Chicago Cubs vs St. Louis Cardinals Picks and Predictions July 5th 2025

Chicago Cubs vs St. Louis Cardinals July 5th 2025

The St. Louis Cardinals travel to Wrigley Field to take on the Chicago Cubs. The game is set for Saturday, July 5, 2025, at 2:20 PM. Fans can catch the action on FDSMW. The weather forecast predicts a warm afternoon with broken clouds and a light breeze.

St. Louis enters the game with a 47-42 record. They are six games behind in the NL Central. The Cardinals’ road record is 21-25. On the other side, the Cubs have a 53-35 record. They have been strong at home with a 29-15 record. The starting pitchers are Matthew Liberatore for the Cardinals and Drew Pomeranz for the Cubs.

Cardinals vs Cubs Key Information

• Sport: Baseball
• Teams: St. Louis Cardinals vs. Chicago Cubs
• Venue: Wrigley Field in Chicago, IL
• Date: Saturday, July 5, 2025
• Betting Odds: Cardinals Moneyline +102, Cubs Moneyline -121, Cardinals Runline +1.5 (-183), Cubs Runline -1.5 (+154), Total Over 10.5 (-116), Total Under 10.5 (-104)

The Cardinals Can Win If…

The St. Louis Cardinals are looking to bounce back after a tough loss to the Chicago Cubs, 11-3. In that game, Brendan Donovan hit a home run, and Lars Nootbaar added a single and an RBI. Despite the loss, the Cardinals have shown they can hit for power, with Donovan and Nootbaar leading the way.

The Cardinals have some strong stats that suggest they can win. They rank 7th in batting average at .251 and 3rd in doubles with 152. Their starting pitcher, Matthew Liberatore, has a solid ERA of 3.70, which could help keep the Cubs’ offense in check.

St. Louis has talented players like Willson Contreras, who leads the team with 11 home runs and 51 RBIs. Brendan Donovan is also key, with a .293 batting average. With these players in form, the Cardinals have a good chance to win the next game.

The Cubs Can Win If…

The Chicago Cubs are coming off a strong win against the St. Louis Cardinals, finishing 11-3. Michael Busch and Pete Crow-Armstrong were perfect at the plate, each going 4-for-4. Colin Rea pitched well, allowing only one hit in over six innings.

Offensively, the Cubs rank high in several categories. They are third in slugging percentage at .449 and have hit 133 home runs, also ranking third. Their ability to hit for power can make a big difference in the game.

Drew Pomeranz will start for the Cubs, and he has been effective with a 0.00 ERA. The Cubs’ pitching staff has been solid, with 34 quality starts this season. This combination of strong hitting and pitching gives them a good chance to win.

The Lean

The Cubs are favored on the moneyline at -121, and they have a better hitting lineup. They rank 3rd in slugging percentage and home runs, which gives them an edge. My model projects the Cubs to win with a score of 6-5. So, the recommendation is to pick the Cubs to win straight up.

The total for the game is set at 10.5 runs. Both teams have strong hitting stats, and their pitching ranks are in the middle. My model projects a total score of 11 runs. Therefore, the recommendation is to bet on the over 10.5 runs.

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High-scoring Cubs aim to tee off again vs. rival Cards

After unleashing eight homers in Friday’s record-setting 11-3 win, the Cubs will look to sustain their power surge in Saturday’s middle game against the Cardinals at Wrigley Field. Chicago’s lineup has proven formidable all season—so dominant that observers and bettors alike are taking notice in their latest MLB previews.

Power Display Continues

Chicago center fielder Pete Crow-Armstrong called Friday’s outing “the best offense I’ve ever been a part of,” and his praise is backed by results. Crow-Armstrong went 4-for-4 with two homers, boosting his OPS to .868, while Michael Busch became the first Cub in franchise history to hit three homers in a single game. Such performances have caught the eye of many looking for reliable MLB picks.

Season-Long Offensive Firepower

Through early July, the Cubs have scored 475 runs—second most in the majors—and are riding a seven-win surge over their last nine outings. That kind of consistency makes Chicago a frequent subject of the MLB expert betting guide, as handicappers evaluate whether this lineup can maintain its torrid pace deep into the second half.

Bullpen Game to Kick Off

Instead of a traditional starter, Chicago will open with veteran Drew Pomeranz in a bullpen game. Pomeranz boasts a 0.00 ERA over 23⅓ relief innings this season and held St. Louis scoreless in two recent outings. Fans looking to back Chicago’s arms can secure their selections now via buy picks.

Cardinals Look to Regroup

St. Louis has dropped four straight and trails the Cubs by 6½ games in the NL Central, but lefty Matthew Liberatore offers hope. Liberatore has won his last three starts, including a 7-0 shutout of Cleveland, and he blanked the Cubs over seven innings in late June. Bettors tracking top performers can see current standings on the handicappers leaderboard.

What to Watch and Betting Angles

Saturday presents a clash of contrasting approaches: Chicago’s slugging lineup against the Cardinals’ bid to rediscover their offense under a hot-handed starter. Early bets on first-five-inning runs may favor the Cubs, while late-game options could lean toward St. Louis if Liberatore keeps Chicago off the board. Either way, this series remains must-see baseball at the Friendly Confines.