Chicago White Sox vs San Francisco Giants Picks and Predictions June 27th 2025

Chicago White Sox vs San Francisco Giants June 27th 2025

The San Francisco Giants will meet the Chicago White Sox at Rate Field in Chicago on Friday, June 27, 2025. The game will start at 7:40 PM and will be broadcast on CHSN. The weather forecast calls for a very hot day with a light breeze and light rain.

The Giants hold a record of 44-37 this season and are managed by Bob Melvin. They are 6 games behind in the NL West. On the other side, the White Sox, led by Will Venable, have a record of 26-55 and are 24 games back in the AL Central. Giants’ starter Landen Roupp has an ERA of 3.67, while White Sox’s Aaron Civale has an ERA of 5.03.

Giants vs White Sox Key Information

• Sport: Baseball
• Teams: San Francisco Giants vs. Chicago White Sox
• Venue: Rate Field in Chicago, IL
• Date: Friday, June 27, 2025
• Betting Odds: Giants MoneyLine -172, White Sox MoneyLine +143

The Giants Can Win If…

The San Francisco Giants are looking to turn things around after their recent loss to the Miami Marlins, where they scored 5 runs on 12 hits. Rafael Devers stood out with a strong performance, going 3 for 4 with a home run and 2 RBIs. Brett Wisely and Willy Adames also contributed with multiple hits, showing the depth in the Giants’ lineup.

Despite recent setbacks, the Giants have a solid chance to win with their pitching strength. They rank 5th in the league with a 3.45 ERA, showing their ability to limit opponents’ scoring. Landen Roupp, their starting pitcher for this game, has a respectable ERA of 3.67, which could give the Giants an edge over the White Sox’s starter, Aaron Civale, who has an ERA of 5.03.

The Giants’ lineup features key players like Rafael Devers and Heliot Ramos, who have been consistent contributors. Devers leads the team with 17 home runs and 63 RBIs, while Ramos adds power with 13 home runs. With their ability to draw walks, ranking 3rd in the league, the Giants can capitalize on scoring opportunities and put pressure on the White Sox’s pitching staff.

The White Sox Can Win If…

The Chicago White Sox are coming off a strong performance against the Arizona Diamondbacks, winning 7-3. Lenyn Sosa led the way with two home runs and four RBIs. Sean Burke pitched five innings, allowing no earned runs, which helped secure the win.

The White Sox have shown they can hit for power, with their recent game featuring three home runs. Their ability to collect extra-base hits ranks them 12th in doubles this season. This power at the plate can be a key factor in their next game.

Aaron Civale will start for the White Sox, aiming to improve his record. The team has a solid defense, with only 14 blown saves this season, ranking 8th. With a balanced lineup and strong pitching, the White Sox have the tools to win their upcoming game against the Giants.

The Lean

The Giants are favored with a moneyline of -172 against the White Sox at +143. The Giants have a stronger pitching staff with a 3.45 ERA, ranked 5th, compared to the White Sox’s 4.19 ERA, ranked 22nd. Given these stats, the recommendation is to pick the Giants to win. The model projects a score of Giants 5, White Sox 3.

The over/under line is set at 8.5 runs. The Giants’ pitching allows fewer runs and has a lower batting average against at .236, ranked 9th. The White Sox’s offense ranks lower in batting average and slugging percentage. With these factors, the recommendation is to take the under. The model projects a total of 8 runs.

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Frustrated Giants Open Road Trip vs. Struggling White Sox

For the San Francisco Giants, a change of scenery can’t come soon enough. After a brutal nine-game homestand, the San Francisco Giants will look to get back on track as they open a 10-game road trip on Friday night in Chicago against the struggling Chicago White Sox.

A Frustrating Homestand

The Giants are coming off a 3-6 homestand that ended in the worst way possible: being swept in three games by the sub-.500 Miami Marlins. To add injury to insult, first baseman Casey Schmitt is day-to-day with a significant bone bruise on his hand after being hit by a pitch.

“I don’t think it’s intentional at all, but it’s definitely not a fun thing to have to go through,” said a frustrated Schmitt, who has been hit by several pitches recently. “It’s annoying.”

Chicago’s Own Struggles

While the Giants are looking for a turnaround, the White Sox are just looking for a win. They have the worst record in the American League and have not won two games in a row since early June. They are also dealing with a key injury, as star outfielder Luis Robert Jr. is day-to-day with hamstring soreness. The matchup features two MLB teams that are desperate for a victory.

A Duel of Opposing Trends

Friday’s pitching matchup features two right-handers with very different recent histories. The Giants will start Landen Roupp (5-5, 3.67 ERA), who is coming off a masterful performance where he tossed six shutout innings against the Red Sox. “When I’m in the zone, everything is good,” Roupp said.

The White Sox will counter with Aaron Civale (1-4, 5.03 ERA). Civale has struggled badly since being acquired by Chicago, losing both of his starts. However, he has a fantastic career record against the Giants (3-1, 2.01 ERA). This “hot hand vs. good history” matchup will be a key focus on the scores and odds board.

Something’s Gotta Give

This series opener is a classic case of two struggling teams looking for a “get-right” game. How teams respond to slumps and injuries is a key topic in our expert betting guide. To see who our experts think will snap out of their funk, check out our daily MLB picks.