Toronto Blue Jays vs Pittsburgh Pirates Picks and Predictions May 22nd 2026

Toronto Blue Jays vs Pittsburgh Pirates Fri, May 22, 00:00 am.
Toronto Blue Jays
ML: -164
0
0
Pittsburgh Pirates
ML: +139
Last Updated on

The Pittsburgh Pirates visit the Toronto Blue Jays on Friday night at Rogers Centre for the opener of a three-game interleague series. First pitch is scheduled for 7:07 PM ET, with coverage listed on SN1 and SportsNet Pittsburgh. Pittsburgh enters at 26-24 and fifth in the NL Central, while Toronto comes in at 23-27 and third in the AL East.

Both teams are coming in with a little momentum. The Pirates have won two straight after taking the final two games of their road series against St. Louis, and the Blue Jays also won two in a row after closing their Yankees series with a 2-0 shutout. That gives this game a better feel than the records might suggest.

This matchup fits into the daily MLB previews board because the side is not only about form. It is about whether Kevin Gausman can control a Pittsburgh lineup that has been better than expected, and whether Bubba Chandler can finally limit walks long enough to give the Pirates a real road underdog shot.

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Pittsburgh Pirates vs Toronto Blue Jays Odds

These are the current betting lines for Pittsburgh Pirates vs Toronto Blue Jays, and bettors should always monitor the latest MLB odds before locking anything in because Toronto’s favorite price can move quickly with lineup news.

TeamMoneylineRun LineTotal
Pittsburgh Pirates+137+1.5 (-160)O 8 (-110)
Toronto Blue Jays-164-1.5 (+132)U 8 (-111)

Pittsburgh Pirates Betting Form

Pittsburgh needed a response, and it got one in St. Louis. The Pirates had lost four straight before taking back-to-back games from the Cardinals, including a 6-2 win on Thursday behind seven strong innings from Braxton Ashcraft. That matters because this team had started to feel a little flat, then suddenly the energy came back.

The lineup is not empty. Pittsburgh ranks well in batting average and on-base percentage, and Brandon Lowe just gave them a strong game with a homer and a walk. Henry Davis also went deep, and the Pirates have enough contact to make Gausman work if they stay patient. The key is not chasing early. Bettors looking through daily MLB picks will probably see Pittsburgh as a live underdog, but only if Chandler avoids giving Toronto free baserunners.

Chandler is the swing piece. He is 1-5 with a 5.14 ERA and a 1.50 WHIP, and the walk issues have been the biggest problem. He has lost four straight decisions and allowed too much traffic during that stretch. The stuff is better than the results, but that only matters if he throws enough strikes. Against a Toronto lineup that can grind at-bats, Chandler has to get ahead early or this could turn into a short start.

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Toronto Blue Jays Betting Form

Toronto has been trying to find traction for most of the season, and the last two games in New York helped. The Blue Jays beat the Yankees 2-0 on Thursday with five pitchers combining to hold New York to three hits. That type of win can settle a team down, especially heading back home for a six-game stand.

The offense is still not fully healthy. Anthony Santander, Alejandro Kirk, Nathan Lukes, and Addison Barger are all out, which cuts into depth. But Vladimir Guerrero Jr. is still the main bat in the middle, George Springer just homered in New York, and Ernie Clement has been one of the steadier contact pieces. Toronto does not need to explode here. It needs traffic against Chandler and a couple timely swings.

Gausman gives the Blue Jays the clearer starting point. He is 3-3 with a 3.45 ERA, 53 strikeouts, and a 1.05 WHIP. That WHIP is important because Pittsburgh’s lineup has done a good job getting on base this season. If Gausman limits walks and keeps the split working down, Toronto should control the first half. His career numbers against Pittsburgh are not great, but his current profile is still much cleaner than Chandler’s.

Pittsburgh Pirates vs Toronto Blue Jays Matchup Breakdown

The starting pitcher edge leans Toronto. Gausman has the better command, better WHIP, and more reliable strikeout profile. Chandler has upside, but right now he is too walk-prone to trust against a lineup that can be patient enough to push his pitch count.

The Pirates have the better recent offensive feel after the St. Louis series, and their on-base profile gives them a path. If Brandon Lowe, Henry Davis, and the top of the order can extend at-bats, they can get into Toronto’s bullpen earlier than the Blue Jays want. Pittsburgh’s road record is also respectable enough that the plus-money case is not ridiculous.

The Blue Jays’ bullpen is coming off a heavy but excellent game against the Yankees, so that is one small thing to watch. Toronto used five arms Thursday, and while the performance was great, another tight game could test the middle relief group. Pittsburgh’s best chance may come if Chandler survives five innings and the Pirates can force leverage spots late.

From a betting perspective, this is a useful MLB betting guide type of game because the favorite makes sense, but the number is not cheap. Toronto has the better starter and home field. Pittsburgh has better record form and enough offense to make this uncomfortable if Chandler is simply average.

Pittsburgh Pirates vs Toronto Blue Jays Predictions and Best Bets

I lean Blue Jays on the moneyline. Gausman is the biggest reason. He gives Toronto the more stable pitching profile, and Chandler’s walk issues are tough to ignore. In a road underdog spot, Pittsburgh needs clean innings from its starter, and Chandler has not consistently provided that.

The Pirates are not a bad underdog, though. Their offense has been better than expected, and the last two games in St. Louis probably helped reset the clubhouse a bit. If Chandler finds the zone and Pittsburgh keeps getting traffic, this can absolutely be a one-run game. That is why I would not be in a hurry to lay Toronto -1.5.

The total leans over 8. Chandler’s WHIP creates scoring chances, Toronto’s bullpen had to cover a lot Thursday, and Pittsburgh’s lineup is getting on base well enough to contribute. Gausman can slow this down, but the model score around 5-4 makes sense. The over is not just a Blue Jays offensive bet. It also counts on Pittsburgh doing enough to push the game past a fair number.

For bettors comparing this matchup with other premium MLB picks, I would put Toronto moneyline and Over 8 in the same conversation. The Blue Jays are the cleaner side, but the over has a better chance to cash even if Pittsburgh makes it tight.

Best Bet: Blue Jays Moneyline -164.

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MLB Picks and Handicappers on ScoresAndStats

Pirates vs Blue Jays is the kind of MLB matchup where the favorite is understandable, but the card still needs price discipline. Toronto has the starter edge, Pittsburgh has the better record, and the total sits right in a range where walks and bullpen usage matter. That is where following top sports handicappers can help bettors compare moneyline, run line, total, and first five innings angles.

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