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Indiana Hoosiers vs UCLA Bruins Game Preview
The Indiana Hoosiers host the UCLA Bruins on Saturday, October 25, 2025, at Memorial Stadium in Bloomington, IN. Kickoff is set for 12:00 PM ET, with national coverage on FOX.
Indiana (7-0, 4-0 Big Ten) has climbed to its highest-ever ranking at No. 2 after a dominant 38-13 win over Michigan State. The Hoosiers are undefeated and surging toward College Football Playoff contention under coach Curt Cignetti.
UCLA (3-4, 3-1 Big Ten) has been rejuvenated under interim coach Tim Skipper, winning three straight games, including last week’s 20-17 victory over Maryland. The Bruins will now face their toughest test of the season against one of the nation’s hottest teams.
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Line Movement and Betting Odds
Indiana Moneyline: -1400
UCLA Moneyline: +780
Indiana Spread: -21.5 (-110)
UCLA Spread: +21.5 (-110)
Total Over/Under: 59.0 (-110)
Oddsmakers opened Indiana as heavy home favorites, reflecting their unbeaten record and dominant performances in recent weeks. UCLA’s recent win streak has generated some underdog interest, but the market remains firmly in the Hoosiers’ favor.
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Matchup Breakdown
Indiana’s success has been driven by quarterback Fernando Mendoza, who has emerged as a Heisman contender. The Cal transfer has thrown for 1,755 yards and 21 touchdowns with only two interceptions, completing over 73% of his passes. The Hoosiers average 43.9 points per game and rank fourth nationally in scoring.
Wide receiver Omar Cooper Jr. (522 yards, 5 TDs) continues to shine as Mendoza’s top target, while running back Jaylin Lucas adds versatility out of the backfield with eight total touchdowns. Indiana’s defense has also been elite, allowing just 84 rushing yards per game and ranking among the Big Ten leaders in sacks.
UCLA’s turnaround has come from quarterback Nico Iamaleava’s dynamic play. The Tennessee transfer has thrown for 1,355 yards and 10 touchdowns while rushing for a team-best 360 yards and four more scores. His dual-threat ability keeps defenses guessing, but his availability this week is uncertain after he exited the Maryland win with a knee injury.
The Bruins’ defense has been physical and opportunistic, holding opponents to under 18 points per game during their three-game win streak. Linebacker Darius Muasau and edge rusher Gabriel Murphy have led a disruptive front that will be tested by Indiana’s efficient offensive line.
Get advanced team stats and historical matchup data in the expert betting guide.
Key Storylines
• Indiana is 7-0 for the first time since 1967 and has won five straight Big Ten games by double digits.
• UCLA has found new life under interim coach Tim Skipper, going 3-1 since his promotion.
• Fernando Mendoza’s elite passing efficiency has been the foundation of Indiana’s rise.
• The Bruins’ defense has forced seven turnovers in their last three games.
• This is only the second-ever meeting between the programs; Indiana won 42-13 last season in Pasadena.
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Injury Report
Indiana Hoosiers:
Quarterback Fernando Mendoza (healthy) will start. Running back Christian Turner (ankle) and wide receiver Cam Camper (knee) are questionable. Defensive back Noah Pierre (shoulder) remains day-to-day.
Full injury report for Indiana Hoosiers
UCLA Bruins:
Quarterback Nico Iamaleava (knee) is questionable. Defensive end Laiatu Latu (neck) is out. Tight end Hudson Habermehl (undisclosed) and linebacker JonJon Vaughns (ankle) are both questionable.
Full injury report for UCLA Bruins
Prediction
Indiana’s balance, discipline, and home-field advantage make them a tough matchup for any opponent. UCLA’s progress under Tim Skipper is impressive, but the Hoosiers’ defensive depth and offensive precision should control this game.
Projected Score: Indiana 42, UCLA 17
Best Bet: Indiana -21.5 (-110)
Secondary Lean: Under 59.0 (-110)
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