2026 College Football Week 4 Odds and Predictions

Graphic displaying matchups and predictions for 2025 NCAA football Week 4, featuring team logos and vibrant colors.

Of course, we’ll go over all of the college football week 4 point spreads and game totals when looking at all of the top matchups below. Need more advice beyond our preferred picks and predictions when betting on college football week 4 lines? Just check out the top sports betting handicappers before finalizing your bets.

Our college football predictions for Week 4 of the 2026 season: 123 games, each with its own page, listed 25 September 2026. Each page gives the line, our number and the call, or says plainly that the numbers do not support a bet.

Last week’s results are on the Week 3 page, and the full list of current predictions is on our college football predictions hub.

Friday 25 September

Prediction
Northwestern at Indiana Best Pick, Prediction and Odds
Army at Temple Best Pick, Prediction and Odds
Clemson at California Best Pick, Prediction and Odds
Navy at UAB Best Pick, Prediction and Odds

Saturday 26 September

Prediction
Central Michigan at Miami Best Pick, Prediction and Odds
Illinois at Ohio State Best Pick, Prediction and Odds
Notre Dame at Purdue Best Pick, Prediction and Odds
Oklahoma at Georgia Best Pick, Prediction and Odds
Ole Miss at Florida Best Pick, Prediction and Odds
Oregon at USC Best Pick, Prediction and Odds
Sam Houston at Texas Tech Best Pick, Prediction and Odds
South Carolina at Alabama Best Pick, Prediction and Odds
Texas A&M at LSU Best Pick, Prediction and Odds
Texas at Tennessee Best Pick, Prediction and Odds
Wisconsin at Penn State Best Pick, Prediction and Odds
Air Force at Nevada Best Pick, Prediction and Odds
Arizona at Washington State Best Pick, Prediction and Odds
Ball State at Kent State Best Pick, Prediction and Odds
Boise State at Western Michigan Best Pick, Prediction and Odds
Bucknell at Pittsburgh Best Pick, Prediction and Odds
Central Arkansas at Florida State Best Pick, Prediction and Odds
Colorado at Baylor Best Pick, Prediction and Odds
Colorado State at UTSA Best Pick, Prediction and Odds
Delaware at Virginia Best Pick, Prediction and Odds
Florida Atlantic at UL Monroe Best Pick, Prediction and Odds
Gardner-Webb at Marshall Best Pick, Prediction and Odds
Georgia Tech at Stanford Best Pick, Prediction and Odds
Hawai’i at Wyoming Best Pick, Prediction and Odds
Houston at Georgia Southern Best Pick, Prediction and Odds
Houston Christian at North Texas Best Pick, Prediction and Odds
Incarnate Word at Texas State Best Pick, Prediction and Odds
Iowa at Michigan Best Pick, Prediction and Odds
James Madison at Old Dominion Best Pick, Prediction and Odds
Kansas State at Cincinnati Best Pick, Prediction and Odds
Kennesaw State at Arkansas State Best Pick, Prediction and Odds
Lindenwood at Eastern Michigan Best Pick, Prediction and Odds
Long Island University at Florida International Best Pick, Prediction and Odds
Louisiana at Charlotte Best Pick, Prediction and Odds
Massachusetts at Sacramento State Best Pick, Prediction and Odds
Mercyhurst at Western Kentucky Best Pick, Prediction and Odds
Middle Tennessee at Jacksonville State Best Pick, Prediction and Odds
Minnesota at Washington Best Pick, Prediction and Odds
Missouri at Mississippi State Best Pick, Prediction and Odds
Missouri State at SMU Best Pick, Prediction and Odds
Nebraska at Michigan State Best Pick, Prediction and Odds
New Mexico at New Mexico State Best Pick, Prediction and Odds
North Carolina Central at East Carolina Best Pick, Prediction and Odds
Oklahoma State at West Virginia Best Pick, Prediction and Odds
Oregon State at UTEP Best Pick, Prediction and Odds
Rice at Fresno State Best Pick, Prediction and Odds
Robert Morris at Buffalo Best Pick, Prediction and Odds
San Diego State at Toledo Best Pick, Prediction and Odds
South Alabama at Kentucky Best Pick, Prediction and Odds
Southern Miss at Tulane Best Pick, Prediction and Odds
South Florida at Bowling Green Best Pick, Prediction and Odds
Stonehill at Ohio Best Pick, Prediction and Odds
TCU at UCF Best Pick, Prediction and Odds
Troy at Utah State Best Pick, Prediction and Odds
Tulsa at Arkansas Best Pick, Prediction and Odds
UCLA at Maryland Best Pick, Prediction and Odds
UConn at Miami (OH) Best Pick, Prediction and Odds
UNLV at Akron Best Pick, Prediction and Odds
Utah at Iowa State Best Pick, Prediction and Odds
Vanderbilt at Auburn Best Pick, Prediction and Odds
Virginia Tech at Boston College Best Pick, Prediction and Odds
Wake Forest at Louisville Best Pick, Prediction and Odds
William & Mary at Duke Best Pick, Prediction and Odds

