Week 4 of the 2025 college football season is still months away, but it’s never too early to bet on the action. We’ve only got early odds for a handful of games, but keep an eye on your favorite sports betting sites over the next few months as they update their odds accordingly as kickoff approaches.

Even this early, the board is packed with high-value matchups across the Big Ten, SEC, and more. If you missed our Week 3 breakdown, be sure to take a gander. We’re still quite a ways away from the College Football Playoffs picture beginning to take shape or the CFP Championship odds coming into focus, but we can get an early look at what Week 4 has to offer.

College Football Week 4 Schedule

College Football Week 4 Odds

Keep an eye on the latest College Football odds and monitor how the lines change throughout the week.

Oregon enters Week 4 as the biggest favorite on the board, laying -27.5 against Oregon State. Washington is also a double-digit favorite in a heated in-state rivalry. And don’t forget to follow our best handicappers for more top-rated college football picks.

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College Football Week 4 Predictions

Let’s take a look at the featured College Football Week 4 games and make our NCAAF Picks for each matchup.

Illinois Fighting Illini vs. Indiana Hoosiers Odds

Indiana is coming off a historic 2024 season, one that culminated in a College Football Playoff appearance and an 11-1 record against Power Two competition. Curt Cignetti’s arrival sparked immediate success, with his up-tempo scheme turning Indiana into a legitimate football school seemingly overnight. The Hoosiers didn’t just win, they were dominant. Their only two losses came against the teams that played for the national title, Ohio State and Notre Dame. Not too shabby.

With the majority of their top contributors returning and another strong crop of transfers coming in, Indiana enters 2025 with actual momentum and a newfound reputation to uphold.

Illinois is also on the rise. After a 10-win season and a Citrus Bowl victory, the Illini enter 2025 as a consensus top-15 team in preseason polls. They return 16 starters, including quarterback Luke Altmyer and a host of NFL-caliber talent like linebacker Gabe Jacas and tackle JC Davis. The program reloaded at wide receiver, adding Hudson Clement from West Virginia and looking for a breakout year from 4-star recruit Malik Elzy. With a favorable Big Ten schedule and serious defensive depth, Illinois has a real shot to contend again, though their toughest tests – including this very road date at Indiana – will define the season.

Illinois Fighting Illini vs. Indiana Hoosiers

Both of these teams had fantastic seasons last year. Both are primed for success this season as well. Unfortunately, one will have to lose this game and drop down a peg or two in the conference.

Oddsmakers have Indiana favored by 2.5 points at home, and that number feels spot on. Both teams bring back a ton of talent, but Indiana’s ceiling looks just a little higher, especially at home in a revenge-tinged Big Ten opener. Illinois has the trenches to make this close, but with Cignetti’s proven system and a rocking Memorial Stadium crowd, we’ll lay the points.

Bet: Indiana Hoosiers -2.5 (-110)

Florida Gators vs. Miami Hurricanes Odds

This might be the best Florida team in years, but whether that’s enough to make noise in the always-stacked SEC is the question.

After enduring one of the roughest four-year stretches in program history, Napier seems to finally have the depth and talent to stabilize things in Gainesville. The offensive line is solid, the defense improved dramatically at the end of last season, and quarterback DJ Lagway is a star in the making. Still, Napier is 0-10 against ranked teams, and the Gators’ biggest weakness has been beating quality opponents in recent years. They’ll get an early test when they head south to take on Miami, a team that trounced them in Gainesville, 41-17, to open 2024.

On the other side, Miami looks like a legitimate ACC contender with real playoff aspirations. There’s no Clemson or Georgia Tech on the 2025 slate, and the Hurricanes are loaded. Georgia transfer Carson Beck should stabilize what has been a fraught QB position and raise the team’s ceiling.

Florida Gators vs. Miami Hurricanes Predictions

Miami’s defense was already tough. While the loss of linebacker Francisco Mauigoa hurts, the unit still returns plenty of production. The penalties that plagued the Canes in 2024 will need to be cleaned up, but the team’s 2025 win total is set at 8.5 for good reason. This is one of the most stacked Miami teams we’ve seen since the turn of the century, which is saying something.

