Los Angeles Angels vs Oakland Athletics Picks and Predictions September 5th 2025

Angels vs. Athletics Prediction: Soriano Looks to Keep Oakland Quiet

The Los Angeles Angels return home Friday night to open a three-game set against the Oakland Athletics. First pitch from Angel Stadium in Anaheim, CA, is scheduled for 9:38 PM ET.

Los Angeles (66-74) holds a slim 2.5-game edge over Oakland (64-77) to stay out of the AL West basement. The Angels have dominated the head-to-head matchup so far, leading the season series 8-2, including a three-game sweep at home in June.

Matchup Overview

• Venue: Angel Stadium, Anaheim, CA
• Date: Friday, Sept. 5, 2025 – 9:38 PM ET
• Probable Starters: Mason Barnett (OAK) vs. José Soriano (LAA)
• Betting Odds: Athletics ML +155, Angels ML -182, Runline OAK +1.5 (-125) / LAA -1.5 (+104), Total 8.5 (O -108 / U -112)

The Athletics Can Win If…

Rookie right-hander Mason Barnett makes his second career start after debuting against Texas, where he allowed five runs in four-plus innings. The former second-round pick flashed velocity up to 97 mph, but execution and command will be tested against an Angels lineup that’s had his number at every level.

Offensively, Oakland will need to put pressure on Soriano early. The A’s lineup has struggled in road games, but with hitters like Brent Rooker and Zack Gelof, they’ll look to take advantage if Soriano falls behind in counts.

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The Angels Can Win If…

José Soriano has found his rhythm. The right-hander hasn’t allowed a run across his last two starts (12 2/3 IP), dominating both Texas and Houston with 14 strikeouts. Against the A’s, however, he owns a rough 7.09 ERA in seven career outings, making this a key test of his progress.

The Angels’ lineup has shown balance, with Taylor Ward and Logan O’Hoppe providing steady power support. If Soriano can replicate his recent efficiency, Los Angeles is well-positioned to widen the gap in the standings.

Stay updated on movement for this divisional clash at MLB Scores and Odds.

Handicapper Spotlight

This AL West matchup may not feature playoff contenders, but it’s still a betting opportunity. Our MLB handicappers have been rolling with consistent profits in September. Check the leaderboard below to see who’s hot and where the smart money is landing on Angels vs. Athletics.

Betting Outlook

The Angels are -182 favorites, and Soriano’s recent form justifies the price. My model calls for a 5-3 Angels win, with Soriano limiting Oakland’s offense enough to offset Barnett’s inexperience on the road.

The total sits at 8.5, and the lean is on the under (-112) given Soriano’s hot streak and Oakland’s offensive inconsistencies.

If you’re locking in plays, the MLB Expert Betting Guide provides deeper insights into betting divisional matchups.