Denver Broncos vs Tennessee Titans Picks and Predictions September 7th 2025

Rookie Quarterback Debuts in Denver

The Tennessee Titans are set to open the 2025 season on the road against the Denver Broncos, ushering in the Cam Ward era. Selected with the No. 1 overall pick, Ward is expected to bring hope to a franchise coming off a 3-14 campaign. Head coach Brian Callahan has emphasized patience, saying the Titans need Ward to simply play good football and rely on his teammates rather than shoulder the entire burden.

Ward completed 10 of 19 passes for 145 yards during preseason action, highlighted by a 13-play touchdown drive in the team’s win over Minnesota on Aug. 22. With Will Levis sidelined for the season due to a lingering shoulder injury, Ward takes the reins with veterans Brandon Allen and Trevor Siemian serving as his backups. Fans looking for more insight into this matchup can visit the NFL previews page

Denver’s Stability with Bo Nix

The Broncos enter Week 1 with far different expectations. Quarterback Bo Nix, last year’s No. 12 overall pick, delivered a standout rookie season with 3,775 passing yards, 29 touchdowns, and only 12 interceptions while adding 430 rushing yards and four more scores. Nix helped Denver reach the AFC playoffs and gave the franchise a strong sense of stability at the position.

With every offensive line starter returning and a defensive front that fueled a league-high 63 sacks in 2024, Denver looks poised to challenge Kansas City for the AFC West crown. For updated spreads, totals, and lines across the league, check the NFL scores and odds page

Land a Touchdown!

With our Premium Handicapping Membership

Get Free Trial

Titans Lean on Tony Pollard

If Tennessee hopes to keep pace, running back Tony Pollard will likely be a focal point. Pollard rushed for 1,079 yards and added 41 receptions last season, providing one of the few bright spots in an otherwise disappointing year. Establishing the run could help Ward settle in against Denver’s aggressive pass rush.

Ward has expressed confidence in his ability to lead the offense, noting his belief that he can throw effectively and guide the Titans to consistent scoring. Fans can track performance trends and game breakdowns by checking the NFL expert betting guide

Series History and Betting Outlook

The Titans hold a 25-18-1 edge in the all-time series, including a 17-10 victory in their most recent meeting three years ago. However, with Denver’s defensive front intact and Tennessee’s offensive line still a question mark, the Broncos present one of the most challenging scenarios for a rookie quarterback.

For bettors and fans, this matchup is a study in contrasts: a franchise quarterback entering his sophomore campaign versus a top pick making his debut. To follow expert insights and player matchups, check out NFL picks. You can also explore team breakdowns on the NFL teams page shop for premium picks and monitor top performers on the best handicappers leaderboard