San Diego Padres vs San Francisco Giants Picks and Predictions August 20th 2025

San Diego Padres vs San Francisco Giants August 20th 2025

The San Francisco Giants will visit the San Diego Padres at PETCO Park for a night game on Wednesday, August 20, 2025. The Giants have a 61-64 record and are ranked third in the NL West. They have won their last two games but have struggled in their last ten with a 3-7 record.

The Padres hold a 69-56 record and are second in the NL West. They have lost their last four games and are 5-5 in their last ten. The game will feature starting pitchers Landen Roupp for the Giants and JP Sears for the Padres. The weather is expected to be warm with scattered clouds and a light breeze. The game will be televised on MLBN.

Want betting confidence tonight? Get the latest predictions in our MLB picks and full-game breakdowns from the expert betting guide.

Giants vs Padres Key Information

• Sport: Baseball
• Teams: San Francisco Giants vs. San Diego Padres
• Venue: PETCO Park in San Diego, CA
• Date: Wednesday, August 20, 2025
• Betting Odds: Giants Moneyline +132, Padres Moneyline -157, Giants Runline +1.5 (-164), Padres Runline -1.5 (+136), Total Over 8.0 (-114), Total Under 8.0 (-107)

The Giants Can Win If…

The San Francisco Giants are coming off a win against the San Diego Padres, finishing 4-3. Robbie Ray pitched well, allowing no earned runs over 6 2/3 innings. Key hitters like Wilmer Flores, Rafael Devers, and Heliot Ramos each hit a home run, contributing to the victory.

The Giants’ pitching staff has been strong this season, with a team ERA of 3.69, ranking 5th in the league. They have given up the fewest home runs, with only 108 allowed. This solid pitching foundation gives them a good chance to control the game against the Padres.

Rafael Devers leads the team with 24 home runs and 82 RBIs, making him a key player to watch. The lineup also features Heliot Ramos, who holds a .267 batting average and 15 home runs. With power hitters and strong pitching, the Giants have the tools to secure another win.

The Padres Can Win If…

The San Diego Padres are looking to bounce back after a close 4-3 loss to the San Francisco Giants. In that game, Ryan O’Hearn hit a home run and drove in two runs. Despite the loss, the Padres showed they can compete with strong teams.

The Padres have a team batting average of .251, ranking sixth in the league. Manny Machado leads the team with a .290 average and 20 home runs. With players like Fernando Tatis Jr. and Xander Bogaerts, the Padres have a lineup capable of producing runs.

On the mound, the Padres will start JP Sears, who has a 5.12 ERA. The Padres’ pitching staff holds a 3.59 ERA, placing them fourth in the league. If Sears can deliver a solid outing, the Padres have a good chance to secure a win against the Giants.

The Lean

The Padres are favored with a moneyline of -157, while the Giants are at +132. The Padres have a better team batting average and on-base percentage. Their pitching also ranks higher in earned run average and batting average against. My model projects the Padres to win 5-3. Based on these factors, I recommend picking the Padres to win straight up.

The consensus total for the game is set at 8.0 runs. The Padres’ pitching has a strong earned run average and limits home runs. The Giants’ offense ranks low in home runs and slugging percentage. My model projects a total score of 8 runs. I recommend taking the under at 8.0 (-107) for this game.

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Sears Seeks Redemption: Padres Face Giants in Crucial Clash

If you’re weighing this West Coast rivalry on your ticket, check today’s MLB picks and the expert betting guide for key matchup edges.

JP Sears is back on the bump for the San Diego Padres Wednesday night in a bounce-back opportunity against the San Francisco Giants. The lefty, part of the blockbuster trade with Oakland at the deadline, didn’t impress in his debut earlier this month—but there’s optimism in the dugout.

Why Sears Could Shine Tonight

Sears was roughed up by the Diamondbacks on August 4, surrendering five runs over five innings. But after a solid Triple-A tune-up—two earned runs on six hits over five frames—he’s getting another shot.

His track record against the Giants is promising:

Notably, he shut them out for six innings in an 11–2 win on July 4. Plus, pitching at Petco Park—one of the league’s toughest parks for hitters—should work in his favor.

Padres Riding Momentum, Despite Injuries

After dropping four straight, San Diego got back on track Tuesday night with a 5–1 win. Manny Machado and Ryan O’Hearn both notched two hits and an RBI.

They did it without Jackson Merrill and Jake Cronenworth, both sidelined due to injury.

“We needed that,” O’Hearn said after the win. “It was huge.”

The Padres now sit two games behind the Los Angeles Dodgers in the NL West but are currently holding a Wild Card spot.

Giants Aim to Clean It Up

Meanwhile, the Giants are trying to clean up a messy stretch. Tuesday’s loss marked their third straight game with two errors, including costly ones by Christian Koss and Casey Schmitt.

Starter Landen Roupp takes the mound Wednesday. He gave up five runs over three innings against Tampa Bay last week but holds a sneaky-good track record vs San Diego.