Cleveland Guardians vs Los Angeles Dodgers Picks and Predictions May 26th 2025

Dodgers Turn to Yoshinobu Yamamoto in Clash vs. Guardians

After a hectic weekend in New York, the Los Angeles Dodgers will find a change of pace in Cleveland as they begin a three-game Memorial Day series against the Cleveland Guardians. The Dodgers hand the ball to standout rookie Yoshinobu Yamamoto (5-3, 1.86 ERA), while the Guardians counter with right-hander Gavin Williams (4-2, 3.94 ERA).

Yamamoto has been as dominant as advertised and will be facing Cleveland for the first time in his MLB career. Williams, however, has struggled against Los Angeles, entering the matchup with an 18.00 ERA in two prior starts.

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Dodgers Trying to Bounce Back from Sloppy Series

The Dodgers are coming off a 3-1 loss to the Mets on Sunday, a game marred by four defensive errors. Will Smith committed two of them behind the plate, while Max Muncy and Mookie Betts added one each. Despite the miscues, Shohei Ohtani provided the offense with his 18th home run of the year — a 411-foot shot off fellow Japanese star Kodai Senga.

“He’s having fun and that’s what the game needs, players like that.”
— Carlos Mendoza, Mets Manager

Beyond his bat, Ohtani made headlines with his unofficial pitching debut for the Dodgers, throwing 22 pitches in a simulated setting. His targeted return to the mound is set for mid-July.

“Seeing him on the mound solely as a pitcher — it was different. And certainly exciting for all of us.”
— Dave Roberts, Dodgers Manager

Los Angeles has gone 3-6 since May 16 and faces a tough stretch that includes this road set against Cleveland followed by a World Series rematch with the Yankees in L.A.

Guardians Return Home Riding Momentum

Cleveland is coming off a strong road trip, capped by a 3-1 series win over the first-place Tigers in Detroit. While rain disrupted several games during the nine-game trek, the Guardians stayed focused and resilient.

“We ran into a lot of rain, just a lot of things out of our control, but the boys did not let it affect them.”
— Stephen Vogt, Guardians Manager

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Third baseman Jose Ramirez extended his hitting streak to 18 games — matching the longest of his career — with a seventh-inning single against AL Cy Young winner Tarik Skubal on Sunday. Ramirez continues to be one of the most consistent threats in the American League.

Those tracking MLB Picks and Parlays will have their eyes on this clash between postseason contenders with elite starting pitching and MVP-caliber talent on both sides.

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