Kansas City Royals vs Chicago White Sox Picks and Predictions May 7th 2025

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The Kansas City Royals are in red-hot form, having won eight straight games and 16 of their last 17 against the Chicago White Sox. With four consecutive wins under their belt and aiming for their 10th straight home victory over the White Sox, the Royals have been dominating this American League matchup.

Wacha’s Winning Ways vs. Chicago

Veteran pitcher Michael Wacha (1-4, 3.52 ERA) has been a model of consistency, but unfortunately, he’s received minimal offensive backing from his team this season. In his seven starts, Kansas City has scored only seven total runs while he’s on the mound, leading to a 3-4 team record in those appearances.

Despite this lack of support, Wacha has excelled historically against the White Sox, posting a 5-1 record and a 1.06 ERA in five starts since 2023. His dominance offers Kansas City a strong advantage heading into Wednesday night’s game. Check This Week’s Baseball Picks from MLB Expert Handicappers

Run Support Issues Persist

The Royals’ lineup cooled down after a power-hitting performance over the weekend in Baltimore. In their recent games, they’ve scraped by with narrow victories, including a 4-3 comeback win on Tuesday aided by a defensive miscue from Chicago’s Chase Meidroth. Still, the team remains focused.

“The whole idea is to pass the baton. Anything we can do to get guys in scoring position,” said outfielder Kyle Isbel, who homered in Tuesday’s win.

Key Performers to Watch

PlayerRecent HighlightsImportance
Michael Wacha (KC)1.06 ERA vs CHW since 2023Crucial veteran presence
Bobby Witt Jr. (KC)Walk-off RBI single on TuesdayOffensive catalyst
Kyle Isbel (KC)6-for-18 with 2 HR in last 7 gamesPower and clutch hitting
Andrew Vaughn (CHW)6-for-16, 2 HR vs WachaThreat to watch
Jonathan Cannon (CHW)3.00 ERA vs KC in 2023Quietly effective

White Sox Reeling from Mistakes and Misfortune

With an AL-low 10 wins, the Chicago White Sox are grappling with inconsistency and missed opportunities. On Tuesday, Meidroth’s dropped pop-up in the ninth inning led to Kansas City’s winning rally.

“Don’t dwell on it too long, and get back playing,” said Meidroth.

They’ll send Jonathan Cannon (2-3, 4.26 ERA) to the mound. Despite his team losing all three starts against Kansas City last year, Cannon pitched effectively, allowing only six total earned runs across 18 innings.

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Matchup Analysis: Royals vs. White Sox

Pitching Comparison

PitcherERARecordWHIP2023 vs Opponent
Michael Wacha (KC)3.521-41.161.06 ERA vs CHW
Jonathan Cannon (CHW)4.262-31.333.00 ERA vs KC

Team Trends

  • Royals: 8-game winning streak, 9 straight home wins vs CHW
  • White Sox: Lost 16 of last 17 vs KC, error-prone defense

Why This Game Matters

For the Royals, maintaining their streak and giving Wacha overdue run support is crucial. For the White Sox, avoiding yet another loss to a division rival is essential to avoid further spiraling.

This AL Central battle is more than just another mid-week game—it’s a momentum decider for both teams.


Final Thoughts

The Kansas City Royals have the upper hand going into Wednesday night, but the key will be delivering timely offense to support Michael Wacha’s solid pitching. The White Sox, meanwhile, need a clean, focused performance to stand a chance of snapping their skid.

By Taylor Smith | April 8, 2025
By Taylor Smith | April 1, 2025
By Taylor Smith | March 29, 2025
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Mike Williams
Mike Williams | Handicapper

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Mike uses his strong sports knowledge to analyze all the angles to find the most profitable wagers. Iron Mike handicaps MLB, college football, NFL, NBA, and NCAA basketball. I'm an actual sports and gambling junkie!

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