Chicago Cubs vs Milwaukee Brewers Picks and Predictions August 21st 2025

Chicago Cubs vs Milwaukee Brewers August 21st 2025

The Milwaukee Brewers will take on the Chicago Cubs at Wrigley Field. The game is set for Thursday, August 21, 2025, at 2:20 PM. Fans can catch the action on FDSWI.

The Brewers hold a record of 79-48, leading the NL Central. They aim to break a three-game losing streak. The Cubs, with a record of 73-54, are second in the division and have won their last three games.

Brewers vs Cubs Key Information

• Sport: Baseball
• Teams: Milwaukee Brewers vs. Chicago Cubs
• Venue: Wrigley Field in Chicago, IL
• Date: Thursday, August 21, 2025
• Betting Odds: Brewers Moneyline +116, Cubs Moneyline -137, Total Over 7.0 (-109), Total Under 7.0 (-112)

The Brewers Can Win If…

The Milwaukee Brewers recently played against the Chicago Cubs, losing 4-3. Brice Turang had a strong performance, going 3-for-3 with a run and an RBI. Jacob Misiorowski pitched four innings, allowing only one hit but giving up three earned runs.

The Brewers have solid stats that can lead them to victory. They rank second in the league in both batting average (.258) and on-base percentage (.331). Their pitching staff holds a 3.58 ERA, placing them fourth, and they have a batting average against of .229, ranking third.

Quinn Priester will start for the Brewers, with an 11-2 record and a 3.48 ERA. The lineup includes Christian Yelich, who has 26 home runs and 87 RBIs this season. Brice Turang, with a .284 average, is another key player to watch.

The Cubs Can Win If…

The Chicago Cubs are coming off a close 4-3 win against the Milwaukee Brewers. Colin Rea pitched 5 2/3 innings, allowing only 3 hits and 2 earned runs. Michael Busch and Matt Shaw were key players, driving in runs to secure the victory.

The Cubs have shown strong hitting stats this season, with a team slugging percentage ranked 5th in the league. They have hit 173 home runs, placing them 7th overall. Their ability to get extra-base hits gives them an edge in scoring opportunities.

Shota Imanaga will start for the Cubs with an impressive ERA of 3.06 and a WHIP of 0.95. His ability to limit base runners can keep the Brewers’ offense in check. With players like Seiya Suzuki and Michael Busch leading the lineup, the Cubs have the potential to continue their winning streak.

The Lean

The Cubs are favored with a moneyline of -137. The Brewers have a moneyline of +116. Given the Cubs’ strong batting average and on-base percentage, they are likely to win. My model projects a score of Cubs 4, Brewers 3. The Cubs’ pitching ranks higher, which supports this pick.

The total line is set at 7.0 with the over at -109 and the under at -112. My model projects a total score of 7 runs. This aligns with the current line, but considering the Cubs’ pitching strength, the under is a safer pick. The Cubs’ ability to limit runs makes the under a solid choice.

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Brewers Look to Halt Slide vs Cubs in Series Finale

The Milwaukee Brewers are looking to avoid their first three-game losing streak since early May as they take on the Chicago Cubs Thursday night at Wrigley Field. The Cubs have taken three of the first four games in this rare five-game set and have cut Milwaukee’s NL Central lead to six games.

Before betting the finale, check the sharpest angles in today’s MLB picks and get insights from the full expert betting guide.

Cubs Ride Momentum After Electric Win

Chicago edged Milwaukee 4–3 Wednesday behind clutch defense and a solo homer from rookie Matt Shaw. Closer Daniel Palencia stranded the bases loaded in the ninth to notch his 18th save.

Shaw called the energy “unbelievable” as Wrigley roared to life. Meanwhile, manager Craig Counsell confirmed outfielder Kyle Tucker has been dealing with a hairline fracture in his hand since June—possibly contributing to a post-All-Star Break slump.

Brewers Try to Regroup

Veteran Christian Yelich isn’t worried. “This team is fine,” he said. “We’re not happy we lost, but we competed.”

Quinn Priester (11-2, 3.48 ERA) will try to stop the bleeding. The righty has been key to Milwaukee’s rise since joining from Boston in April.

He was shelled by Chicago in May but rebounded in July with a strong outing. Priester has been especially tough on the road and keeps the ball in the park—just 17 homers allowed in 124 innings.

Imanaga Continues Strong August

Lefty Shota Imanaga (8-5, 3.06 ERA) gets the call for the Cubs. He’s been excellent this month, posting a 2.25 ERA across three starts with 22 Ks and just two walks.

Imanaga has struggled in his career vs Milwaukee (7.20 ERA), but he beat them last month and looks healthy after missing time with a hamstring injury.