Cowboys vs Panthers – NFL Week 6 Betting Preview & Predictions

Carolina Panthers vs Dallas Cowboys October 12th 2025

The Dallas Cowboys will visit the Carolina Panthers for a Week 6 game in the 2025 NFL season. The game will take place at Bank of America Stadium in Charlotte, NC, on Sunday, October 12, at 1:00 PM. Fans can catch the action on FOX, with the weather expected to be mild with scattered clouds and a light breeze.

The Cowboys, led by head coach Brian Schottenheimer, have a season record of 2-2-1. They have a road record of 1-2-0. The Panthers, coached by Dave Canales, hold a 2-3-0 record and are undefeated at home with a 2-0-0 record. In recent head-to-head games, the Cowboys have had the upper hand, winning the last two meetings at Bank of America Stadium.

Cowboys vs Panthers Key Information

Sport: NFL
Teams: Dallas Cowboys vs. Carolina Panthers
Venue: Bank of America Stadium in Charlotte, NC
Date: Sunday, October 12, 2025
Betting Odds: Cowboys Moneyline -182, Panthers Moneyline +152, Cowboys Spread -3.5 (-102), Panthers Spread +3.5 (-118), Total Over 49.5 (-111), Total Under 49.5 (-110)

Cowboys vs Panthers – NFL Week 6 Betting Preview

The Dallas Cowboys continue to find rhythm under Brian Schottenheimer’s offense, while the Carolina Panthers look to extend their home success in Week 6.

Dak Prescott has Dallas firing on all cylinders after back-to-back offensive outbursts, while Carolina will rely on Rico Dowdle and Bryce Young to pull off another home upset.

The Cowboys can win if

They maintain balance between Dak Prescott’s precision and Javonte Williams’ power. Prescott ranks first in the NFL with 1,356 passing yards and 10 touchdowns, while Williams leads the league in rushing yards (447) and rushing scores (5).

Schottenheimer’s game plan has emphasized tempo and diversity — with four different players leading Dallas in receiving yards over the past four games. Against Carolina’s defense, which has allowed the most opponent offensive yards in the league, that versatility should be decisive.

Defensively, the Cowboys’ front remains fierce. With Dante Fowler Jr. and Sam Williams generating interior pressure, Dallas ranks top-five in sacks per game. If the defense limits Carolina’s early ground success, the Cowboys can pull away by halftime.

The Panthers can win if

They replicate their dominant ground performance from Week 5. Rico Dowdle exploded for 206 rushing yards and a touchdown against Miami, earning NFC Offensive Player of the Week honors. If Chuba Hubbard returns, coach Dave Canales could rotate the duo to control time of possession.

Quarterback Bryce Young has been efficient in red-zone situations, tossing two touchdowns last week without an interception. His play-action ability is the key against a Cowboys defense that’s more susceptible to the pass than the run — ranking last in the NFL at 284.6 passing yards allowed per game.

At home, Carolina has been strong — posting a 2-0 record, including a 30-0 rout of Atlanta. If the Panthers start faster and maintain defensive discipline, they could turn this matchup into a fourth-quarter grind.

Line Movement and Odds

Opening: Cowboys -2.5 / Panthers +2.5
Current: Cowboys -3.5 / Panthers +3.5
Total: 49.5 points

Dallas opened as a small road favorite, but sharp action pushed the line to -3.5 following their dominant win over the Jets. Both teams have trended toward the over this season, but the model’s 47-point projection slightly favors the under.

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Matchup Breakdown

The Cowboys’ offense currently ranks second in scoring (31.6 PPG) and third in total yards per game (398.2). Prescott’s quick-release passing complements Williams’ physical running, and Dallas’ offensive line has allowed only five sacks through five weeks.

Carolina’s defense has been inconsistent — capable of forcing three fumbles one week, then surrendering 37 points the next. Their pass defense has shown promise, but the front seven must limit Williams and force Prescott into third-and-long situations to stay competitive.

For full statistical comparisons and matchup data, visit the NFL teams page and check the Expert Betting Guide for advanced breakdowns.

Injury Report

Dallas Cowboys

WR Ceedee Lamb (ankle) – out
OT Tyler Guyton (concussion) – probable
RB Tony Pollard (shoulder) – questionable
DE Sam Williams (foot) – probable
LB Leighton Vander Esch (neck) – IR

Carolina Panthers

RB Chuba Hubbard (ankle) – questionable
CB Jaycee Horn (hamstring) – out
WR Jonathan Mingo (groin) – probable
DE Brian Burns (shoulder) – questionable

Weather in Charlotte: 71°F, light wind — minimal weather impact.

Prop Spotlight

Dak Prescott Over 1.5 Passing TDs (-125)
Prescott has thrown multiple touchdowns in four of his last five games and faces a defense giving up 267 passing yards per contest.

Rico Dowdle Over 69.5 Rushing Yards (-115)
Dowdle should see consistent touches even if Hubbard returns. Dallas’ defense ranks middle-of-the-pack against the run, making this prop appealing.

Best Bets and Prediction

Dallas has the superior offense, deeper defensive front, and proven road form to control this matchup. Carolina’s rushing game keeps it competitive early, but Prescott’s efficiency gives the Cowboys separation in the second half.

Prediction: Cowboys 27, Panthers 20
Best Bet: Cowboys -3.5 (-110)
Secondary Lean: Under 49.5 (-110)

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Carolina Panthers vs Dallas Cowboys Picks and Predictions October 12th 2025