Houston Astros vs Cincinnati Reds Picks and Predictions May 10th 2025

Astros Look to Extend Winning Momentum Behind McCullers’ Comeback Start

The Houston Astros are seeing their pitching rotation come full circle, and the spotlight this weekend is firmly on Lance McCullers Jr. as he prepares for his second start of the 2025 season. After a long road to recovery, McCullers is back and ready to build on his first outing, helping to anchor a pitching staff that’s quietly becoming one of the best in the American League.

Hunter Brown Sets the Tone in Series Opener

On Friday night, Hunter Brown led the Astros to a 3-0 shutout victory over the Cincinnati Reds, falling just one out short of pitching six full innings for the eighth time this season. His consistency has been a boon for Astros manager Joe Espada, who has been able to leverage a stellar bullpen effectively thanks to Brown’s inning-eating performances.

Bullpen Brilliance Powering Houston’s Success

Houston’s bullpen has been a cornerstone of their early-season strength. Heading into Saturday’s game, the Astros own the second-lowest bullpen ERA in the American League (2.73), a testament to the staff’s depth and discipline.

“The bullpen has given us the flexibility to be aggressive,” said Espada. “And having starters like Brown deliver deep starts helps us manage those arms efficiently.”

Lance McCullers Jr.: Second Start After Long Layoff

McCullers made his long-awaited return last Sunday against the Chicago White Sox, marking his first appearance since Game 3 of the 2022 World Series. In that game, he pitched 3 2/3 scoreless innings, gave up three hits and three walks, and struck out four batters on 87 pitches.

Despite not factoring into the decision of the Astros’ 5-4 loss, McCullers showed promising signs.

“It felt great to be back out there. I’ve come a long way, and yeah, I’m proud of myself,” McCullers said post-game. “But there’s more to do, and I know I’ll improve with every outing.”

Matchup History: McCullers vs. the Reds

McCullers has faced the Reds only once in his career, back in 2016. In that outing, he gave up two runs on eight hits over 6 2/3 innings, not factoring into the decision of a 4-2 loss.

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Reds’ Counter: Brady Singer Takes the Mound

Brady Singer (4-2, 3.66 ERA) will start for the Reds on Saturday. He’s looking to bounce back from a second straight loss, most recently giving up four runs over six innings in a loss to Atlanta.

Singer’s career ERA vs. Houston is 4.23 across five starts, indicating that the Astros have found ways to challenge him effectively. Check the Latest Picks from MLB Expert Handicappers

Reds Shake Up Roster Amid Injury Concerns

The Reds made multiple roster moves heading into the weekend:

• Traded for utilityman Connor Joe from the Padres.
• Moved Tyler Callihan to the 60-day injured list due to a broken forearm.
• Jake Fraley (calf soreness) was scratched Friday and may land on the 10-day IL soon.

“It just made sense to be cautious,” said Reds manager Terry Francona. “It’s about getting Jake back healthy and not risking a setback.”

What to Watch For in Saturday’s Game

Can Singer break the slide? His control and command will be tested early.

Can McCullers go deeper? Building stamina is key as he re-integrates into the rotation.

Will the Astros bullpen stay hot? If the game is close late, Houston holds the advantage.

Final Thoughts: McCullers’ Return Adds Firepower to Astros Rotation

With Lance McCullers Jr. gradually regaining form and Houston’s bullpen in elite shape, the Astros are positioning themselves as a serious contender again. Saturday’s game not only gives McCullers a chance to build momentum but also serves as a litmus test for the depth of both teams’ rosters and pitching strategies.