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St. Louis Cardinals vs Cincinnati Reds September 17th 2025
The Cincinnati Reds take on the St. Louis Cardinals at Busch Stadium on Wednesday, September 17, 2025. The Reds hold a record of 75-76 and are third in the NL Central. They are coming off a loss and have gone 5-5 in their last ten games. The Cardinals are just behind with a 74-78 record, sitting fourth in the division. They won their last game and are 4-6 over their last ten.
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This afternoon game will feature Brady Singer on the mound for the Reds. He has a 13-10 record with a 3.94 ERA. The Cardinals will counter with Andre Pallante, who has a 6-14 record and a 5.34 ERA. The weather forecast calls for a mild day with broken clouds and a calm wind blowing out. Fans can catch the game on FDSMW.
Reds vs Cardinals Key Information
- Sport: Baseball
- Teams: Cincinnati Reds vs. St. Louis Cardinals
- Venue: Busch Stadium in St. Louis, MO
- Date: Wednesday, September 17, 2025
- Betting Odds:
- Reds Moneyline: -112
- Cardinals Moneyline: -106
- Reds Runline: -1.5 (+147)
- Cardinals Runline: +1.5 (-175)
- Total Over: 8.5 (-111)
- Total Under: 8.5 (-109)
The Cincinnati Reds Can Win If…
The Cincinnati Reds have dropped four of their past five, but their 11-6 win earlier in the series against St. Louis showed their offensive upside. Sal Stewart powered the lineup with a home run and three hits, while the team collected 13 overall. When this group strings together hits, they are difficult to slow down.
Cincinnati carries a .245 batting average, ranking 9th in MLB, and a .316 on-base percentage. Their pitching staff owns a 3.99 ERA while holding opponents to a .237 average, seventh-best in the league. That balanced approach means they can win on both ends of the diamond.
Brady Singer will take the mound, bringing a 3.94 ERA. He has been effective in September with a 2.25 ERA and success against the Cardinals this season, where he’s allowed just a 2.50 ERA in three starts. If Singer continues that form and the Reds’ bats take advantage of Andre Pallante’s inconsistency, Cincinnati has the edge.
The St. Louis Cardinals Can Win If…
The St. Louis Cardinals earned a 3-0 shutout victory in the last game, behind Michael McGreevy’s seven innings and Thomas Saggese’s two-run homer. With Masyn Winn sidelined for the season, Saggese has seized the opportunity, hitting .294 in September and giving the Cardinals an energy boost.
St. Louis matches Cincinnati’s batting average at .245 and sits 12th in MLB with 242 doubles. Alec Burleson and Brendan Donovan both provide steady production with .283 averages and have the ability to keep rallies alive. With timely hitting and defensive execution, the Cardinals can stay competitive.
Andre Pallante brings a 5.34 ERA into this game and has been on a rough stretch, posting a 7.11 ERA across his last eight starts. However, he has enjoyed past success against the Reds, carrying a 2.08 ERA in 18 career appearances. If Pallante can tap into that history and limit damage, the Cardinals’ offense will have opportunities to grind out a win.
The Lean
According to the latest MLB odds, the Reds are -112 favorites with the Cardinals at -106. With Singer in form and Pallante struggling, Cincinnati holds the advantage. My model projects a 5-4 Reds win, making them the better moneyline pick.
The total sits at 8.5 runs, with the over at -111 and under at -109. The Reds’ lineup has been inconsistent but capable of explosive innings, while St. Louis has been inconsistent against right-handers. My model projects 9 total runs, making the over the stronger play. For further breakdowns, visit MLB Picks and the Expert MLB Betting Guide.
Key Betting Trends
| Team | Last 10 Games | Moneyline Record | Over/Under Record |
|---|---|---|---|
| Cincinnati Reds | 4-6 | 3-7 | 6-4 |
| St. Louis Cardinals | 5-5 | 5-5 | 4-6 |
Additional betting trends to consider:
- The Reds are 5-2 in Brady Singer’s last seven starts.
- The Cardinals are 1-7 in Andre Pallante’s last eight outings.
- The over is 6-2 in the Reds’ last eight games against NL Central opponents.
Players to Watch
| Player | Team | Stat Highlight |
|---|---|---|
| Brady Singer | Reds | 3.94 ERA, 2.25 ERA in September |
| Sal Stewart | Reds | HR, 3 hits in 11-6 win vs Cardinals |
| Elly De La Cruz | Reds | Speed/power threat, key lineup piece |
| Thomas Saggese | Cardinals | .294 AVG in September, HR vs Reds |
| Alec Burleson | Cardinals | .283 AVG, consistent bat in lineup |
| Andre Pallante | Cardinals | 5.34 ERA, but 2.08 ERA vs Reds career |
Game Preview Recap
The Cincinnati Reds and St. Louis Cardinals wrap up their series in a game with contrasting motivations. Cincinnati is still chasing the final NL wild-card spot, while St. Louis is focused on development and evaluating players like Saggese with Masyn Winn sidelined.
Singer has been Cincinnati’s anchor, dominating in August and September and proving effective against St. Louis this season. Pallante has gone in the opposite direction, struggling badly since early August, but his career numbers against the Reds offer a sliver of optimism for the Cardinals.
The Reds’ offense remains streaky, alternating between big outbursts and being shut down. Sal Stewart and Elly De La Cruz are the key X-factors, while St. Louis will rely on Saggese, Burleson, and Donovan to manufacture runs.
This late-season matchup highlights the urgency for Cincinnati, who must win to stay in the playoff race. Fans can track updates with MLB Scores & Odds and review the Expert MLB Betting Guide for deeper wagering strategies.
