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The Texans won the last meeting 38-30. Here is where this one stands before Week 2 is played.
The game
The Texans visit the Colts on Sunday 27 September at 1:00 PM ET. The game is in Indianapolis. It is a division game in the AFC South, so both teams play each other twice this season.
The Colts finished 2025 at 8-9 and the Texans at 12-5. They met twice in 2025: the Texans won 20-16 at the Colts, then the Texans won 38-30 at home.
Week 1
The Texans lost to the Bills 36-31 at home, failing to cover as a 1-point underdog. The Colts lost to the Ravens 41-23 at home, failing to cover as a 3-point underdog.
That leaves the Texans at 0-1 and the Colts at 0-1. Both play again in Week 2 before this game.
The early line
The early line has the Texans by 2.5 at all 7 books quoting it. The total is 44.5, from 44.5 to 45.5 across books.
With the bookmaker margin removed, the moneyline makes the Texans 56.2% to win. These are early prices, read on 17 September 2026 at 06:14 UTC, and Week 2 will move them.
Houston Texans at Indianapolis Colts, Sunday 27 September 2026, 1:00 PM ET. Prices: US sportsbooks via Nucleus, read 17 September 2026, 06:14 UTC. 2025 results: Nucleus, checked game by game against ESPN. Every Week 3 game: NFL Week 3 odds and predictions.
