Chicago White Sox vs Baltimore Orioles Picks and Predictions September 17th 2025

Chicago White Sox vs Baltimore Orioles September 17th 2025

The Baltimore Orioles take on the Chicago White Sox at Rate Field. The Orioles hold a record of 71-80 and are on a two-game win streak. In their last ten games, they have won six. The White Sox, with a record of 57-95, are in a five-game losing streak and have won only three of their last ten games.

This afternoon game is set for September 17, 2025, at 2:10 PM. Tyler Wells will start for the Orioles, boasting an ERA of 2.31. Martín Pérez will pitch for the White Sox with an ERA of 3.27. Weather conditions are expected to be clear with a warm day and a calm crosswind.

Orioles vs White Sox Key Information

• Sport: Baseball
• Teams: Baltimore Orioles vs. Chicago White Sox
• Venue: Rate Field in Chicago, IL
• Date: Wednesday, September 17, 2025
• Betting Odds: Orioles Moneyline -124, White Sox Moneyline +105, Orioles Runline -1.5 (+135), White Sox Runline +1.5 (-161), Total Over 8.0 (-113), Total Under 8.0 (-107)

The Orioles Can Win If…

The Baltimore Orioles are coming off a narrow 8-7 win against the Chicago White Sox. Dylan Beavers was a key player, going 2-for-5 with a home run and three RBIs. Dean Kremer pitched 5 2/3 innings, allowing just two earned runs, which helped secure the win.

The Orioles have shown they can hit for power, ranking 13th in home runs with 179 this season. Their slugging percentage of .400 also ranks them 13th, demonstrating their ability to drive the ball deep. With hitters like Gunnar Henderson and Jackson Holliday leading the lineup, they have the potential to score big runs.

Tyler Wells will start for the Orioles, bringing a strong 2.31 ERA and a 0.60 WHIP to the mound. His ability to keep runners off base can be a game-changer. With Wells’ control and the Orioles’ power at the plate, they have a solid chance to win the upcoming game.

The White Sox Can Win If…

The Chicago White Sox are looking to bounce back after a close 8-7 loss to the Baltimore Orioles. In that game, Andrew Benintendi and Kyle Teel both hit home runs, contributing to the team’s seven runs. Lenyn Sosa also had a strong performance, going 2-for-4 with two RBIs.

The White Sox have some solid stats that show why they can win. They have hit 153 home runs this season, ranking 20th in the league. Their pitching staff has given up 174 home runs, which is 11th best, showing their ability to limit long balls.

Martín Pérez will start on the mound for the White Sox. He has a 3.27 ERA and a 1.05 WHIP, indicating his ability to keep games close. With strong performances from key players and a capable starting pitcher, the White Sox have a chance to secure a win against the Orioles.

The Lean

The Orioles are favored on the moneyline at -124 against the White Sox, who are at +105. The Orioles have a slight edge in hitting and pitching stats. My model projects the Orioles to win with a score of 5-3. With these factors, I recommend picking the Orioles to win straight up.

The total for the game is set at 8.0, with odds of -113 for the over and -107 for the under. The Orioles and White Sox have mid-tier pitching and hitting stats. My model projects a total score of 8 runs. Given this projection, I recommend taking the under 8.0 for this game.

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Latest Betting Trends

Key Betting Lines

• Orioles moneyline: around –125
• White Sox moneyline: +110
• Run line: Orioles –1.5 (+135) / White Sox +1.5 (–155)
• Total (Over/Under): 8 runs

Oddsmakers have installed Baltimore as a slight favorite on the road. The line reflects both the Orioles’ recent dominance over Chicago and the White Sox’s extended struggles. The run line offers plus-value for Baltimore bettors who believe the Orioles can win by multiple runs, while the total has been set at a moderate 8, reflecting mixed offensive trends for both clubs.

Recent Performance and Trends

• Baltimore has owned this matchup, going 9-1 in the last 10 head-to-head meetings.
• The Orioles have won seven straight at Guaranteed Rate Field, with their last loss there coming in April 2023.
• Chicago has dropped five games in a row and remains just ahead of Colorado in the league standings.
• Baltimore games on the road have frequently leaned toward the under, as their pitching has kept games tighter even while their offense has been inconsistent.
• Tuesday’s 8-7 result was an outlier, as the teams combined for 15 runs after a stretch of lower-scoring contests.

Betting Outlook

The moneyline favors Baltimore for good reason, as recent history shows they have consistently handled Chicago. The Orioles’ strong trend in head-to-head matchups suggests value in backing them outright. On the run line, Baltimore at –1.5 comes with enticing plus odds for bettors willing to back a more decisive win.

The total is more challenging. While Tuesday’s game shot past the number, the White Sox had scored just four total runs across their previous four games. Baltimore has also been involved in multiple unders on the road this season, making the under a reasonable angle if you expect regression back to low-scoring form.

For Chicago to cover or pull off the upset, their offense will need to replicate Tuesday’s breakout, with players like rookie catcher Kyle Teel continuing to provide power. Otherwise, the White Sox’s recent trends point toward another difficult day at the plate.

Orioles Continue Dominance in Chicago

The Baltimore Orioles are looking to finish off a three-game sweep when they face the Chicago White Sox on Wednesday afternoon. Baltimore secured the series with an 8-7 win on Tuesday, overcoming an early two-run deficit by putting up eight runs between the third and seventh innings. Chicago nearly completed a late rally with five runs in the eighth, but the Orioles held on.

This road series highlights a trend that has carried over for several years. The Orioles have now won seven straight games as the visitor against the White Sox and hold an 11-2 mark in Chicago since the start of the 2022 season. Their last loss on the South Side came on April 15, 2023. Fans tracking Baltimore’s late-season performance can review all recent outcomes through the MLB game results

Baltimore Playing Out the String

While their success in this matchup is notable, the Orioles’ season has been disappointing overall. Entering Wednesday at 71-80, Baltimore sits last in the AL East and was officially eliminated from postseason contention on Tuesday. Shortstop Gunnar Henderson admitted the team’s slow start buried them early, and the club was unable to recover despite occasional winning stretches.

On the mound, Tyler Wells (1-0, 2.31 ERA) will make his third start since returning from elbow surgery. Baltimore has won both of his outings so far, though Wells has struggled historically against the White Sox, carrying a 0-1 record with a 6.14 ERA in two appearances. Bettors looking for guidance on matchups like this can turn to MLB picks for expert insight.

White Sox Struggling Through Another Lost Season

Chicago enters the finale at 57-95, ahead of only the Colorado Rockies in the league standings. The White Sox have dropped five straight games, continuing a pattern of struggles that followed last season’s historically poor 121-loss campaign. Veteran left-hander Martin Perez (1-5, 3.27 ERA) will start, carrying a long track record against Baltimore with 16 career appearances but mixed results.

Despite another loss on Tuesday, Chicago finally showed signs of life offensively, scoring seven runs after managing just four total over their previous four games. Rookie catcher Kyle Teel has been a bright spot, adding a two-run homer as part of his 2-for-5 night. His late-season surge provides hope as Chicago looks toward the future. For a deeper breakdown of MLB matchups and betting strategies, fans can explore the MLB expert betting guide

Looking Ahead

For Baltimore, Wednesday is about continuing their dominance in Chicago and building confidence behind a healthy Wells. For the White Sox, the finale is another opportunity to find momentum and avoid being swept again at home. With both clubs long out of playoff contention, individual performances and development take center stage.

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