Baltimore Orioles vs Pittsburgh Pirates Picks and Predictions September 10th 2025

Baltimore Orioles vs Pittsburgh Pirates September 10th 2025

The Pittsburgh Pirates will take on the Baltimore Orioles at Oriole Park at Camden Yards. The Pirates come into this game with a 64-81 record and are currently ranked fifth in the NL Central. They are looking to break a four-game losing streak. Paul Skenes will start for the Pirates, bringing an ERA of 1.98 and a WHIP of 0.94.

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The Baltimore Orioles hold a 67-77 record and also sit fifth in their division, the AL East. They have won seven of their last ten games and are on a one-game winning streak. Tyler Wells will be on the mound for the Orioles, boasting an ERA of 3.60 and a WHIP of 1.00. The weather forecast predicts light rain, with a mild breeze blowing out. The game will be broadcast on MASN at 6:35 PM.

Pirates vs Orioles Key Information

• Sport: Baseball
• Teams: Pittsburgh Pirates vs. Baltimore Orioles
• Venue: Oriole Park at Camden Yards in Baltimore, MD
• Date: Wednesday, September 10, 2025
• Betting Odds: Pirates Moneyline -146, Orioles Moneyline +124, Pirates Runline -1.5 (+123), Orioles Runline +1.5 (-147), Total Over 7.5 (-103), Total Under 7.5 (-117)

The Pirates Can Win If They Ride Momentum and Skenes’ Arm

The Pittsburgh Pirates are sending ace Paul Skenes to the mound, and there’s no denying his impact. He enters with a 1.98 ERA and is one of the hottest pitchers in the league. With 195 strikeouts and a 6-1 post-All-Star Break record, he gives Pittsburgh a massive edge.

Offensively, Pittsburgh’s bats have shown signs of life, especially from veterans like Andrew McCutchen and Bryan Reynolds. With a top-10 walk rate and a pitching staff that limits opponent batting average to .237 (7th in MLB), they’re built to capitalize on mistakes and stay in close games.

The Orioles Can Win If the Bats Stay Clutch

The Baltimore Orioles continue to thrive in late-game moments. Rookie Samuel Basallo has delivered two walk-offs in the last three games, including Tuesday night’s 11th-inning game-winner. With six wins in their last seven, Baltimore’s young core—Jackson Holliday, Gunnar Henderson, and Jeremiah Jackson—is showing grit.

Tyler Wells (1-0, 3.60 ERA) gives the Orioles a fighting chance. If he can deliver five solid innings and the offense continues to capitalize on high-leverage opportunities, the Orioles could surprise as underdogs again.

The Lean

• Moneyline Pick: Pirates (-146)
• Projected Score: Pirates 5, Orioles 3

Recommended Plays:

• Pirates to win straight up
• Over 7.5 total runs (Both pitchers are vulnerable to big innings)

For more MLB picks and predictions, check out our full breakdowns daily.

Why This Matchup Matters

Paul Skenes is just five strikeouts away from 200 on the season. He’s been Pittsburgh’s most consistent arm all year, logging a 1.90 ERA since the break and holding batters to minimal contact. His first career start against Baltimore puts him in the spotlight once more.

Orioles’ Grit Has Paid Off

Even with a depleted roster and key injuries, the Orioles have gone 6-1 in their last seven games. Interim manager Tony Mansolino has gotten the most out of call-ups, and Baltimore’s ability to perform in clutch moments is keeping them alive.

Historical Trends Favor Baltimore at Home

Baltimore is 14-3 in regular-season home games against the Pirates. However, with Paul Skenes on the hill, that trend is being tested against one of the league’s elite arms.

For insights on current odds, visit our MLB scores and odds page.

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