Jacksonville Jaguars vs Seattle Seahawks Picks and Predictions October 12th 2025

Jacksonville Jaguars vs Seattle Seahawks October 12th 2025

The Seattle Seahawks travel to EverBank Stadium to face the Jacksonville Jaguars in Week 6 of the 2025 NFL season. The game kicks off on Sunday, October 12, at 1:00 PM and will be broadcast on FOX. Fans can expect a mild day with a clear sky and a light breeze, perfect for outdoor football.

The Seahawks come into this game with a 3-2 record and have been strong on the road, winning both of their away games. Head Coach Mike Macdonald and his team will look to maintain their road success. The Jaguars, led by Head Coach Liam Coen, boast a 4-1 record and have been unbeaten at home this season. Jacksonville’s home advantage could play a key role in this matchup.

Seahawks vs Jaguars Key Information

• Sport: NFL
• Teams: Seattle Seahawks vs. Jacksonville Jaguars
• Venue: EverBank Stadium in Jacksonville, FL
• Date: Sunday, October 12, 2025
• Betting Odds: Seahawks Moneyline +101, Jaguars Moneyline -120, Seahawks Spread +1.5 (-113), Jaguars Spread -1.5 (-108), Total Over 46.5 (-109), Total Under 46.5 (-111)

Seahawks vs Jaguars – NFL Week 6 Betting Preview

The Seattle Seahawks travel cross-country to face the Jacksonville Jaguars in a matchup between two of the NFL’s most improved offenses.

Seattle (3-2) nearly pulled off an upset over Tampa Bay last week before falling 38-35, while Jacksonville (4-1) stunned Kansas City in a Monday night thriller, 31-28. Both teams feature balanced offensive attacks — but it’s the Jaguars’ takeaway-heavy defense that could decide this one

The Seahawks can win if

Sam Darnold maintains his rhythm and limits turnovers. The veteran quarterback is coming off his best performance of the season — 341 passing yards and four touchdowns — and ranks seventh in the NFL in yardage (1,246) through five weeks.

Darnold’s connection with Jaxon Smith-Njigba has been electric. The second-year receiver ranks second in the league with 534 receiving yards and has become a matchup nightmare against zone coverage.

Seattle’s defense can also swing the game. The Seahawks rank third against the run (83.0 yards per game) and still boast one of the most aggressive front sevens in football. If they can force Trevor Lawrence into third-and-longs and limit Travis Etienne’s open-field space, Seattle has the tools to steal a road win.

The Jaguars can win if

Trevor Lawrence and the Jacksonville secondary continue their clutch playmaking. Lawrence accounted for two touchdowns in last week’s victory over Kansas City — including a game-winning scramble in the final seconds — while the Jaguars’ defense sealed the game with a Devin Lloyd interception return.

Lloyd now leads the NFL with four interceptions, and Jacksonville’s defense ranks first in takeaways (10). The Jaguars’ run game, powered by Travis Etienne Jr. (fourth in rushing yards), has also helped balance their offense and take pressure off Lawrence.

However, Jacksonville will be without tight end Brenton Strange (hip), while wide receiver Dyami Brown and running back Bhayshul Tuten remain questionable. The Jaguars must continue finding success with quick passes and yards-after-catch production to counter Seattle’s elite front.

Line Movement and Odds

Opening: Jaguars -1 / Seahawks +1
Current: Jaguars -1.5 / Seahawks +1.5
Total: 46.5 points

The slight line movement toward Jacksonville reflects home-field advantage and Seattle’s defensive injuries. Still, the Seahawks have covered in six straight road games, and Darnold has been efficient as an underdog.

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Matchup Breakdown

Seattle’s offense ranks top-10 in passing yards and red-zone scoring percentage. The combination of Darnold’s accuracy and Kenneth Walker III’s balance (330 rushing yards) gives them multiple scoring threats.

Jacksonville’s defense, while opportunistic, ranks just 27th in passing yards allowed (250.4 per game). Expect Darnold to attack deep and test the Jaguars’ corners early.

The Jaguars’ edge comes from their ball-hawking defense — they’ve scored three defensive touchdowns in five games — and their home advantage. Still, Seattle’s ability to win on the road against top-tier teams keeps this game within one score.

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Injury Report

Seattle Seahawks

• CB Devon Witherspoon (knee) – out
• LB DeMarcus Lawrence (quad) – doubtful
• LB Derick Hall (oblique) – questionable
• S Julian Love (hamstring) – out

Jacksonville Jaguars

• TE Brenton Strange (hip) – IR
• WR Dyami Brown (shoulder) – questionable
• RB Bhayshul Tuten (shoulder) – questionable
• DE Travon Walker (wrist) – questionable

Weather in Jacksonville: 80°F and humid, with potential for light showers — moderate impact on passing totals.

Prop Spotlight

Jaxon Smith-Njigba Over 70.5 Receiving Yards (-115)
Smith-Njigba has eclipsed 100 yards in back-to-back games and faces a Jacksonville secondary ranked bottom five in passing yards allowed.

Travis Etienne Jr. Anytime TD (+110)
Etienne has scored in three of the Jaguars’ last four games and is averaging 21 touches per contest.

Best Bets and Prediction

Seattle’s road form and Darnold’s improved efficiency make this matchup tighter than the spread suggests. Jacksonville’s turnover-heavy defense could create chaos, but Seattle’s balanced offense has the experience to weather momentum swings.

Prediction: Seahawks 24, Jaguars 21
Best Bet: Seahawks +1.5 (-113)
Secondary Lean: Under 46.5 (-111)

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