San Francisco Giants vs Colorado Rockies Picks and Predictions September 28th 2025

San Francisco Giants vs Colorado Rockies September 28th 2025

The Colorado Rockies will take on the San Francisco Giants at Oracle Park on Sunday, September 28, 2025. The Rockies have struggled this season with a record of 43-118 and are on a five-game losing streak. They are ranked fifth in the NL West Division.

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The Giants, on the other hand, hold a record of 80-81 and are third in the division. They have won their last three games and have a balanced home record of 41-39. The game is set for an afternoon start at 3:05 PM, with overcast skies expected at the outdoor stadium.

Rockies vs Giants Key Information

• Sport: Baseball
• Teams: Colorado Rockies vs. San Francisco Giants
• Venue: Oracle Park in San Francisco, CA
• Date: Sunday, September 28, 2025
• Betting Odds: Rockies Moneyline +240, Giants Moneyline -295, Rockies Runline +1.5 (+118), Giants Runline -1.5 (-142), Total Over 7.5 (-112), Total Under 7.5 (-108)

Giants vs Rockies MLB Betting Preview

The San Francisco Giants (80-81) and Colorado Rockies (43-118) finish their seasons Sunday at Oracle Park. Both clubs are out of contention, and both managers enter the offseason with uncertain futures. For roster context, see the San Francisco Giants team page.

Colorado has dropped five straight but saw rookie McCade Brown flash upside in Seattle with 10 strikeouts earlier this week. More team notes are on the Colorado Rockies team page.

The Rockies Can Win If…

McCade Brown (0-4, 7.54 ERA) builds on his 10-strikeout performance and keeps the ball in the park. Colorado’s offense must lean on Hunter Goodman (31 HR) and Jordan Beck to supply power against Logan Webb. The Rockies hit three homers in Saturday’s loss and need similar pop to support their rookie starter.

The Giants Can Win If…

Logan Webb (14-11, 3.30 ERA) delivers a quality start, as he has often against Colorado (10-3, 3.12 ERA in his career vs the Rockies). San Francisco’s lineup, led by Rafael Devers (34 HR, 108 RBIs), must cash in with runners on base. If Casey Schmitt and Willy Adames provide support, the Giants can control the finale and end above last year’s win total.

Matchup Breakdown

Rockies: Brown has shown flashes but still owns a 7.54 ERA. Colorado’s 6.01 team ERA ranks last in MLB. Offensively, Goodman’s 31 homers lead a lineup that sits 14th in doubles. The Rockies’ path is hitting homers and hoping their rookie can limit damage.

Giants: Webb is making his 34th start, a career high. The Giants’ 3.88 team ERA ranks 13th, and their offense has surged behind Devers and Schmitt late in the season. San Francisco is looking for one more win to top its 2024 total.

Compare the two clubs on the MLB teams page.

Injuries and Conditions

• Rockies: Healthy but extremely young roster, relying on rookies like Beck and Goodman.
• Giants: Healthy veterans with regulars in the lineup.

Weather: Clear afternoon at Oracle Park, slight marine layer could suppress homers.

Best Bets and Prediction

Webb has a proven track record vs Colorado, while the Rockies are limping to the finish line. San Francisco’s pitching edge is decisive.

Projected score: Giants 5, Rockies 3
Best Bet: Giants moneyline -295
Lean: Over 7.5 runs (-112) — Rockies’ bullpen makes late scoring likely.

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