St. Louis Cardinals vs Cincinnati Reds Picks and Predictions September 15th 2025

St. Louis Cardinals vs Cincinnati Reds September 15th 2025

The Cincinnati Reds will play against the St. Louis Cardinals at Busch Stadium on Monday, September 15, 2025. The Reds have a record of 74-75 and are third in the NL Central. They are looking to break a three-game losing streak. The Cardinals have a record of 73-77 and are fourth in the division, coming off a win in their last game.

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The game will start at 7:45 PM and will be broadcast on FDSMW. Weather forecasts predict a very hot day with a light breeze and overcast clouds. Zack Littell will start for the Reds, with an ERA of 3.78. Matthew Liberatore will pitch for the Cardinals, holding an ERA of 4.35.

Reds vs Cardinals Key Information

• Sport: Baseball
• Teams: Cincinnati Reds vs. St. Louis Cardinals
• Venue: Busch Stadium in St. Louis, MO
• Date: Monday, September 15, 2025
• Betting Odds: Reds Moneyline +105, Cardinals Moneyline -124, Reds Runline +1.5 (-196), Cardinals Runline -1.5 (+163), Total Over 8.5 (-108), Total Under 8.5 (-113)

The Reds Can Win If…

The Cincinnati Reds enter this series after a frustrating sweep by the Athletics. Now sitting at 74-75 and 2.5 games behind the Mets for the final NL Wild Card, Cincinnati must capitalize on this series in St. Louis.

Zack Littell (9-8, 3.78 ERA) starts for the Reds and is coming off a strong outing against San Diego, allowing just two runs over six innings. He retired 11 straight batters in that game, leaning on his mix of fastballs, splitters, and cutter-like sliders.

While Littell is 0-2 with a 6.04 ERA in 22.1 innings vs. the Cardinals, his recent form provides optimism. If Littell limits damage and the offense wakes up, Cincinnati can turn its postseason hopes around.

The Cardinals Can Win If…

The St. Louis Cardinals snapped a five-game losing streak with a 3-2 win over the Brewers and sit at 73-77, four games back in the Wild Card race.

Matthew Liberatore (7-12, 4.35 ERA) will get the start, looking to rebound from a five-run outing vs. Seattle. He has struggled against the Reds this season with a 5.63 ERA over two starts, but his career line against Cincinnati (3.45 ERA in 15.2 IP) is more encouraging.

With Brendan Donovan back and Nolan Arenado expected to return, the Cardinals’ lineup could be at near full strength—key for their playoff push.

The Lean

The Reds have lost momentum but are desperate to get back in the hunt. Littell’s recent starts give them a slight edge over the inconsistent Liberatore. However, both bullpens have struggled and both teams are battered.

My projection has the Reds winning 5–4, and the moneyline underdog play on Cincinnati offers good value in a tight matchup.

The total is set at 9.5 runs, and with both starters carrying ERAs over 4.00 and recent trends showing runs scored late, I lean over 9.5 as the better option.

Want more expert betting insight? Check the latest MLB odds and scores or grab today’s best MLB picks before first pitch.

Pitching Comparison

Littell is in better form but has struggled historically against the Cardinals. Liberatore hasn’t been consistent, allowing 10 hits in 8 innings to the Reds this year.

Reds vs Cardinals – Team Stats

Both teams rank middle-of-the-pack in key offensive and pitching metrics. This matchup will likely come down to execution in late innings.

Playoff Implications

Cincinnati can’t afford more losses if it wants to catch the Mets in the Wild Card race. St. Louis has a tougher hill to climb but is hoping reinforcements like Arenado and Donovan help fuel a final-week surge.

The expert betting guide breaks down trends like team momentum, player injury status, and matchup history—don’t miss it ahead of first pitch.