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Game Preview Iowa State Cyclones @ Creighton Bluejays
The Iowa State Cyclones face the Creighton Bluejays in a non-conference clash Tuesday, November 25, 2025, at Michelob ULTRA Arena in Las Vegas. Tip-off is set for 2:00 PM ET in the second day of the Players Era men’s championship, with Iowa State coming off a dramatic 83-82 win over St. John’s and Creighton looking to bounce back after falling to Baylor.
Iowa State moved to 5-0 but may be without key guard Tamin Lipsey, who exited Monday’s game late with a lower-body injury. Lipsey, along with Joshua Jefferson, averages 18.4 points per game and is central to the Cyclones’ fast-paced, efficient offense. Freshman Milan Momcilovic stepped up with 23 points and the go-ahead basket in the final two minutes against the Red Storm.
Creighton dropped to 3-2 following an 81-74 loss to Baylor. The Bluejays were outrebounded by 17 and struggled defensively in the first half, according to head coach Greg McDermott. However, they received a major lift from freshman Hudson Greer, who scored 16 points on 7-of-8 shooting in just his second appearance.
This game features a coaching reunion between McDermott and Iowa State’s T.J. Otzelberger, who was once his assistant. But sentiment will take a backseat to a key early-season test for both squads.
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Odds and Key Information
| Category | Advantage |
|---|---|
| Offensive Efficiency | Iowa State |
| Interior Defense | Creighton |
| Guard Experience | See NCAAB odds and scores for real-time updates |
| Bench Scoring | Creighton |
| Coaching Edge | Even |
Iowa State Cyclones Outlook
Iowa State enters this matchup averaging 95.5 points per game, ranking 14th nationally. The Cyclones shoot 54.2% from the field, good for 5th in the country, and feature a balanced attack with Lipsey, Jefferson, and Momcilovic all capable of leading the offense.
Lipsey’s status is in question after a lower-body injury, and his absence could significantly impact Iowa State’s ball-handling and tempo. Still, their depth was on display against St. John’s, with Jefferson adding 17 points and 8 boards and Momcilovic leading the way in crunch time.
The Cyclones are 5-0 straight up and 3-2 against the spread, including a perfect 3-0 when listed as favorites. Their defensive identity remains strong, holding opponents to 38.4% shooting despite Monday’s close call.
Otzelberger’s team has now beaten a ranked opponent and seeks to build on its postseason résumé in Las Vegas. Explore similar value picks from the NCAAB picks section.
Creighton Bluejays Outlook
Creighton is 3-2 after losses to Baylor and one other power-conference team. The Bluejays are scoring 78.5 points per game and rank 29th nationally in two-point shooting (61.8%). They’ve shown potential with interior scoring and rebounding, but consistency on defense remains an issue.
Freshman Hudson Greer has provided an unexpected boost. In just his second game, he led the team in scoring and shot 87.5% from the floor against Baylor. Blake Harper leads the team in points (12.2) and rebounds (7.5) per game, while Josh Dix contributes 11.8 PPG and added six assists in their last outing.
The Bluejays’ success hinges on whether they can limit Iowa State’s ball movement and avoid being overwhelmed on the glass, an area that hurt them against Baylor. They are 2-3 ATS this season and haven’t covered as an underdog.
Creighton will need to rediscover its early-season rhythm and avoid extended scoring droughts if they hope to pull the upset on a neutral floor.
Betting Trends
- Iowa State is 5-0 SU and 3-2 ATS
- The Cyclones are 3-0 ATS as favorites
- Creighton is 3-2 SU and 2-3 ATS
- The Bluejays are 0-2 ATS as underdogs
- Iowa State is 4-1 to the over this season
- The Cyclones have won 7 straight vs Creighton since 1991
For sharp betting movement and projections, follow NCAAB picks across today’s board.
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Prediction
Iowa State’s offense is simply clicking at a higher level than Creighton’s right now, and even if Lipsey is limited, the Cyclones’ depth and shooting should be enough to create separation. Creighton will need big performances from their freshmen and must rebound better than they did against Baylor to stay in it.
With Iowa State’s 95.5 PPG and shooting percentages near the top of the nation, they are poised to cover the 9.5-point spread, especially if Creighton’s defensive lapses continue.
Projected Score: Iowa State 92, Creighton 80
Pick: Iowa State -9.5
Total Lean: Over 151.5
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