Chiefs vs Giants Week 3 Betting Preview

The Kansas City Chiefs head to MetLife Stadium to face the New York Giants on Sunday, September 21, 2025, in a primetime Week 3 matchup. Kickoff is set for 8:20 PM ET on NBC Sunday Night Football.

Both teams are winless at 0-2, making this a pivotal game. For Patrick Mahomes, it’s the first time in eight seasons as a starter that he’s opened 0-2. He turned 30 this week and called the start “new territory,” but also “an opportunity to prove who we are as the Kansas City Chiefs.”

The Giants fell in overtime to Dallas last week despite Russell Wilson’s 450 passing yards. Head coach Brian Daboll insists Kansas City “doesn’t look like a winless squad,” pointing to their consistency over the past decade.

The history favors New York, which leads the series 11–4, though Kansas City has taken two of the last three.

Line Movement and Odds

Kansas City opened as a 6-point favorite, and the spread has nudged to −6.5 at most books. The moneyline sits around Chiefs −284, Giants +231, with the total steady at 45.5 points.

The move came after early sharp action backed Kansas City, while public bettors leaned toward New York following their near-upset in Dallas. The total ticked slightly upward from 45, reflecting respect for Mahomes’ ability to generate points even in close losses.

For real-time shifts, check our NFL Odds page.

Matchup Breakdown

Chiefs Outlook:
Kansas City has started 0-2 for the first time since 2014. Both losses were tight — 27-21 to the Chargers in Brazil and 20-17 to the Eagles in a Super Bowl rematch. Mahomes passed for 187 yards and one touchdown last week, while Travis Kelce remains the most dependable target. Rookie Tyquan Thornton added a score, but the passing game has lacked its usual explosiveness. The run game (121 yards vs. Philadelphia) offers a clear path against a Giants defense allowing nearly six yards per carry.

Giants Outlook:
New York showed resilience in the 40-37 overtime loss to Dallas. Russell Wilson threw for 450 yards and three touchdowns, while WR Wan’Dale Robinson posted a career-high 142 yards. Rookie Malik Nabers stretches coverage and adds a vertical element. The concern is defense: ranked 27th in points allowed (30.5 ppg) and last in total yards (455 ypg). Without improvement, home-field advantage may not be enough.

Key Battle in the Trenches:
The Giants have surrendered six sacks in two games and still await LT Andrew Thomas, who may debut after foot surgery. Kansas City’s front is thinned with Mike Danna (quad) and Kristian Fulton (ankle) sidelined in practice. If New York protects Wilson, they can challenge downfield. If not, Mahomes will have short fields and extra possessions.

Injuries and Conditions

New York Giants

LT Andrew Thomas – foot, limited, possible season debut.
WR Wan’Dale Robinson – foot, limited, expected to play.
LB Demetrius Flannigan-Fowles – calf, upgraded to limited.
DL Chauncey Golston – ankle, out.
LB Darius Muasau – concussion/eye, out.

Check the full New York Giants injury report for the latest status.

Kansas City Chiefs

WR Rashee Rice – suspended, out.
WR Xavier Worthy – shoulder, limited, game-time call.
WR Jalen Royals – knee, limited, trending active.
QB Patrick Mahomes – wrist, full practice, no restrictions.
DE Mike Danna – quad, did not practice.
CB Kristian Fulton – ankle, did not practice.

See more updates on the Kansas City Chiefs injury report.

Weather Forecast:
Sunday night in East Rutherford will be mild, with temps in the mid-60s, overcast skies, and winds under 8 mph. No rain is expected, and conditions should allow for a clean passing game.

Best Bets and Prediction

Kansas City hasn’t started 0-3 since before Mahomes took over, and history suggests they respond well as favorites. The Chiefs are 10-1 ATS in their last 11 games when laying points, and their run game matches up well against a Giants defense giving up nearly six yards per carry.

New York will lean on Russell Wilson to attack downfield, but the absence of defensive starters and uncertainty around Andrew Thomas at left tackle tilt the matchup toward Kansas City.

Projected Score: Chiefs 28, Giants 17
Best Bet: Chiefs −6.5
Secondary Lean: Under 45.5

Handicappers and Service Plays

Numbers tell part of the story, but the sharpest edge comes from following proven handicappers. The Handicapper Leaderboard shows every record in real time, so you know which NFL experts are heating up and which ones are trending cold.

Each wager is tracked against the closing line with full transparency. No edits, no filters — every win and loss is displayed. You can also compare expert cards inside the Football Picks section before placing your own bets.

New York Giants vs Kansas City Chiefs Picks and Predictions September 21st 2025