Thursday 1 October

Prediction
North Texas at Tulsa Best Pick, Prediction and Odds
Western Kentucky at New Mexico State Best Pick, Prediction and Odds

Friday 2 October

Prediction
Liberty at Delaware Best Pick, Prediction and Odds
Penn State at Northwestern Best Pick, Prediction and Odds
Pittsburgh at Virginia Tech Best Pick, Prediction and Odds

Saturday 3 October

Prediction
Akron at Central Michigan Best Pick, Prediction and Odds
Alabama at Mississippi State Best Pick, Prediction and Odds
Arkansas at Texas A&M Best Pick, Prediction and Odds
Arkansas State at Louisiana Best Pick, Prediction and Odds
Army at Louisiana Tech Best Pick, Prediction and Odds
Auburn at Tennessee Best Pick, Prediction and Odds
Baylor at Arizona State Best Pick, Prediction and Odds
Boston College at SMU Best Pick, Prediction and Odds
Bowling Green at Miami (OH) Best Pick, Prediction and Odds
BYU at TCU Best Pick, Prediction and Odds
California at UNLV Best Pick, Prediction and Odds
Cincinnati at Arizona Best Pick, Prediction and Odds
Eastern Michigan at Massachusetts Best Pick, Prediction and Odds
Florida at Missouri Best Pick, Prediction and Odds
Fresno State at Washington State Best Pick, Prediction and Odds
Georgia Southern at Coastal Carolina Best Pick, Prediction and Odds
Indiana at Rutgers Best Pick, Prediction and Odds
Kentucky at South Carolina Best Pick, Prediction and Odds
Marshall at James Madison Best Pick, Prediction and Odds
Maryland at Nebraska Best Pick, Prediction and Odds
Memphis at Charlotte Best Pick, Prediction and Odds
Miami at Clemson Best Pick, Prediction and Odds
Michigan at Minnesota Best Pick, Prediction and Odds
Michigan State at Wisconsin Best Pick, Prediction and Odds
Middle Tennessee at Kansas Best Pick, Prediction and Odds
Navy at Air Force Best Pick, Prediction and Odds
Notre Dame at North Carolina Best Pick, Prediction and Odds
Ohio at Kent State Best Pick, Prediction and Odds
Ohio State at Iowa Best Pick, Prediction and Odds
Oregon State at Colorado State Best Pick, Prediction and Odds
Purdue at Illinois Best Pick, Prediction and Odds
Samford at UAB Best Pick, Prediction and Odds
San José State at Hawai’i Best Pick, Prediction and Odds
Stanford at Wake Forest Best Pick, Prediction and Odds
Syracuse at UConn Best Pick, Prediction and Odds
Temple at South Florida Best Pick, Prediction and Odds
Texas Southern at Florida Atlantic Best Pick, Prediction and Odds
Texas State at San Diego State Best Pick, Prediction and Odds
Texas Tech at Colorado Best Pick, Prediction and Odds
Toledo at Ball State Best Pick, Prediction and Odds
UCF at Houston Best Pick, Prediction and Odds
UL Monroe at South Alabama Best Pick, Prediction and Odds
Utah State at Boise State Best Pick, Prediction and Odds
UTEP at New Mexico Best Pick, Prediction and Odds
UTSA at Rice Best Pick, Prediction and Odds
Vanderbilt at Georgia Best Pick, Prediction and Odds
Virginia at Florida State Best Pick, Prediction and Odds
Washington at USC Best Pick, Prediction and Odds
West Virginia at Iowa State Best Pick, Prediction and Odds
Western Michigan at Buffalo Best Pick, Prediction and Odds
Wyoming at North Dakota State Best Pick, Prediction and Odds

Listed from the live site on 25 September 2026. Lines move through the week; each prediction states when its prices were read.