DePaul Blue Demons vs Seton Hall Pirates Picks and Predictions January 24th 2026

Seton Hall heads to Chicago to face DePaul on Saturday, January 24, 2026 at 5:00 PM ET at Wintrust Arena. This Big East conference game will be broadcast on truTV. Seton Hall comes in 14-5 and has been strong away from home at 5-1, while DePaul is 11-8 and has been tough in its own building with a 10-4 home record.

Seton Hall is a small road favorite at -2.5 with a total of 133.5. That’s a tight market number for two teams that have both played well in their preferred settings. It also suggests a slower, more physical game where each possession matters, which usually makes spread value more about late-game execution than raw talent gaps.

Seton Hall Pirates vs DePaul Blue Demons Odds

These are the current betting lines, and bettors should always monitor movement and shop for the best number on the latest college basketball odds.

Team	Moneyline	Spread	Total
Seton Hall Pirates	-154	-2.5 (-112)	O 133.5
DePaul Blue Demons	+123	+2.5 (-110)	U 133.5

Seton Hall Pirates Betting Form

Seton Hall is coming off a five-point loss to St. John’s, and the box score tells you the type of team they are. Stephon Payne grabbing 15 rebounds is not a random stat, it’s how Seton Hall stays in games when the offense isn’t perfect. They can win the possession battle with rebounding and pressure defense, and that’s a nice profile for a short road favorite because it reduces the reliance on hot shooting.

The free throw angle matters too. Seton Hall makes 16.2 free throws per game, so they have a way to score when the half-court offense gets sticky. And their defense creates disruption, with 9.5 steals per game, which can flip a few possessions into easy points. In a game lined -2.5, two or three “free” transition buckets can be the difference between winning and pushing. If you want a simple way to track how Seton Hall has been performing across recent games and where the results have come from, the Seton Hall stats and results hub is a clean reference.

The only real concern is that Seton Hall has had moments where it goes cold for a few minutes and has to win ugly. That’s fine if the defense is locked in. It’s not fine if DePaul is scoring comfortably.

DePaul Blue Demons Betting Form

DePaul just lost to Butler by seven, but scoring 80 in a conference game is still notable. Layden Blocker and CJ Gunn giving them 36 combined shows the offense can produce even when the outcome is a loss. The home record is the bigger story. DePaul is 10-4 at Wintrust Arena, and they’ve been more comfortable there, especially offensively.

For betting, DePaul’s strength is that it can look very different depending on game flow. If they get into rhythm early, they can score enough to make +2.5 feel valuable and also push this total up. If they start slow and let Seton Hall dictate the physicality, DePaul can get stuck trading tough shots for Seton Hall free throws and transition steals.

One small note: DePaul’s success as favorites isn’t directly relevant here because they’re the dog, but the broader idea is that they tend to play better when they’re not chasing a game. If Seton Hall lands the first run, DePaul’s margin for error shrinks.

Seton Hall Pirates vs DePaul Blue Demons Matchup Breakdown

This looks like a possession game. Seton Hall wants to defend, pressure, rebound, and get to the line. DePaul wants cleaner shot quality and fewer live-ball mistakes. If DePaul takes care of the ball, it can absolutely win this game. If it doesn’t, Seton Hall’s pressure becomes a scoring tool, not just a defensive trait.

The total being 133.5 is a signal. Oddsmakers expect a slower, more physical Big East game rather than a clean up-and-down track meet. That usually favors the team that can create points without needing jump shots, which points back to Seton Hall’s free throws and defensive disruption. But there is an Over path too, and it’s simple: if DePaul’s guards are comfortable and the game stays within a possession late, you’ll get more free throws, more late-clock fouling, and more possessions that end with points.

Thinking about how late-game pace and fouling changes totals is important in low totals like this. The sports betting strategy guide has a useful framework for that kind of game state analysis.

Off Board

Jan 25, 2026 16:02 EST

Score

–

Spread

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o+159.00-108

Total

u+159.00-108

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Moneyline

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10 Picks Available

Off Board

Jan 25, 2026 16:00 EST

Score

+3.00 -106

Spread

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o+143.00-114

Total

u+143.00-103

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Moneyline

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4 Picks Available

Final

Jan 25, 2026 15:00 EST

Score

–

Spread

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o+148.50-108

Total

u+148.50-108

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Moneyline

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5 Picks Made

Seton Hall Pirates vs DePaul Blue Demons Predictions and Best Bets

I lean Seton Hall -2.5. The matchup fits them. Their ability to generate steals and win the free throw battle is a clean way to cover a short number on the road, and the 5-1 away record suggests they’ve handled hostile environments well this season. DePaul can absolutely win if it protects the ball and gets efficient guard play, but that’s exactly what Seton Hall is built to disrupt.

On the total, I lean Over 133.5. The number is low enough that a fairly normal game can get there if both teams land in the low 70s, and the best Over angle is a close finish. If this is a one-possession game in the final two minutes, the free throw parade can push it over even if the first half is a bit choppy. The risk is a game where Seton Hall controls pace and DePaul’s offense stalls, because then you can land in the mid-60s and never threaten 134.

Best Bet: Seton Hall Pirates -2.5 (-112).

NCAAB Picks and Handicappers on ScoresAndStats

Big East lines often come down to a few possessions because these teams know each other and the games are physical. That’s why it helps to compare several angles on the slate rather than locking in on one matchup and forcing a play.

ScoresAndStats makes it easier to approach college hoops that way with today’s college basketball picks. If you’re tracking multiple games and want a clean hub for schedules and team context while you shop numbers, the NCAAB teams page is a useful shortcut.