Cleveland Guardians vs Chicago White Sox Picks and Predictions September 12th 2025

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White Sox look to continue winning ways vs. Guardians

Chicago White Sox (57-90) may be buried in the AL Central standings, but they’re suddenly playing some of the best baseball in MLB. Winners of nine of their last 11, the Sox open a three-game series at Progressive Field against the Cleveland Guardians (75-71) on Friday night.

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The White Sox just handled the Rays at home, while Cleveland comes off a comeback win over Kansas City to keep slim postseason hopes alive. Checking the latest MLB game results, both teams are proving capable of turning games late, which sets the stage for a tight opener.


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Chicago White Sox Can Win If…

  • Martín Pérez holds up. While his career ERA vs. Cleveland is rough (7.39), his current 3.15 ERA suggests he’s capable of delivering a quality start.
  • Young hitters stay hot. Colson Montgomery, Kyle Teel, and Chase Meidroth have sparked the Sox lineup with clutch hits. If they keep producing, Chicago’s recent surge could continue.
  • They ride momentum. Playing loose with nothing to lose has freed up this team, making them a dangerous spoiler.

“It’s a testament to these guys and the work they’ve done, continuing to go out there and fight every day,” said manager Will Venable.

Cleveland Guardians Can Win If…

  • Tanner Bibee finds consistency. Though 3-0 vs. Chicago in his career, his 5.73 ERA vs. the Sox shows he’s been hittable. A clean start is crucial to avoid giving away early runs.
  • José Ramírez leads the charge. With 28 HR and a steady bat, he remains the key to Cleveland’s offensive identity.
  • Their depth steps up. C.J. Kayfus’ clutch two-run blast Thursday showed that role players can change games. If more unexpected heroes emerge, the Guardians will be tough to beat.

“That was truly, probably the best feeling I’ve ever had in my life right there,” Kayfus said of his go-ahead homer.


Key MLB Betting Trends

CategoryWhite SoxGuardians
Record57-9075-71
Last 10 Games8-2, hottest stretch of yr7-3, steady at home
Runs Per GameBelow avg but streakingMiddle of AL pack
ERA / Opp RunsPérez solid, staff shakyTop-10 ERA, strong staff
Home/Away RecordWeak overall, scrappy nowSolid home field edge

The Leans

Main Pick: Guardians Moneyline (-172)
Projected Score: Guardians 5, White Sox 3

  • Runline Angle: Guardians -1.5 (+128) → Chicago has been hot, but Bibee’s past wins vs. them suggest Cleveland can stretch margin late.
  • Total Runs Angle: Over 7.5 (-115) → Both teams are riding momentum offensively, and with Pérez’s Cleveland struggles plus Bibee’s inconsistency, runs should come.

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