While the NCAA Tournament provides beloved drama year after year (well, almost), one thing that bettors are looking for are “sure things”. While those certainly don’t exist in this setting (Michigan State vs MTSU) there are games that are foregone conclusions. Here are the four favorites you should feel comfortable with in the round of 64.

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Georgia Tech vs. Loyola-Chicago Picks

Georgia Tech vs. Loyola-Chicago Betting Report

Best Bet: Loyola-Chicago -5.5

This game went from possibly the best game in the opening round to over before it even started. Atlantic Coast Conference Player of the Year Moses Wright will not be available for the game after a positive COVID test and leaves the Yellow Jackets with zero legitimate options in the front court.

Wright is Georgia Tech’s leading scorer, rebounder and shot blocker, plays 35 minutes per game on the season. Josh Pastner’s other big man option, Rodney Howard, has played in just 18 of their 25 games and averages just 7.6 minutes per game and averages almost as many fouls (1.5) as points (1.6).

Loyola’s heart and soul is big man Cameron Krutwig an All-American who is a beast of a human being and will present huge issues for the Jackets defense. The Ramblers are also the number one team in the nation in adjusted defensive efficiency while also keeping opponents off the offensive glass.

The Jackets are in for a long afternoon.

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Hartford vs. Baylor Picks

Hartford vs. Baylor Betting Report

Best Bet: Baylor -25.5

Normally, you would like to stay away from such a large spread but people not in this instance. People are beginning to doubt the Baylor Bears and they have surely heard about it as they sit in their hotel rooms with nothing but twitter to keep them company.

Hartford is already bad on offense, ranking 293rd in the nation in points per game and 254th in adjusted offensive efficiency. Meanwhile, Baylor is third in the nation in adjusted offensive efficiency while also holding teams (mostly Big 12 teams) to just 66.4 points per game.

Baylor’s average point differential is already 18 points per game and now they get a 16 seed from the America East as a first round appetizer. Expect the best guard trio in the nation in Butler, Teague, and Mitchell to have huge games on the offensive end while Mark Vital fills every column in the stat sheet. The Bears should win this game by 30+ points.

Expert March Madness Picks

Colgate vs. Arkansas Picks

Colgate vs. Arkansas Betting Report

Best Bet: Arkansas -8.5

Look, there has been a TON of conversation regarding this matchup and the potential big time upset. What that almost always means is that the major upset won’t come from this game. It’s usually the game you never expect that jumps up to burn your bracket.

Colgate can certainly put up points, the Raiders are second in the nation in points per game at over 86 per contest but you have to take into account who they have played. The best opponent that Matt Langel’s team has face this year is Army who ranks 189th in the Kenpom rankings. That would be 171 spots below the Razorbacks.

Expect the length, athleticism and overall talent that the “Muss Bus” is going to put on the floor to give the Raiders fits as they have zero size. Find your upset elsewhere.

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Liberty vs. Oklahoma State Picks

Liberty vs. Oklahoma Betting Report

Best Bet: Oklahoma State -9.5

Simply put, the Cowboys have Cade Cunningham. Liberty is a nice team and Ritchie McKay has made this basketball program a consistent fixture in mid-major talks over the last few seasons but this isn’t happening.

Oklahoma State is currently rolling as some youngsters and role players have seemingly come into their own recently. Kalib Boone has really blossomed in recent weeks, averaging 11.7 points, 6.1 rebounds and 2.3 blocks per game in the Pokes last nine games. Avery Anderson has a propensity for big games as well, recently scoring 31 points against West Virginia in a Cowboy’s victory in which Cunningham was out.

Liberty is not great on defense and doesn’t turn their opponents over often and it’s a bad time to face Mike Boynton’s team. Cowboys roll here