Another weekend of Major League Baseball is set to begin and there is a loaded schedule on Friday night. There are some great betting opportunities throughout the league, especially when you look at different betting types.

MLB Sportsbooks

Looking at the entire slate of MLB games can be a bit overwhelming, but we have picked out for bets to focus on. Here are the MLB best bets to make on Friday, May 13.

Moneyline: San Diego Padres +120

Padres vs. Braves Predictions

The San Diego Padres are visiting the Atlanta Braves on Friday to begin a three-game weekend series. This could be a potential playoff preview in the National League, and the pitching matchup in this game will be tremendous.

Yu Darvish starts for the Padres and he will be opposed by Max Fried of the Braves. Both pitchers are capable of having a great performance, and the difference will be the lineup for the Padres.

This game should be tight, but Darvish outduels Fried and the Padres (-120) win.

MLB Betting Odds

Run Line: Cincinnati Reds -1.5 (+150)

Reds vs. Pirates Predictions

After a miserable start to the 2022 MLB season, the Cincinnati Reds are suddenly red-hot. Cincinnati has won five of seven games, including the series opener against the Pittsburgh Pirates.

The pitching matchup for this game favors the Reds also as Tyler Mahle will be on the mound. Pittsburgh always seems to struggle to get outs, and they don’t have the offense to keep up either.

Cincinnati will stay hot with another win, and they take this game by at least two runs.

Game Total: Cubs / Diamondbacks Over 8.5 (-110)

Cubs vs. Diamondbacks Predictions

The Chicago Cubs and Arizona Diamondbacks start a series on Friday night, and this could be a competitive series. Arizona has gotten off to a solid start in 2022, but the Cubs have shown they are capable as well.

The pitching matchup for this game appears pretty even, although neither team will be sending out a front-line start. Instead of trying to predict which team will come out on top, the pitching matchup gives us a chance to look at the total.

8.5 runs is a pretty high total, but there will be plenty of offense in this game. Take the over 8.5 runs as it might take six runs to win the game.

Expert MLB Picks

Parlay: Milwaukee Brewers -140 / New York Yankees -165

Brewers vs. Marlins Predictions / Yankees vs. White Sox Predictions

Putting together a two-team parlay can lead to an even bigger win when betting on baseball, and there are still some great games to focus on. The Milwaukee Brewers take on the Marlins down in Miami, and the Yankees are in Chicago to take on the White Sox.

Milwaukee leads the NL Central Division, and they are sending Corbin Burnes to the mound in this game. Burnes is the reigning NL Cy Young Award winner, and he will pitch his team to a victory.

The Yankees are red-hot, and that offense is clicking on all cylinders. The Chicago White Sox are a solid team as well, but New York will have Gerrit Cole making the start on Friday night.

Cole leads the Yankees (-165) to a win, and adding the Brewers (-140) to the bet will make this a a solid two-team parlay.