New York Mets vs Minnesota Twins Picks and Predictions April 21st 2026

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The Twins open this interleague set at Citi Field on Tuesday night with an 11-11 record and a four-game losing streak after getting swept at home by Cincinnati. The Mets are in even worse shape at 7-15, last in the NL East, and have dropped 11 straight, their longest skid since 2004. First pitch is set for 7:10 p.m. ET, and the listed TV coverage is Twins.TV Presented by Progressive and SNY.

One important update from your original setup: Minnesota is not sending Mick Abel. He went on the 15-day injured list Monday with right elbow inflammation, so Simeon Woods Richardson gets the start opposite Nolan McLean. The weather should stay fairly quiet, with temperatures in the upper 40s, light wind, and partly cloudy skies around first pitch.

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Minnesota Twins vs New York Mets Odds

These are the current betting lines, and bettors should always monitor the latest MLB odds before first pitch because this market has been moving off the pitching change.

TeamMoneylineRun LineTotal
Minnesota Twins+150+1.5 (-146)O 7.5 (-105)
New York Mets-184-1.5 (+121)U 7.5 (-115)

Minnesota Twins Betting Form

Minnesota is coming in off a rough weekend, but the bigger picture is still better than the current streak suggests. The Twins are 11-11, third in the AL Central, with a top-10 home run total and one of the better walk rates in the league. Through 22 games they are batting .230 with a .332 OBP, 26 home runs, and 98 walks, which gives them a much stronger offensive base than the Mets despite the recent slide. That is why they still show up as a live dog on the daily MLB picks board.

The injury picture is not ideal, but it is not catastrophic either. Pablo López is out for the year after elbow surgery, David Festa remains on the 60-day IL, and Cody Laweryson is still sidelined, but Royce Lewis is tracking toward activation and Matt Wallner is day-to-day. The bigger short-term issue is Abel going down right before this start, because it pushes Minnesota to Woods Richardson instead of the hotter arm.

Woods Richardson is the weak spot in the handicap. He enters 0-3 with a 6.10 ERA and 1.60 WHIP, and he was hit hard in his last outing when Boston tagged him for six earned runs in five innings. He has not missed many bats either, with just 11 strikeouts over 20 2/3 innings. That makes it hard to trust Minnesota early, and it is the main reason the Twins are plus money here instead of shorter.

New York Mets Betting Form

The Mets are a mess right now, and there is not much point pretending otherwise. They have lost 11 straight, were outscored 62-19 during that skid, and are batting .200 over those 11 games. Even Sunday’s 2-1 extra-inning loss to the Cubs fit the same script: decent enough pitching, almost no offense, and another game that slipped away late. That broader form is why New York has been falling down the MLB previews board.

The lineup is still missing help. Juan Soto remains on the 10-day IL with a right calf strain, Jorge Polanco just hit the injured list, and several bullpen arms are still out, including Reed Garrett, Dedniel Núñez, and Tylor Megill. Soto is expected back during this homestand, but as of this game he is still not in the mix.

McLean is the reason the Mets are favored, and that part makes sense. He comes in 1-1 with a 2.28 ERA, a 0.76 WHIP, and 28 strikeouts in 23 2/3 innings. He was excellent in his last outing too, allowing one run over seven innings against the Dodgers. If New York wins this game, it probably starts with McLean controlling the first six or seven innings and keeping Minnesota from cashing in its walk-heavy profile.

Minnesota Twins vs New York Mets Matchup Breakdown

This game really comes down to a tug-of-war between the better lineup and the better starter. Minnesota has been the more productive offense overall, with more power and a much better on-base profile, while New York is dragging an offense that has barely scored during this losing streak. But the starter edge is not small. McLean has clearly outpitched Woods Richardson, and that gap is large enough to justify the Mets being favored. The question is whether it justifies this price. That is where the MLB betting guide mindset matters, because this is more of a number game than a pure pick-the-winner game.

I do not think New York should be laying this kind of number with the offense in its current state. The Mets have scored 19 total runs during the 11-game skid, and Minnesota at least has a cleaner path to a quick swing if McLean finally has an off night. On the other side, Woods Richardson has been volatile enough that the full-game total is tricky. A 7.5 under makes sense on paper because the Mets cannot hit, but one bad inning from the Twins starter could blow it up. That leaves the dog price as the more appealing angle than forcing the total.

Minnesota Twins vs New York Mets Predictions and Best Bets

My lean is Minnesota on the moneyline, and it is almost entirely about price. McLean is the best pitcher in this game, so I understand why New York is favored. But the Mets have given bettors no reason to lay nearly -180 with this offense, especially with Soto still out and the team not even reaching average run production during the skid. Minnesota has enough patience and enough pop to steal this if McLean is merely good instead of dominant.

I would leave the total alone unless you strongly trust McLean to carry the night. Under 7.5 is defensible because of the weather and the Mets’ offensive collapse, but Woods Richardson has been too shaky for me to make that the main play. The better betting angle is taking the plus money and trusting that New York has not earned this favorite price yet.

Best Bet: Twins Moneyline +150.

MLB Picks and Handicappers on ScoresAndStats

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Knup Sports – POTD
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Top Winners – This Week
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