New Orleans Saints vs Arizona Cardinals Picks and Predictions September 7th 2025

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A New Era Begins in New Orleans

Kellen Moore will step onto the Caesars Superdome sideline Sunday in a much different role than the last time he was there. Earlier this year, he helped guide the Philadelphia Eagles to a Super Bowl LIX victory as their offensive coordinator. Now, the 37-year-old Moore begins his tenure as the youngest head coach in the NFL, taking charge of the New Orleans Saints in their season opener against the Arizona Cardinals.

Moore inherits a franchise coming off a 5-12 campaign and four consecutive seasons without a playoff appearance. With a fresh start, he emphasized fundamentals for Week 1: tackling, blocking, communication, and staying composed in uncertain situations. Fans and bettors following NFL previews will be watching closely to see if Moore can inject early optimism into the rebuild.

Spencer Rattler Takes the Reins

Second-year quarterback Spencer Rattler will be the centerpiece of this new era. After going 0-6 as a fill-in starter last year, he won a tight preseason battle against rookie Tyler Shough to earn the full-time role. Moore praised Rattler’s calm confidence, believing it sets the tone for leadership in the huddle.

Rattler, a Phoenix native, will open his first full season as a starter against his hometown Cardinals, with family and friends expected in attendance. For those tracking NFL picks, the spotlight on Rattler’s development adds intrigue to this matchup.

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Veterans Still Anchoring the Saints

While the Saints are viewed as a rebuilding team, several veterans remain pivotal to their success. Running back Alvin Kamara, defensive end Cameron Jordan, and linebacker Demario Davis provide experience and leadership. Their contributions will be crucial as Moore and his young quarterback attempt to establish a new identity.

For bettors exploring NFL scores and odds this mix of veteran presence and unproven talent creates uncertainty around New Orleans’ outlook.

Cardinals Further Along in Their Rebuild

The Cardinals provide a strong contrast to the Saints’ situation. Under head coach Jonathan Gannon, Arizona improved from 4-13 in his first season to 8-9 last year. Now entering his third season, Gannon believes his team is ready to take another step forward.

Arizona holds a clear edge at quarterback with Kyler Murray, who is entering his seventh season. Gannon highlighted Murray’s growth in command and decision-making, noting his ability to process the game at a faster pace. That advantage could play a defining role in Sunday’s contest.

Defensive Upgrades for Arizona

The Cardinals bolstered their defensive front in the offseason, signing Josh Sweat from Philadelphia, former Browns tackle Dalvin Tomlinson, and veteran Calais Campbell, who returns to the franchise where he began his career. Gannon emphasized that stopping the run and pressuring opposing quarterbacks will be the keys to defensive success.

For a deeper perspective, fans can check the expert NFL betting guide to understand how these offseason moves may impact Arizona’s performance against New Orleans.

Injury Updates

The Saints enter the opener with some injury concerns. Left guard Trevor Penning missed practice with a toe issue, while defensive end Chase Young (calf) and cornerback Alontae Taylor (groin) were limited. For Arizona, backup guard Will Hernandez was limited due to a knee injury.

Keeping track of rosters and health will be critical for evaluating both sides, and the NFL team pages offer up-to-date insights throughout the season.

Betting Outlook and Final Thoughts

This matchup presents two teams in different phases of development. The Saints are launching a rebuild under Moore with Rattler at quarterback, while the Cardinals appear ready to push toward contention with Murray and a revamped defensive front.

For those following the betting markets, make sure to consult the buy picks page and the best handicappers leaderboard to find expert insights before making any wagers.

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