Nebraska Cornhuskers vs Michigan Wolverines Picks and Predictions September 20th 2025

Michigan vs Nebraska Picks and Predictions — September 21, 2025

The Michigan Wolverines head to Lincoln for a Big Ten opener clash with the unbeaten Nebraska Cornhuskers on Saturday. Michigan (2‑1) enters ranked No. 21 and coming off a 63‑3 demolition of Central Michigan, while Nebraska (3‑0) has overwhelmed opponents by 123 total points. The Huskers have won three straight but haven’t beaten a ranked team since 2016 — and Michigan has taken four straight in the series.

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Opening odds:

• Spread: Michigan −7
• Total (Over/Under): 53.5 points
• Moneyline: Michigan −275, Nebraska +225

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Nebraska Can Win If…

• They protect quarterback Dylan Raiola and establish a rhythm early. Raiola has been sharp — 76.6% completions, 829 yards, 8 TDs, no INTs — and has to lead from the front against Michigan’s physical defense.
• Their defense contains the run. Nebraska has allowed yards on the ground but leads the nation in pass defense, giving up just 66 yards per game. That strength must hold.
• They capitalize on home-field energy and start fast. A close first quarter gives the Huskers belief and puts pressure on a Michigan team dealing with coaching disruptions.

“This is a whole other animal,” coach Matt Rhule said of facing Michigan.

Michigan Can Win If…

• They stick to their identity. The Wolverines average 6.1 yards per carry and over 240 rushing yards per game. With Bryce Underwood breaking out as a dual threat, that ground game becomes even more dangerous.
• The defense disrupts Raiola’s rhythm. Michigan has the speed and strength up front to make Nebraska one-dimensional if it dominates early.
• The coaching staff keeps the team grounded. Interim coach Biff Poggi has been steady and leaned on experience. His messaging — letting players play — reflects confidence.

“Players win games. And you have to let your players play,” Poggi said.

Key NCAAF Betting Trends

The Lean

Pick: Michigan −7
Projected Final Score: Michigan 34, Nebraska 20

Reasoning: Michigan’s strength in the trenches, balanced offense, and rising quarterback play make them the sharper side. Nebraska is improved, but hasn’t faced a team close to this caliber. With the Wolverines’ ability to control time of possession and wear down defenses, they should cover a one-score spread comfortably.

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