With the game in Miami and Florida’s consistent struggles against high-end competition over the years, the Canes should have the edge. Expect the Gators to keep it close for a while, but Beck’s experience and Miami’s defensive depth should prove too much down the stretch.

Bet: Miami Hurricanes -4.5 (-110)

Oregon State Beavers vs. Oregon Ducks Odds

Oregon enters the 2025 season with serious momentum, riding a 13-1 campaign and returning much of the core that made Dan Lanning’s squad a playoff contender. The Ducks are deep, physical, and disciplined, and they don’t drop regular-season games to teams they’re supposed to beat.

Their only close calls in 2024 came against ranked foes and Boise State; otherwise, they were coasting. The Ducks are going to have a new QB under center following the departure of Dillon Gabriel, but they’ll be in good hands if Dante Moore wins the job, as expected. With three home games on deck against Montana State, Oklahoma State, and Oregon State, the Ducks are expected to be multiple-touchdown favorites in each, and the Beavers don’t pose much of a threat on paper.

Oregon State’s offense enters 2025 with some promise but a lot of unknowns. The Beavers were wildly inconsistent late last season, scoring under 20 points in four of their final five games. While RB Anthony Hankerson is a reliable workhorse (1,000+ yards, 15 TDs), the passing game struggled. Maalik Murphy, the Texas transfer via Duke, takes over at QB and brings some upside, but his weapons are largely unproven outside of Trent Walker.

The O-line lost star guard Joshua Gray and must break in multiple new starters. On defense, things are rougher. The Beavers were dead last in FBS with just seven sacks in 2024. There are some intriguing pieces – Tevita Pome’e up front, USC transfer Raesjon Davis at linebacker, and veteran safety Skyler Thomas – but it’s a patchwork group with major holes, especially at corner.

Oregon State vs. Oregon Predictions

This is a rivalry in name only right now. Oregon is bigger, faster, more experienced, and playing at home. Oregon State has potential in spots, but their defensive front is no match for the Ducks’ offensive line, and asking Murphy to keep pace in his first big test is a lot. Lanning doesn’t let his team play down to the opponent, and this one could get ugly early.

The Ducks should be in contention for another Big Ten title, while the Beavers will be lucky to finish above .500 on the season. Look for Oregon to run away with this game.

Bet: Oregon Ducks -27.5 (-110)

Texas Tech Red Raiders vs. Utah Utes Odds

The Red Raiders have embraced the portal era better than most, overhauling their defense after a rough 2024 campaign. They added high-upside linemen like Howard Sampson and Will Jados to form what might be the Big 12’s best defensive front. The offense looks solid, with USC transfer Quinten Joyner filling in at running back and a veteran O-line that added NFL-caliber depth in Hunter Zambrano. Joey McGuire’s team is physical, aggressive, and deep, which are traits that could make them a dark-horse CFP contender if the new defensive pieces gel.

Utah is banking on dual-threat QB Devon Dampier and an improved offensive line to engineer a bounce-back year. Dampier has shown he can be dynamic with his arm and legs, and he’s supported by Washington State transfer Wayshawn Parker and another all-purpose weapon, Nate Johnson. On defense, Utah still has its soul: a rugged, veteran linebacker group and emerging stars like Logan Fano and Smith Snowden. That’s an 80-grade name right there, folks. The unit lacks some depth at corner and tackle, but it’s a proven system and should hold up at home.

Texas Tech Red Raiders vs. Utah Utes Predictions

This line is tight for a reason. Utah has a more established identity and the underrated advantage of playing home games at altitude, but Texas Tech is the more talented team top-to-bottom if the new pieces hit. Utah’s edge at QB and home field advantage gives them a shot, but this may come down to who controls the line of scrimmage, and Texas Tech might just have the best unit on the field. Why not mix an upset pick into things?

