Chicago Cubs vs Miami Marlins Picks and Predictions May 12th 2025

Cubs vs Marlins: Can Either Team Break the Losing Cycle?

As the Chicago Cubs return home for a critical series against the struggling Miami Marlins, both squads are desperate to shake off a rough stretch. Set for Monday night at iconic Wrigley Field, this three-game clash might just be the momentum shift one of these teams needs to reset their season.

Before we dive into pitching matchups, slumps, and silver linings, if you’re looking for expert MLB picks, check out our MLB Pick Page. Let’s dig into the series preview and find out why both teams are under pressure—and which stats may surprise you.

A High-Stakes Homecoming for the Cubs

The Cubs enter this matchup battered after losing back-to-back series for the first time this season. Sunday’s 6-2 defeat to the New York Mets capped a rough road swing. With just three hits in the game—one being Pete Crow-Armstrong’s solo homer—Chicago’s offense sputtered yet again.

Manager Craig Counsell didn’t sugarcoat it:
“Three hits, it’s tough to win games getting three hits,” he said postgame. And he’s right—this lineup has struggled to string together big innings lately.

Chicago’s Pitching Strength Remains Solid

Despite the losses, there’s a bright spot. Starting pitcher Matthew Boyd delivered another gem: six innings, two runs, eight strikeouts, and zero walks. He’s quietly becoming a reliable piece in the rotation.

Boyd’s form gives fans hope, especially when you look at the Cubs’ shaky offensive performances. Can Colin Rea give them the same kind of consistency?

Rea’s Historical Struggles Against Miami

Colin Rea’s record against the Marlins isn’t flattering. He’s 0-2 with an 8.59 ERA in two career appearances. One of those games? A nightmare 2016 outing with San Diego where he was rocked for eight runs in under three innings.

Still, Rea has matured. His current 2.43 ERA suggests this isn’t the same pitcher Miami once punished. Monday’s start is more than just a game—it’s a shot at redemption.

Marlins: Searching for Momentum on the Road

Meanwhile, the Marlins aren’t faring much better. After dropping two of three to the White Sox, they limp into Wrigley having lost 11 of their last 14. Their road woes are especially alarming—only the White Sox and Rockies have fewer away wins.

Sunday’s 4-2 loss to the South Siders featured a rare bright moment: rookie Tim Elko’s first MLB home run, a three-run bomb that proved to be the game-winner.

Alcantara’s Encouraging Return Overshadowed

That homer spoiled an otherwise strong showing from Sandy Alcantara, who’s working his way back from Tommy John surgery. He threw 107 pitches, hit 99.9 mph on the radar gun, and notched eight strikeouts.

One bad pitch—the 1-0 slider Elko crushed—undermined an elite performance. Still, Alcantara’s velocity and stamina were great signs for Marlins fans, especially with trade rumors heating up ahead of the deadline.

For those diving into betting angles, Alcantara’s performance has major implications. Visit our MLB Odds Page for the latest game lines and trends.

Pitching Matchup Breakdown

This series opener features two struggling right-handers—Rea for Chicago and Quantrill for Miami. Let’s look at how their past could shape this clash.

Colin Rea: Reinventing Himself in Chicago

Rea’s 2.43 ERA in 2024 has been a pleasant surprise. His command has improved, and he’s keeping the ball in the park—key factors for success in hitter-friendly Wrigley.

Still, his checkered past against Miami looms large. If he can avoid early damage, the Cubs’ bullpen could take over a close game.

Cal Quantrill: Inconsistent and Exposed

Quantrill hasn’t had much success against the Cubs—or anyone lately. His ERA sits at 7.11 this year, and he’s 1-3 with an 8.31 ERA against Chicago across seven appearances.

The right-hander has bounced between teams in recent years—San Diego, Cleveland, Colorado—and consistency continues to elude him.

Quantrill must rely on inducing ground balls and weak contact. If Chicago’s bats wake up, he could be in for another short outing.

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Players to Watch in the Series

Pete Crow-Armstrong (Cubs)

His solo shot against the Mets might be the confidence booster he needed. With Seiya Suzuki and Cody Bellinger struggling, PCA’s rise could be timely.

Tim Elko (Marlins)

Only his second game, and he already hit a game-winner? Elko’s hot start could earn him more plate appearances. Chicago’s pitchers need to be careful.

Nico Hoerner (Cubs)

Quietly having a solid season. He could be the difference-maker in a close game. Look for him to set the table at the top of the order.

Jazz Chisholm Jr. (Marlins)

When he’s locked in, he’s electric. Chisholm hasn’t looked his best lately, but if he finds his groove, he could steal the show.

Betting Insight: Which Side Has the Edge?

With both teams underperforming, betting this game comes down to trust. The Cubs have been better at home, while the Marlins have struggled mightily on the road.

Considering Rea’s current form and Quantrill’s shaky history, the edge leans toward the Cubs—especially if they can jump on Quantrill early.

Need expert analysis? Dive into our Expert Betting Guide before placing your wager.

Series Outlook: What Each Team Needs

For the Cubs

• Jumpstart the offense: Three hits won’t cut it. They need big games from key bats.
• Solidify bullpen roles: The late-inning meltdown vs. the Mets was costly.
• Keep Boyd’s momentum going: He’s emerging as a top-three starter.

For the Marlins

• Get better on the road: 5-12 isn’t sustainable.
• Build around Alcantara’s return: Even one more elite arm could shift the balance.
• Inject youth: Elko and others might be the spark they need.

Check out all MLB teams’ recent performance on our Team Page to compare where both franchises stand.

FAQs

What time is the Cubs vs Marlins game?

The first pitch is scheduled for Monday night, but check your local listings or the Cubs’ official site for the exact start time.

Who’s favored to win the series?

The Cubs are slight favorites at home, especially with the Marlins’ poor road record.

How has Sandy Alcantara looked since returning?

Despite a loss in his last outing, Alcantara’s velocity and command suggest he’s returning to form.

Can Colin Rea reverse his past struggles vs Miami?

It’s possible—he’s a different pitcher in 2024 and performing at a higher level than ever before.

What’s the most important matchup to watch?

Quantrill vs. the Cubs’ top of the order. If the Cubs start fast, it could be a long night for Miami.

Which site has the best expert picks?

Visit our MLB Pick Page for trusted picks and analysis.

Final Thoughts: A Crucial Series for Two Frustrated Teams

This series might not be a playoff preview, but it’s hugely important for both franchises. The Cubs are trying to hold on to first in the NL Central. The Marlins are just trying to stay afloat.

Will one of these teams find their rhythm? Or will this series only deepen the concerns?

One thing’s for sure—there are stories, strategies, and betting angles galore.