San Diego Padres vs Arizona Diamondbacks Picks and Predictions September 26th 2025

San Diego Padres vs Arizona Diamondbacks September 26th 2025

The Arizona Diamondbacks will take on the San Diego Padres at PETCO Park. The Diamondbacks have a record of 80-79 and are ranked third in the NL West. They have lost their last two games but have a 6-4 record in their last ten games.

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The Padres hold a record of 87-72, sitting second in the division. They have dropped their last game but also have a 6-4 record over the last ten games. The game is set for Friday, September 26, 2025, at 9:40 PM, with a light rain forecasted. Yu Darvish is the starting pitcher for the Padres, while the Diamondbacks’ starter is yet to be announced.

Diamondbacks vs Padres Key Information

• Sport: Baseball
• Teams: Arizona Diamondbacks vs. San Diego Padres
• Venue: PETCO Park in San Diego, CA
• Date: Friday, September 26, 2025
• Betting Odds: Diamondbacks Moneyline +126, Padres Moneyline -150, Diamondbacks Runline +1.5 (-174), Padres Runline -1.5 (+145), Total Over 7.5 (-114), Total Under 7.5 (-105)

The Diamondbacks Can Win If…

The Arizona Diamondbacks are looking to bounce back after a tough 8-0 loss to the Los Angeles Dodgers. Despite the loss, Ketel Marte and Blaze Alexander showed potential with their hitting. Marte went 1 for 4 with a double, while Alexander added a single in his three at-bats.

The Diamondbacks have a strong lineup that can turn the tide in their favor. They rank 4th in slugging percentage at .433, showing they can hit for power. With 272 doubles, they are 5th in the league, which can help them score runs against the Padres.

The Diamondbacks have players who can make a difference. Geraldo Perdomo leads the team with a .289 batting average and 98 RBIs. Corbin Carroll adds power with 31 home runs, and Ketel Marte contributes with 26 home runs and a .283 average. These players can help the Diamondbacks secure a win.

The Padres Can Win If…

The San Diego Padres are coming off a recent 3-1 loss to the Milwaukee Brewers. Despite the loss, Dylan Cease delivered a strong performance on the mound, striking out eight batters over five innings. Jackson Merrill provided the Padres’ sole run with a home run, showing his potential to impact the game.

The Padres have shown they can win with their pitching. They rank third in the league with a 3.65 ERA and first in batting average against at .224. This strong pitching staff can keep games close and give their hitters a chance to shine.

Offensively, the Padres have key contributors like Manny Machado and Ryan O’Hearn. Machado leads the team with 26 home runs and 93 RBIs, while O’Hearn has a solid .278 batting average. With these players in the lineup, the Padres have the ability to score runs and secure a win.

Padres vs Diamondbacks MLB Betting Preview

The San Diego Padres (87-72) return to Petco Park with hopes of catching Chicago for home-field advantage in the wild-card round. They trail the Cubs by two games with three left. Arizona (80-79) enters needing a sweep to stay alive in the NL race after back-to-back losses to the Dodgers.

For full market updates across the league, see the latest MLB odds page.

Line Movement and Odds

San Diego opened around -125 with Yu Darvish on the mound. The total is 8 runs. Early betting has tilted toward the Padres, though sharp money has been steady on Arizona. The Cubs’ Thursday loss to the Mets has shifted some public momentum San Diego’s way.

Matchup Breakdown

Padres: Yu Darvish (4-5, 5.51 ERA) owns a 3.78 ERA in 21 career starts against Arizona, but he’s been hittable this year. He allowed two runs over 4 2/3 innings against the White Sox in his last start. Losing Ramon Laureano to a fractured finger further dents San Diego’s lineup. For more roster context, visit the San Diego Padres team page.

Diamondbacks: Zac Gallen (13-14, 4.70 ERA) has turned sharp in September, posting a 2.56 ERA across his past five starts. He’s 5-3 with a 3.12 ERA lifetime against San Diego. Arizona still has the tiebreaker over New York but trails both the Mets and Reds. See the Arizona Diamondbacks team page for complete trends.

Injuries and Conditions

• Padres: Laureano (finger) is out through the wild-card round.
• Diamondbacks: Enter relatively healthy but with bullpen usage stretched.

Clear skies are expected in San Diego. Night games at Petco Park tend to favor pitchers, adding weight to under bets.

Best Bets and Prediction

San Diego’s bullpen depth and home-field edge are countered by Gallen’s current form and Arizona’s desperation. Expect a tight opener.

Projected score: Diamondbacks 4, Padres 3
Best Bet: Arizona +1.5 runline
Lean: Under 8 runs

Where to Find More Picks

For more angles on Friday’s card, dive into the MLB picks section and sharpen your approach with the MLB expert betting guide.