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Seattle Seahawks vs New Orleans Saints September 21st 2025
The New Orleans Saints travel to Seattle to face the Seahawks in Week 3 of the 2025 NFL season. The game will take place at Lumen Field, with a kickoff scheduled for 4:05 PM on Sunday, September 21. Fans can catch the action on CBS, with the weather forecast predicting a mild day with light rain and a gentle breeze.
The Saints, led by Head Coach Kellen Moore, are looking to improve their 0-2 record. They will face the Seahawks, who have a 1-1 record under Head Coach Mike Macdonald. The last time these teams met, the Saints secured a win at home. This time, the Seahawks aim to defend their turf in front of their fans.
Saints vs Seahawks Key Information
- Sport: NFL
- Teams: New Orleans Saints vs. Seattle Seahawks
- Venue: Lumen Field in Seattle, WA USA
- Date: Sunday, September 21, 2025
- Betting Odds: Saints Moneyline +304, Seahawks Moneyline -382, Saints Spread +7.5 (-114), Seahawks Spread -7.5 (-105), Total Over 41.5 (-110), Total Under 41.5 (-110)
The New Orleans Saints will head to the Pacific Northwest to take on the Seattle Seahawks in what looks like a pivotal NFC showdown. Both teams have shown flashes, but Seattle enters with more momentum after taking down the Steelers. Bettors will have eyes on the spread, total, and key player matchups as this game could swing early season narratives in the NFC. For a full slate of expert breakdowns, check the weekly NFL picks section.
Game Odds
| Team | Spread | Moneyline | Total |
|---|---|---|---|
| New Orleans Saints | +7.5 (-110) | +285 | O 41.5 (-110) |
| Seattle Seahawks | -7.5 (-110) | -350 | U 41.5 (-110) |
(odds subject to change – for live updates visit the NFL scores and odds board)
The Saints Can Win If…
The Saints are trying to avoid an 0-3 start after a narrow 26-21 loss to San Francisco. Spencer Rattler delivered 207 passing yards and three touchdowns, while Alvin Kamara remains a dual threat with 99 rushing yards last week.
Defensively, Carl Granderson continues to pressure quarterbacks, adding two sacks against the 49ers. New Orleans needs a clean game offensively and a strong pass rush to upset Seattle. For deeper breakdowns on roster strengths and weaknesses, check the NFL teams hub.
The Seahawks Can Win If…
Seattle rebounded with a 31-17 win over Pittsburgh. Sam Darnold passed for 295 yards and two TDs, while Kenneth Walker III rushed for 105 yards. Their passing attack, led by Jaxon Smith-Njigba and Cooper Kupp, gives them elite weapons on the outside.
The Seahawks’ defense also showed its bite, forcing two turnovers against the Steelers. With Smith-Njigba already ranking near the top of the league in receiving, Seattle has the firepower and defense to cover as favorites. Learn more about Seattle’s season outlook in the NFL expert betting guide.
Key Betting Trends
| Trend | Stat |
|---|---|
| Saints ATS | 3-8 in last 11 games |
| Seahawks ATS | 6-3 in last 9 games |
| Total | Saints 2-1 to the over when total ≤ 42 |
| Total | Seahawks 3-1 to the over in last 4 games under 42.5 |
For season-long futures and how both teams stack up in the NFC, check the Super Bowl odds and predictions blog.
The Lean
Seattle is favored by 7.5, and my model projects a 24-14 Seahawks win. The Saints’ offense has sputtered late in games, while Seattle has the balance to keep extending drives. The recommendation: Seahawks -7.5.
Total is set at 41.5, and the projection calls for 38 points. With both defenses finding early rhythm, the under looks like the stronger play.
