Ohio State Buckeyes vs Ucla Bruins Picks and Predictions November 15th 2025

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UCLA vs Ohio State Game Preview

The No. 1 Ohio State Buckeyes continue their march toward a second straight national championship, hosting a roller-coaster UCLA Bruins squad looking to stop yet another downturn. While Ohio State has dominated the national conversation with historic defensive efficiency, UCLA enters Columbus fighting to stay afloat after back-to-back losses.

Ohio State’s résumé remains the cleanest in the country. The Buckeyes lead the nation in scoring defense, total defense and red-zone prevention, a three-phase profile rarely seen at this stage of the season. Their 9-0 record includes only two single-digit games, and their Big Ten dominance has positioned them firmly at No. 1 on the College Football Playoff board.

UCLA’s story has been the opposite. After an 0-3 start cost DeShaun Foster his job, the Bruins surged briefly under interim coach Tim Skipper before crashing against Indiana and Nebraska. Now 3-6, UCLA faces its toughest assignment of the season in a venue that rarely offers opponents any relief.

For bettors tracking market movement and late-season volatility, this matchup aligns with the sharper patterns found across the college football odds board and the weekly projections offered on the college football picks page.

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Odds and Key Information

Ohio State has opened as a heavy favorite, reflecting its elite defense and UCLA’s offensive inconsistency. Totals have seen early pressure to the under, driven by Ohio State’s defensive numbers and UCLA’s recent struggles to sustain drives.

For bettors modeling risk-reward edges, concepts in the NFL expert betting guide translate directly into late-season college football environments like this one.

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Ohio State Outlook

Ohio State has shaped its identity around defensive suffocation. The Buckeyes allow only 7.2 points per game and fewer than 212 yards of offense, numbers that have made opponents deeply uncomfortable from the opening quarter. Junior linebacker Arvell Reese has emerged as the engine of the unit, delivering a team-best 55 tackles and 6.5 sacks while elevating the Buckeyes’ physicality at every level.

On offense, Heisman contender Julian Sayin continues to unlock Ryan Day’s vertical passing structure. Sayin threw for 303 yards last week against Purdue, connecting with star receiver Jeremiah Smith for 137 yards and a touchdown. The Buckeyes have leaned heavily on efficient ball control and red-zone precision, complementing a defense that rarely gives opposing quarterbacks a clean read.

If Ohio State maintains rhythm early, UCLA’s defensive front will be at immediate risk of being overwhelmed. Expect Ohio State to press advantages on the perimeter, force UCLA into predictable passing downs and let their defense dictate tempo.

UCLA Outlook

UCLA’s season has swung between unexpected surges and dramatic collapses. Interim coach Tim Skipper engineered a midseason rebound before consecutive losses exposed familiar structural issues. The Bruins enter this matchup with a defense that struggles to contain explosive plays and an offense that leans heavily on quarterback Nico Iamaleava’s improvisation.

Iamaleava remains a dynamic runner but absorbs significant punishment behind an inconsistent offensive line. He was sacked three times last week against Nebraska and took repeated hits as he tried to manufacture rushing lanes. His only prior appearance in Ohio Stadium ended with 14 completions on 31 attempts and four sacks in a decisive CFP loss to the Buckeyes.

The Bruins need clean pockets, sustained drives and red-zone efficiency to match Ohio State’s scoring pace — areas that have been problematic all season. Without major offensive gains, UCLA risks falling behind early and becoming one-dimensional.

Key Matchup Table

CategoryEdge
Quarterback PlayOhio State
Defensive EfficiencyOhio State
Explosive PlaysOhio State
Run Game VarianceUCLA

Betting Trends

• Ohio State is 14-1 straight up in its last 15 Big Ten home games
• Ohio State is 9-3 to the under in its last 12 home games
• UCLA is 1-8 ATS in its last nine road games
• UCLA overs are 4-1 in its last five games as an underdog
• Ohio State is 10-1 straight up in its last 11 games versus teams below .500
• UCLA is 0-4 ATS in its last four road games vs top-10 opponents

Prediction

Ohio State enters with a near-perfect defensive profile and a top-tier passing attack. UCLA’s inconsistency, offensive protection issues and turnover vulnerability create a matchup that heavily favors the Buckeyes in the trenches and on the perimeter. The Bruins may generate a few explosive quarterback runs, but sustained offense will be a challenge.

Projection:
Ohio State 38, UCLA 10

Spread Lean: Ohio State -27.5
Total Lean: Under 48.5

Why You Need Picks

Games with massive spreads and elite defenses require sharper modeling than casual bettors apply. Identifying derivative value — team totals, first-half lines, correlated props — is easier when using verified projections and historical patterns available on the Handicappers Leaderboard.

Pairing expert evaluations with deep-dive resources like the NFL betting strategy guide ensures stability in late-season wagering, especially in mismatches where the public tends to overreact to ranking gaps.

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