Arizona Diamondbacks vs Cleveland Guardians Picks and Predictions August 20th 2025

Arizona Diamondbacks vs Cleveland Guardians August 20th 2025

The Cleveland Guardians will visit the Arizona Diamondbacks at Chase Field on Wednesday, August 20, 2025. The game is set for an afternoon start at 3:40 PM. Fans can catch the action on the ARID channel.

The Guardians, led by manager Stephen Vogt, hold a record of 64-60 and are ranked second in the AL Central. They recently snapped a losing streak with a win. The Diamondbacks, managed by Torey Lovullo, have a record of 60-66 and are fourth in the NL West. They are looking to end a four-game losing streak.

Guardians vs Diamondbacks Key Information

• Sport: Baseball
• Teams: Cleveland Guardians vs. Arizona Diamondbacks
• Venue: Chase Field in Phoenix, AZ
• Date: Wednesday, August 20, 2025
• Betting Odds: Guardians Moneyline +109, Diamondbacks Moneyline -127, Guardians Runline +1.5 (-184), Diamondbacks Runline -1.5 (+153), Total Over 9.0 (-109), Total Under 9.0 (-111)

The Guardians Can Win If…

The Cleveland Guardians recently won against the Arizona Diamondbacks with a score of 3-1. Gavin Williams was strong on the mound, pitching over five innings without giving up a run. C.J. Kayfus and Brayan Rocchio each hit a home run, contributing to the team’s victory.

The Guardians have shown they can win with their pitching. Their team ERA is 3.86, ranking 13th in the league. They also limit opponent batting averages to .241, which ranks them 11th in this category.

José Ramírez is a key player for the Guardians. He has a batting average of .290 and has hit 25 home runs this season. With players like Ramírez, the Guardians have the potential to score runs and secure another win.

The Diamondbacks Can Win If…

The Arizona Diamondbacks are looking to bounce back after a 3-1 loss to the Cleveland Guardians. Zac Gallen pitched six innings, allowing three runs on five hits. Geraldo Perdomo was a standout with two hits and one RBI, showing his ability to contribute offensively.

Arizona’s hitting stats are strong, with a team batting average of .250, ranking 7th in the league. Their slugging percentage of .439 is 3rd, showing their power at the plate. With 176 home runs, they are 4th in the league, which could play a key role in their next game.

Brandon Pfaadt will start on the mound for the Diamondbacks. His record of 12-8 shows he can deliver wins. Arizona’s lineup includes Ketel Marte and Corbin Carroll, who have combined for 50 home runs this season, making them a threat to any opposing pitcher.

The Lean

The Diamondbacks are favored on the moneyline at -127, while the Guardians are at +109. The Diamondbacks have a better batting average and on-base percentage, ranking 7th and 4th, respectively. My model projects a score of Diamondbacks 5, Guardians 4. Given these factors, the pick is for the Diamondbacks to win straight up.

The total for the game is set at 9.0, with the over at -109 and the under at -111. The Diamondbacks’ pitching has an ERA of 4.57, ranked 25th, which suggests runs could be scored. My model projects a total score of 9 runs. Therefore, the recommendation is to take the over on the total.

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Messick’s Big Moment: Guardians Rely on Rookie vs D-backs

The Cleveland Guardians are turning to youth in a pivotal moment of their season. As the team fights to stay in the American League Wild Card chase, rookie Parker Messick will make his major league debut on Wednesday afternoon against the Arizona Diamondbacks in the final game of a hard-fought three-game series in Phoenix.

Welcome to the Show, Parker Messick

Messick, just 24 years old, is more than just a fill-in starter. He’s been climbing the ladder with purpose since being drafted in the second round back in 2022. His arsenal, highlighted by a filthy low-80s changeup, has been fooling hitters in Triple-A all year.

In his last five outings with Triple-A Columbus, Messick posted an 0.88 WHIP across 30 2/3 innings. With Cleveland just three games out of the AL Wild Card race, the pressure’s on—but so is the opportunity.

Diamondbacks’ Lineup Stays Hot

Tuesday night’s 6-5 D-backs win wasn’t just a comeback—it showcased why Arizona’s new top-three lineup might be their best yet. Geraldo Perdomo, Ketel Marte, and Corbin Carroll are leading off in style.

Together, they’re batting .323 with 6 doubles, 3 triples, and 4 home runs over their last eight games. Carroll, in particular, is rewriting the record books.

On Tuesday, the rookie sensation logged his fourth two-triple game of the year, pushing his total to a league-leading 16 triples. Only six players have accomplished that many two-triple games in a season since 1901—the last being Carl Crawford in 2004.

Arizona manager Torey Lovullo isn’t changing things anytime soon. “Corbin is full of slug,” he said. “With ‘Gerry’ getting on base and Marte driving the ball, this top of the order gives us a real spark.”

Pfaadt vs Messick: Experience Meets Potential

Cleveland’s rookie will be up against Brandon Pfaadt, who leads Arizona in wins but also ranks near the bottom in ERA among NL starters.

Pfaadt allowed four earned runs over six innings in a loss to Colorado last week, ending his short two-game win streak. He has allowed the fourth-most hits in the league (151), but his 12 wins tie him for third-most in the National League.

He faced the Guardians once before—on August 7—and came away with a win after tossing 6 1/3 innings of two-run ball.