Baltimore Ravens vs Detroit Lions Picks and Predictions September 22nd 2025

Lions vs Ravens Picks and Predictions — Week 3, Monday Night Football

Lamar Jackson has been nearly untouchable under the Monday night lights. The Baltimore Ravens (1-1) host the Detroit Lions in a Week 3 primetime clash at M&T Bank Stadium, where both teams bring top-tier offenses and playoff aspirations.

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Jackson enters this matchup with 22 passing touchdowns and zero interceptions in nine career MNF games. Detroit, meanwhile, is fresh off a 52-21 demolition of the Bears, with Jared Goff tying his career high with five touchdown passes.

Both teams rank inside the NFL’s top 3 in scoring, setting the stage for a high-powered shootout on Monday Night Football.

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The Lions Can Win If…

The Lions proved in Week 2 that they can overwhelm defenses with explosive plays. Jared Goff was nearly flawless, going 23-of-28 for 334 yards and five TDs, while Amon-Ra St. Brown and Jameson Williams combined for over 200 receiving yards and four scores.

Detroit’s offense remains elite:

• 1st in scoring last season (564 points)
• 2nd in passing yards (4,474)
• 4th in third-down conversion rate (47.6%)

Defensively, the Lions force turnovers. Their 16 interceptions last season ranked 4th in the NFL, giving them the ability to swing momentum against high-powered opponents like Baltimore.

If Goff maintains his accuracy and Detroit wins the turnover battle, they have the tools to pull the upset.

The Ravens Can Win If…

Lamar Jackson thrives under the MNF spotlight, and he enters this game with six passing touchdowns and one rushing score through two weeks. In last week’s 41-17 win over the Browns, Jackson was surgical with four TD passes.

Baltimore’s offense thrives on balance:

• 1st in rushing yards last season
• 3rd in scoring
• Derrick Henry projects for 95+ rushing yards in this matchup

Defensively, injuries are a concern, with Kyle Van Noy sidelined and key players banged up. But if Jackson continues his Monday dominance and Henry establishes the ground game, the Ravens can control the tempo.

Key NFL Betting Trends

The Lean

Model Projection: Ravens 28, Lions 27
Best Bet: Lions +5.0 (-108)
Total Lean: Over 52.5 (-111)

Detroit’s offense is firing on all cylinders, and their 7-1 ATS record on the road makes them the sharper side. Expect Lamar Jackson to deliver in primetime, but the Lions have enough firepower to keep this within a field goal.

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