Bet: Texas Tech Red Raiders +3.5 (-110)

Michigan Wolverines vs. Nebraska Cornhuskers Odds

Michigan enters 2025 with big expectations and an equally large question mark in freshman QB Bryce Underwood. Underwood famously abandoned his commitment to LSU after Michigan came in at the last-minute with a whopping $10 million offer to shift his allegiance to Ann Arbor. Underwood was the top-ranked quarterback in the 2025 class, and he’s expected to start for the Wolverines right away.

The Wolverines’ toughest road tests include Oklahoma, Nebraska, and USC, and Underwood’s early performances may potentially define the season. Michigan’s floor appears to be solid given its overall talent, but its ceiling hinges on how fast the young pieces mature and whether they can win away from Ann Arbor.

Nebraska finally seems to be coming around after a few decades of failing to meet expectations. A revamped roster filled with raw talent nearly collapsed late last season, but this year’s schedule breaks favorably. No Ohio State. No Oregon. And their toughest games – Michigan, Iowa, USC – are all at home.

Dylan Raiola’s development is the swing factor in Nebraska’s quest to break through in 2025. He’s got the arm talent and leadership tools to elevate the program, but consistency will be the difference. As a freshman, the Patrick Mahomes wannabe flashed everything from touch throws to timely scrambles, even engineering a signature win over Wisconsin and holding his own against Ohio State.

But his true ceiling will be measured by whether he can avoid the up-and-down stretches that plagued his first year. If he grows into a steady, high-level playmaker in Dana Holgorsen’s offense, Nebraska has the supporting cast – and the schedule – to make serious noise in the Big Ten. If not, they risk another season of “almosts.”

Michigan Wolverines vs. Nebraska Cornhuskers Predictions

This is the kind of road spot Michigan hasn’t always handled well. Nebraska’s home-field setup and favorable schedule timing put them in a great position to steal this one outright, especially if Underwood looks like a freshman in a hostile Big Ten environment.

Take the points and the Cornhuskers to pick up a huge conference victory, which could set them up to be a contender in the Big Ten this year.

Bet: Nebraska Cornhuskers +3 (-110)

Washington Huskies vs. Washington State Cougars Odds

Washington heads to Pullman laying 11.5 points, and this year’s Apple Cup features two programs at very different stages of their rebuild.

Under Jedd Fisch, the Huskies are looking to quickly regroup from last season’s 5–7 stumble that followed a shocking run to the National Championship Game. Despite losing most of their top-end NFL talent, Washington was way more competitive than their record suggested. Five of their seven losses came by one score, and they were a missed two-point conversion from a bowl bid. With Fisch importing some of his core Arizona players and quarterback Demond Williams Jr. looking like a potential star, the Huskies have a clear plan and reason for optimism.

Washington State is more of a blank slate. With a new staff, major portal turnover, and a quarterback battle still unresolved heading into the fall, the Cougars are in full reset mode. Zevi Eckhaus is the likely starter, and while he impressed late in 2024, the supporting cast around him isn’t what it was. The offensive line is unproven, and the defense – largely rebuilt through FCS and G5 transfers -faces a steep learning curve against a power-conference schedule. The spring and summer will be important for building cohesion, but Week 1 could come too soon for everything to click.

Washington Huskies vs. Washington State Cougars Predictions

This game feels like a mismatch on paper. Washington returns more talent, has more continuity at quarterback, and has a better overall infrastructure. Unless the Cougs drastically outperform expectations early in the year, it’s tough to see them keeping up offensively. The Huskies have the more explosive offense and a defense that should feast on an unsettled Wazzu line.

Bet: Washington Huskies -11.5 (-110)

Best College Football Week 4 Bets

Here are our favorite wagers from this week’s board:

• Indiana -2.5 (-110)
• Miami -4.5 (-110)
• Oregon -27.5 (-110)
• Texas Tech +3.5 (-110)
• Nebraska +3 (-110)
• Washington -11.5 (-110)

If you parlay all six of our games at -110 odds, a $100 bet returns approximately $5,377. Now that’s some serious coin, folks.