Virginia Tech Hokies vs Vanderbilt Commodores Picks and Predictions September 6th 2025

Virginia Tech vs Vanderbilt Picks and Predictions

Following a disappointing opening loss to South Carolina, the Virginia Tech Hokies are seeking revenge and redemption as they host the Vanderbilt Commodores for the first time since 1989. After a team-led meeting earlier this week, the Hokies hope to reestablish their footing and avoid their first 0-2 start since 2010.

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Meanwhile, Vanderbilt heads to Blacksburg brimming with confidence after a dominant win over Charleston Southern, led by quarterback Diego Pavia’s sharp debut.

This Saturday’s showdown isn’t just a rematch from last season—it’s a measuring stick for two teams aiming to prove they belong in the early-season conversation.

Review of Recent Performances

Virginia Tech started slow, struggling offensively in a 24-11 loss to South Carolina. Despite holding the ball for nearly 34 minutes and outgaining the Gamecocks, costly mistakes like two interceptions from quarterback Kyron Drones and two explosive plays allowed in the fourth quarter sealed their fate.

Vanderbilt, on the other hand, looked poised and precise. In their 45-3 rout of Charleston Southern, Diego Pavia passed for 275 yards and three touchdowns, showing improved command and accuracy. It was a statement performance that raises expectations heading into Week 2.

To get real-time odds for this matchup, visit the College Football Picks and NCAAF Odds pages.

Side-by-Side Comparison

Key Players to Watch

Drones was efficient in stretches but couldn’t finish drives. The Hokies need more consistency from him, especially in the red zone. The dual-threat quarterback completed 22 of 33 passes last time against Vanderbilt but must avoid costly turnovers.

Vanderbilt: Diego Pavia

In only his second start, Pavia is already being talked about as a breakout player. He showed composure in the pocket and chemistry with receivers like Kayleb Barnett and Junior Sherrill. Expect him to test Virginia Tech’s secondary early and often.

Storylines to Follow

Virginia Tech is motivated by last year’s 34-27 overtime loss to Vanderbilt and their sluggish start to this season. Linebacker Jaden Keller emphasized the urgency in this week’s team meeting, citing how close the team was to winning. This game presents a chance to reset the tone.

Vanderbilt, meanwhile, sees this as a statement opportunity. Head coach Clark Lea knows the stakes are rising, and he’s familiar with the challenges of Lane Stadium. A win here would not only prove the Commodores are ahead of schedule, but it would also boost their national credibility.

Betting Outlook and Predictions

This game is closer than most early season matchups. While Vanderbilt has more offensive momentum, Virginia Tech has home-field advantage and a defense capable of making key stops.

Picks Table

If you’re planning to wager, be sure to review the Expert NFL Betting Guide—it includes college football betting insights that can help shape your strategy.

And for team previews, historical matchups, and roster analysis, explore the NCAAF Teams Hub.