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Both teams lost in Week 1. Here is where this game stands before Week 2 is played.
The game
The Panthers visit the Browns on Sunday 27 September at 1:00 PM ET. The game is in Cleveland. It crosses the conferences, NFC South against AFC North.
The Browns finished 2025 at 5-12 and the Panthers at 8-9. They did not play each other in 2025.
Week 1
The Panthers lost to the Bears 59-37 at home, failing to cover as a 3-point underdog. The Browns lost to the Jaguars 34-10 on the road, failing to cover as a 9-point underdog.
That leaves the Panthers at 0-1 and the Browns at 0-1. Both play again in Week 2 before this game.
The early line
The early line has the Panthers by 3, the median of 7 books, which range from 2.5 to 3. The total is 40, from 39.5 to 40.5 across books.
With the bookmaker margin removed, the moneyline makes the Panthers 57.2% to win. These are early prices, read on 17 September 2026 at 06:14 UTC, and Week 2 will move them.
Carolina Panthers at Cleveland Browns, Sunday 27 September 2026, 1:00 PM ET. Prices: US sportsbooks via Nucleus, read 17 September 2026, 06:14 UTC. 2025 results: Nucleus, checked game by game against ESPN. Every Week 3 game: NFL Week 3 odds and predictions.
