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Both teams lost in Week 1. Here is where this game stands before Week 2 is played.
The game
The Rams visit the Broncos on Sunday 27 September at 8:20 PM ET. The game is in Denver. It crosses the conferences, NFC West against AFC West.
The Broncos finished 2025 at 14-3 and the Rams at 12-5. They did not play each other in 2025.
Week 1
The Rams lost to the 49ers 27-7 in Melbourne, a neutral site, failing to cover as a 3.5-point favourite. The Broncos lost to the Chiefs 31-10 on the road, failing to cover as a 1.5-point underdog.
That leaves the Rams at 0-1 and the Broncos at 0-1. Both play again in Week 2 before this game.
The early line
The early line has the Rams by 2.5 at all 7 books quoting it. The total is 46.5, from 45.5 to 46.5 across books.
With the bookmaker margin removed, the moneyline makes the Rams 54.8% to win. These are early prices, read on 17 September 2026 at 06:14 UTC, and Week 2 will move them.
Los Angeles Rams at Denver Broncos, Sunday 27 September 2026, 8:20 PM ET. Prices: US sportsbooks via Nucleus, read 17 September 2026, 06:14 UTC. 2025 results: Nucleus, checked game by game against ESPN. Every Week 3 game: NFL Week 3 odds and predictions.
