Benson is elevated into a featured role in what’s shaping up as a vital NFC West showdown.

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Cardinals Can Win If…

  • Benson handles the load without missing a beat. He’s averaged ~5.95 ypc so far and will need to help maintain balance to relieve pressure from Kyler Murray.
  • The defense holds Seattle in check. Arizona ranks tied for 5th in points allowed (~17 PPG), so if they force turnovers or key stops, they can control field position.
  • Murray and the passing game execute in rhythm. With the ground game less certain, Kyler needs to avoid mistakes and target matchups down the field to keep drives alive.

“Picking up that slack … we have to collectively do it,” said Coach Jonathan Gannon about replacing Conner.

Seahawks Can Win If…

  • Their offense stays efficient and opportunistic. Sam Darnold has shown growth, and Seattle’s balance (run + pass) gives them flexibility.
  • Special teams and defense make big plays. Seattle blocked a punt and had a long punt return TD in their last win, shifting momentum.
  • Matchup advantages exploited. If Arizona’s secondary or linebackers struggle, Seattle may find lanes — especially with some injury uncertainty on both sides.

Key NFL Betting Trends & Game Context

CategoryCardinalsSeahawks
Current Record2‑12‑1
Recent TrendLoss last week; Conner IR adds urgencyTwo straight wins, including big special plays
Rushing GameNow anchored by Benson, not ConnerKenneth Walker & combo run/pass mix
Defensive StrengthTop 5 in points allowedOpportunistic with potential in pass rush
Injury / Roster WatchLost Conner; Zay Jones, Beachum, Johnson limitedSome ankle issues, but many back in limited practice

The Lean

Pick: Cardinals Moneyline
Projected Final Score: Cardinals 24, Seahawks 21
Total Lean: Over 43.5

Despite the hit to the backfield, Arizona’s defense and home field give them a shot to squeak this out. Expect Trey Benson to surprise, and Murray to get timely completions. The Seahawks’ special teams and momentum are real wildcards. Lean to Arizona ML + the over — this one should stay competitive to the final possession.

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Best Bet Box

CategoryDetail
Best BetCardinals ML
Confidence Rating★★★★☆
Projected ScoreCardinals 24, Seahawks 21
Total LeanOver 43.5
Market SplitStronger backing on Cardinals side
Line MovementSlight support shift toward Arizona
TrendArizona’s defense remains elite; Seattle thrives on plays
Prop HighlightTrey Benson Over Rushing Yards